Protein Alignment Vmat and Slc18b1

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001395141.1
• Gene: Slc18b1 / 76306
• MGIID: 1923556
• Length: 475
• Species: Mus musculus
• Alignment Length: 368
• Identity: 100/368 - (27%)
• Similarity: 164/368 - (44%)
• Gaps: 52/368 - (14%)

  Fly   239 VGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLS---TIIFAF------GRSYLVL- 293
            :|::|...|..:||.:.:.|.....||......||   ||:|   ||:|..      |..::.:
Mouse    90 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAG---MFVSGGVTILFGVLDQLPEGPIFIAMC 151

  Fly   294 FVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGL----ALGVLIGPPFGGVMYEFV 354
            |:.|.:..||...:..:...:||..|.      |.:...:|.|    .||::.|||.||::|:..
Mouse   152 FLVRIVDAIGFGAAITASSSILAKAFP------NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSF 210

  Fly   355 GKSAPFLILAALALGDGLLQLFMLQPSIQKAETEP--PSLKSLISDPYILIAAGAITFANMGIAM 417
            |...||:.|..:.|....|.|::| ||.   |::|  .|...|::.|.:.:.|..|...:.....
Mouse   211 GYEVPFIFLGCIVLLMIPLNLYIL-PSY---ESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGF 271

  Fly   418 LEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHK---IGRWFAACLGLIIIGGCL 479
            |:|:|.|::::....:....|:.||..|:||.|.:.|||.|..|   :.:|... .|.:|..||.
Mouse   272 LDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLV-FGNLITAGCY 335

  Fly   480 IF---IPM---ATSITHLIIPNAGLGFAIGMVDSSMMPEL---GYLVDIRHS-AVYGSVYALGDV 534
            :.   :|:   .:.:..|::.....|.:.||......||:   .|......| :..|.|..|...
Mouse   336 MLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGA 400

  Fly   535 AFCVGFAVGPALSGSLVKSIGFEW---------MLFGIAILCF 568
            .:.||..:||.|.|.|.:.|||||         :|.|:::..|
Mouse   401 MWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALF 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	100/368 (27%)
Slc18b1	NP_001395141.1	MFS_SLC18B1	55..444	CDD:340943	100/368 (27%)