DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4271 and LPA

DIOPT Version :9

Sequence 1:	NP_608665.1	Gene:	CG4271 / 33410	FlyBaseID:	FBgn0031409	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_005568.2	Gene:	LPA / 4018	HGNCID:	6667	Length:	2040	Species:	Homo sapiens

Alignment Length:	239	Identity:	67/239 - (28%)
Similarity:	97/239 - (40%)	Gaps:	49/239 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IYNGVEAKFDFWTFLASVWVS-GYHECGGAVIDSRIVLTAAQCVK--NKPVKRITVRVGTPDIYR 80
            |..|..|....|.:..|:... |.|.|||.:|....|||||.|:|  ::|.....:.....::..
Human  1820 IVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNL 1884

  Fly    81 GGRI--IRVTALVVHENYKNWDNDIALLWLEKP-VLSVRVTKIPLATKEPSENEYPSNA------ 136
            ...:  |.|:.|.:...    ..|||||.|.:| |::.:|  :|.....|   :|...|
Human  1885 ESHVQEIEVSRLFLEPT----QADIALLKLSRPAVITDKV--MPACLPSP---DYMVTARTECYI 1940

  Fly   137 -GWGEK--------LLESYVVTRKLQNGVTKIRPRSMCAEELVEPVGEELLCAFYTENDICPGDY 192
             ||||.        |.|:.::.  ::|.|.. ..:.:|||.|..            ..|.|.||.
Human  1941 TGWGETQGTFGTGLLKEAQLLV--IENEVCN-HYKYICAEHLAR------------GTDSCQGDS 1990

  Fly   193 GGPLVLANK----VVGIAVQGHGCGFAVLPSLYTNVFHYLEWIE 232
            |||||...|    :.|:...|.||.....|.:|..|..::.|||
Human  1991 GGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIE 2034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4271	NP_608665.1	Tryp_SPc	19..234	CDD:238113	67/239 (28%)
CG4271	NP_608665.1	Tryp_SPc	19..231	CDD:214473	64/236 (27%)
LPA	NP_005568.2	Kringle	28..105	CDD:278480
		Kringle	142..219	CDD:278480
		Kringle	256..333	CDD:278480
		Kringle	370..447	CDD:278480
		Kringle	484..561	CDD:278480
		Kringle	598..675	CDD:278480
		Kringle	712..789	CDD:278480
		Kringle	826..903	CDD:278480
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:278480
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		KR	1386..1466	CDD:214527
		KR	1500..1581	CDD:214527
		KR	1614..1695	CDD:214527
		Kringle	1720..1799	CDD:278480
		Tryp_SPc	1820..2034	CDD:238113	65/237 (27%)
		Tryp_SPc	1820..2033	CDD:214473	64/236 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910