Protein Alignment Syt1 and TC2N

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_689545.2
• Gene: TC2N / 123036
• HGNCID: 19859
• Length: 490
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 79/339 - (23%)
• Similarity: 138/339 - (40%)
• Gaps: 47/339 - (13%)

  Fly   135 RRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFK 199
            :||:::..:          :.||....|:.|.. |.....|......|||.|      .||||.|
Human   183 QRFIQRHDS----------LSSVPSSSSSRKNS-QGSNRSLDTITLSGDERD------FGRLNVK 230

  Fly   200 LEYDFNSNSLAVTVIQAEEL--PALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFT 262
            |.|:.:...:.:||:|..:|  |: ..|.|....:|..|...|...|::.....:.:..|.|||.
Human   231 LFYNSSVEQIWITVLQCRDLSWPS-SYGDTPTVSIKGILTLPKPVHFKSSAKEGSNAIEFMETFV 294

  Fly   263 FKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDL-----VSV---EG 319
            | ::...:.....|||.|  ..:..:...|||..:.|.|:. .|.::...|:     :||   |.
Human   295 F-AIKLQNLQTVRLVFKI--QTQTPRKKTIGECSMSLRTLS-TQEMDYSLDITPPSKISVCHAEL 355

  Fly   320 EGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIK 384
            |.|      .||.    ....::.:.||||:.|...........:||:.:..:|:.:.||||.:.
Human   356 ELG------TCFQ----AVNSRIQLQILEARYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLL 410

  Fly   385 KCTLNPY-YNESFSFEVPFEQIQK-ICLVVTVVDYDRIGTSEPIGRCILGCMGTGTE-LRHWSDM 446
            |.:.... :.|:..|  |..|.:| |..::.:.....:.....:|:..:.......| :..|.:.
Human   411 KASNGRVKWGETMIF--PLIQSEKEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEAVNQWKET 473

  Fly   447 LASPRRPIAQWHTL 460
            :.:|.:.:.:||.|
Human   474 VINPEKVVIRWHKL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	4/25 (16%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	34/130 (26%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	28/138 (20%)
TC2N	NP_689545.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..215		6/36 (17%)
		C2A_Tac2-N	240..342	CDD:176066	26/106 (25%)
		C2B_Tac2-N	353..487	CDD:176074	30/145 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	447..449		0/1 (0%)