DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and CMK1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_116669.1	Gene:	CMK1 / 850568	SGDID:	S000001910	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	279	Identity:	75/279 - (26%)
Similarity:	138/279 - (49%)	Gaps:	10/279 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  3170 GRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMY-----GRPELRPFMLN 3229
            |:..:|:......:.||..|..||.||.|:...|....:|::.|.||:.     |.......:.:
Yeast    21 GKMAHVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYD 85

  Fly  3230 ELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGL 3294
            ||:::...:|.|::...|.:::.....:|.:||.||||. |.:|::..:||.|....:.:.|..:
Yeast    86 ELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELF-DRILKKGKFTEEDAVRILVEILSAV 149

  Fly  3295 EHMHEMGVGHMGLTIKDLL-ISVVGGDIIKVSDFGLSRKI-NRHNLSTLDYGMPEFVSPEVVNKE 3357
            ::||...:.|..|..::|| |.......:.|:|||::::: :...|.....|...:|:|||:.::
Yeast   150 KYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQD 214

  Fly  3358 GVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRW--DFKDEIWTHISDDGRDFISRL 3420
            |.....|:|::|:|||.||.|::.|.....::.|.:...|.:  .|....|..:|:..:.||.:.
Yeast   215 GHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKA 279

  Fly  3421 LLYSPEERMDVKTALKHPW 3439
            |...|.:|......|:.||
Yeast   280 LNLDPSKRPTAAELLEDPW 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011	73/267 (27%)
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	71/262 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900