DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment: Unc-89 and IKS1

Sequence 1:NP_001097440.1 Gene:Unc-89 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_012478.3 Gene:IKS1 SGDID:S000003593 Length:667 Species:Saccharomyces cerevisiae

Alignment Length:466 Identity:92/467 (20%)
Similarity:147/467 (31%) Gaps:172/467 (37%)


  Fly  3088 AKLVGIPLPE-VHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSIST 3151
            |.|..:..|. :|.:|.          .|:||........|:..||....|:   .|..||..|.
Yeast    51 ASLSALDFPSGIHQYKS----------PIASYVCPQCGTEINPDIINRRQLH---RRASAGVESE 102

  Fly  3152 SVTVHIEEN-------------EDQYIYKTYGRHPYV------RSKQLRY-QDKYDIGDE----- 3191
            |..:.|.||             ..:|.......|.:.      .:||.:: ::||.|.|:     
Yeast   103 SSRLSIPENTVPLGFEFANSSFSRRYFQSLERNHRHYALQNDSNNKQGQFSKNKYFIPDDLFIPG 167

  Fly  3192 -----------LGRGTQGITYHAVERSSGDNYAAKIMYGRPELRPFML------NELEMMN---- 3235
                       ||.|.:|..|..|.           ..|..||..|.|      |::|..|    
Yeast   168 YFRKFFKILSLLGNGARGSVYKVVH-----------TIGNTELGVFALKKIPIGNDMEWFNKCIR 221

  Fly  3236 ----------------TFNH--------KNLIRPYDAYDTDRS-----VTLIMELAAGGELVRDN 3271
                            |:||        ...:|..|...:|..     :.::.:..:||.| .|.
Yeast   222 EVKALSSLTHKSANLITYNHVWLEMDSSVGFVRSIDGSQSDSQEEVPCIFILQQYCSGGNL-EDC 285

  Fly  3272 LLRRDY------------------------------YTERDIAHYIRQTLWGLEHMHEMGVGHMG 3306
            :||:.:                              .:...:...||....||..:|.:|:.|..
Yeast   286 ILRKVFNRFSDTESPEERKKKFRTRKKNHGKSGEVGLSTEQLVSIIRDIARGLHELHSIGLIHRD 350

  Fly  3307 LTIKD-LLISVVGGD------------------IIKVSDFGLSRKINRHNLSTLDYGMPEFVSPE 3352
            |...: ||::....|                  .|.:.|.|.|:......|.|...|..||.:|:
Yeast   351 LKPSNCLLLTPFKSDNENDNVYDREHNSDEFFPSIVIGDLGESQLEGESRLGTGCTGTLEFTAPD 415

  Fly  3353 VV-----------------NKEGVNFSHDMWTVGLITYVLLGGHNPF---LGIDDRETLTKIREG 3397
            ::                 ......|:.||:::|:|.|.::.|..||   |.|.|.:  .:|:..
Yeast   416 LIIQGRPVSSSTLPSRSSHTYNEYTFASDMYSLGMICYFIVFGELPFEPQLDIVDLK--VRIKNF 478

  Fly  3398 RWDFKDEIWTH 3408
            |:|.:..|..|
Yeast   479 RFDTEGMIEKH 489

Known Domains:


GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254 17/70 (24%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 68/353 (19%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
IKS1NP_012478.3 S_TKc 173..522 CDD:214567 64/332 (19%)
PKc 179..526 CDD:270622 64/326 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.