DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axud1 and CSRNP2

DIOPT Version :9

Sequence 1:	NP_001259928.1	Gene:	Axud1 / 33419	FlyBaseID:	FBgn0261647	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_110436.1	Gene:	CSRNP2 / 81566	HGNCID:	16006	Length:	543	Species:	Homo sapiens

Alignment Length:	638	Identity:	189/638 - (29%)
Similarity:	260/638 - (40%)	Gaps:	191/638 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 SNLKRRLED--------------SESDAIDLVPDMSAP------PVAPQKRTK----RSINFDEV 309
            |.|||:.:|              |.||:.|....::.|      |.:..||.|    :::.||:|
Human     7 SGLKRKFDDVDVGSSVSNSDDEISSSDSADSCDSLNPPTTASFTPTSILKRQKQLRRKNVRFDQV 71

  Fly   310 KVFYFPRQQGFSCVPTAGGCTLGMGARHVGFKTMTLAEHAAELRRAHR-------------SQNQ 361
            .|:||.|:|||:.||:.||.:|||..||...::.||.|.|.|....||             ::..
Human    72 TVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKM 136

  Fly   362 ELQPRGSSSDDSEESEEDYLSEGSGSDAE-DGSN------GFLQPVTPKQRRALLKAAGVRKIDA 419
            :|...|:    .|..|.|.|:....||.: |..|      .||||:..|:|||||:|:||.:|||
Human   137 KLTKNGT----VESVEADGLTLDDVSDEDIDVENVEVDDYFFLQPLPTKRRRALLRASGVHRIDA 197

  Fly   420 SEKSECRDIRNSREVCGCSCREFCDPETCACSQAGIKCQVDRAMFPCGCTREACGNTVGRVEFNP 484
            .||.|.|.||.|||.|||.||.:||||.||||||||||||||..|||||:|:.|||..||:||||
Human   198 EEKQELRAIRLSREECGCDCRLYCDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNP 262

  Fly   485 TRVRTHYIHTVMRLDLEQRQGSVQGVQGGHLQPQQQQPSQQTIGYSPVGTAGSTSAYFLQTQSNY 549
            .||||||:||:|:|:||.::             |..:|:......||..:...|.|...:|| ::
Human   263 IRVRTHYLHTIMKLELESKR-------------QVSRPAAPDEEPSPTASCSLTGAQGSETQ-DF 313

  Fly   550 SSGYASPAYTPESSVSYYQQQVQQPGVPTAGQLIPQQQQAQSQSYAGYAQLDSLDSGLFASGSNA 614
            ....|.    .|::|.:.|         :|.:|  ::.:|:..|....|.|||
Human   314 QEFIAE----NETAVMHLQ---------SAEEL--ERLKAEEDSSGSSASLDS------------ 351

  Fly   615 TPSYGELYQSLSYGSTQITSYTAAYQQHSASPAVAVAPGAPSSCAYSSCAVPSVPPYGNATTTAS 679
                            .|.|......:...:....:.||..:.....:    .:|| |::....:
Human   352 ----------------SIESLGVCILEEPLAVPEELCPGLTAPILIQA----QLPP-GSSVLCFT 395

  Fly   680 SNVPYQTTAVSMTAASTSASPSRLVG----------NPVGSATASPATVSSSPATASGNEFISLS 734
            .|..:.|       |||..|||.|..          .||......|.|...|.:.....:....|
Human   396 ENSDHPT-------ASTVNSPSYLNSGPLVYYQVEQRPVLGVKGEPGTEEGSASFPKEKDLNVFS 453

  Fly   735 TPIASSSRLSQINDLLQHNRNTTAALVAVSEGLSGGRTSSSASTIDSIDTPPIVDDGQQRGCMSF 799
            .|:.|                    |||.|.      |..:|.....:...|           :.
Human   454 LPVTS--------------------LVACSS------TDPAALCKSEVGKTP-----------TL 481

  Fly   800 EALPPPLVNPAPIVAVVENKLPPMALPAPHAPPSAPQPRQPLEQHHPATSESS 852
            |||.|...||                         .:|..  |..||:.|.||
Human   482 EALLPEDCNP-------------------------EEPEN--EDFHPSWSPSS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axud1	NP_001259928.1	CSRNP_N	301..500	CDD:292638	110/222 (50%)
Axud1	NP_001259928.1	PHA03255	643..>786	CDD:165513	28/152 (18%)
CSRNP2	NP_110436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		10/43 (23%)
		CSRNP_N	63..278	CDD:318276	109/218 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..305		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..543		9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160221
Domainoid	1	1.000	218	1.000	Domainoid score	I2657
eggNOG	1	0.900	-	-		E1_KOG3813
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001585
OrthoInspector	1	1.000	-	-		otm40615
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13580
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3357
SonicParanoid	1	1.000	-	-		X1316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830