DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4271 and F11

DIOPT Version :9

Sequence 1:	NP_608665.1	Gene:	CG4271 / 33410	FlyBaseID:	FBgn0031409	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	XP_005262878.1	Gene:	F11 / 2160	HGNCID:	3529	Length:	626	Species:	Homo sapiens

Alignment Length:	218	Identity:	66/218 - (30%)
Similarity:	105/218 - (48%)	Gaps:	31/218 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HECGGAVIDSRIVLTAAQC---VKNKPVKRITVRV-GTPDIYRGGRIIRVTALVVHENYKNWDN- 101
            |.|||::|.::.:||||.|   |::..:.|:...: ...:|........|..:::|:.||..::
Human   415 HLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESG 479

  Fly   102 -DIALLWLEKPVLSVRVTKIPLATKEPSENE----YPS--NAGWGEKLLESYVVTRKLQNGVTKI 159
             |||||.||..| :...::.|:..  ||:.:    |..  ..|||.:.|..     |:||.:.|.
Human   480 YDIALLKLETTV-NYTDSQRPICL--PSKGDRNVIYTDCWVTGWGYRKLRD-----KIQNTLQKA 536

  Fly   160 RPRSMCAEELVE-----PVGEELLCAFYTE--NDICPGDYGGPLVLANK----VVGIAVQGHGCG 213
            :...:..||..:     .:..:::||.|.|  .|.|.||.||||...:.    :|||...|.||.
Human   537 KIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA 601

  Fly   214 FAVLPSLYTNVFHYLEWIEENAE 236
            ....|.:||||..|::||.|..:
Human   602 QRERPGVYTNVVEYVDWILEKTQ 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4271	NP_608665.1	Tryp_SPc	19..234	CDD:238113	65/214 (30%)
CG4271	NP_608665.1	Tryp_SPc	19..231	CDD:214473	63/211 (30%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519
		APPLE	291..375	CDD:128519
		Tryp_SPc	388..619	CDD:214473	63/211 (30%)
		Tryp_SPc	389..619	CDD:238113	63/211 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910