Protein Alignment Vmat and slc18a2

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_031762366.1
• Gene: slc18a2 / 101732756
• XenbaseID: XB-GENE-940058
• Length: 515
• Species: Xenopus tropicalis
• Alignment Length: 497
• Identity: 279/497 - (56%)
• Similarity: 346/497 - (69%)
• Gaps: 68/497 - (13%)

  Fly   130 WMVSWRGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLY----------DIRHPD-APLDSF--- 180
            |:...|.|.:|:|:||.|||||||||||.||||||.:||          |..||. ||..|.
 Frog    11 WLREGRQSRKLILLIVFIALLLDNMLLTVVVPIIPSYLYTMTHEGNSSQDEAHPSTAPGGSHSIF 75

  Fly   181 -------------------PR---TPLTSNVPPPPT--PCPCNKDGSEAAPLEISTISPEENETY 221
                               ||   ||.:|..|.|||  |..|.:..|
 Frog    76 SYYDNTTVTITNSTRSTHQPRSAVTPTSSPSPSPPTAPPADCPRADS------------------ 122

  Fly   222 YRELEERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLSTIIFAF 286
                     .|:.|.|:|||||||||.||||.||.:||:|:||||.|||||||.|||:|||:|||
 Frog   123 ---------SLLNENVKVGLLFASKATVQLLTNPFIGPMTNRIGYQIPMFAGFCIMFVSTIMFAF 178

  Fly   287 GRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMY 351
            ..||.:||:||:|||||||||||:||||||..:|||:||||||||||||||:|||:|||||.::|
 Frog   179 SGSYALLFIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSILY 243

  Fly   352 EFVGKSAPFLILAALALGDGLLQLFMLQPS-IQ-KAETEPPSLKSLISDPYILIAAGAITFANMG 414
            |||||:||||:||.|.|.||.||||:|||| :| :::|..| |.:||.|||||||||:|.||||.
 Frog   244 EFVGKTAPFLVLAVLVLFDGALQLFVLQPSRVQPESQTGTP-LLTLIRDPYILIAAGSICFANMA 307

  Fly   415 IAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCL 479
            ||||||:||:||::.|.:.:|:.||||||||||||||||:||||.||:|||..|.:|:|::|..:
 Frog   308 IAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNVFGPLAHKMGRWLCAFIGMIVVGISI 372

  Fly   480 IFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGP 544
            |.:|.|.:|..||.|..|:|||||||||||||.:|||||:||.:|||||||:.|||||:|||.||
 Frog   373 ICVPFARNIYGLIAPTFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGFAFGP 437

  Fly   545 ALSGSLVKSIGFEWMLFGIAILCFMYAPLLTLLKNPPTSDEK 586
            :..|::.|||||.|::..|.::..::|||...|::||..:||
 Frog   438 SAGGAIAKSIGFPWLMTIIGVVDVLFAPLCLFLRSPPAREEK 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	270/476 (57%)
slc18a2	XP_031762366.1	MFS_SLC18A1_2_VAT1_2	22..471	CDD:340942	270/476 (57%)