Protein Alignment aph-1 and APH1A

DIOPT Version :10

• Sequence 1: NP_608710.1
• Gene: aph-1 / 33467
• FlyBaseID: FBgn0031458
• Length: 238
• Species: Drosophila melanogaster
• Sequence 2: NP_001071096.1
• Gene: APH1A / 51107
• HGNCID: 29509
• Length: 265
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 114/243 - (46%)
• Similarity: 163/243 - (67%)
• Gaps: 12/243 - (4%)

  Fly     6 FFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISS-LWYALIPLKE--------- 60
            ||||||:||||.||||:.|:|.||:|:|||:|.|||||:|||::| :|:.|:.:.:
Human     6 FFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYG 70

  Fly    61 FLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISGMFALV 125
            .|.||...||..||.||:..|::|:..::||.:::||.|...:...:||||||.||||||:|:::
Human    71 LLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVI 135

  Fly   126 NVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVFSHLFV 190
            |:|||..|||.:|:.|.:..:|:|||....:||||||||.|:||:|.:...|..:|.||.|||..
Human   136 NILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLT 200

  Fly   191 SLITLLNANELYTTTLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            |.:|.|  |..|..:||..|.||:..|:.||..|||:.||.::.:.|:
Human   201 SGLTFL--NPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCR 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_608710.1	Aph-1	3..225	CDD:461830	108/228 (47%)
APH1A	NP_001071096.1	Aph-1	3..233	CDD:461830	108/228 (47%)