Protein Alignment Wdr62 and Wdr62

DIOPT Version :10

• Sequence 1: NP_001259886.1
• Gene: Wdr62 / 33367
• FlyBaseID: FBgn0031374
• Length: 2397
• Species: Drosophila melanogaster
• Sequence 2: NP_001178552.2
• Gene: Wdr62 / 308492
• RGDID: 1306714
• Length: 1551
• Species: Rattus norvegicus
• Alignment Length: 1641
• Identity: 524/1641 - (31%)
• Similarity: 767/1641 - (46%)
• Gaps: 346/1641 - (21%)

  Fly     4 ASLSASTPTLSTLHHQRMALQSQSQSPLASP--------LTPSPSSVFGSPKFPANYERSEKIKL 60
            :|:.|..|          |.::||..|.|.|        |..:|....           ..::.|
  Rat    20 SSVMAGVP----------ARRNQSSPPPAPPLCLRRRTRLAAAPEDTV-----------QNRVTL 63

  Fly    61 KKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVA 125
            :||||:|..:::.|...|.:|.:||.|||.||:.|.|...|.::.||:||:.:::|||..|:|:.
  Rat    64 EKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIV 128

  Fly   126 TGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVN 190
            |||.|..||:::|::|..          :.|||.:.|||.|.||||||..|::||:|.||||::|
  Rat   129 TGENGHRPAVRIWDVEEK----------TQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLN 183

  Fly   191 VFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYK--DPIPLMGRSAIL 253
            |:||:.::.:||||:|.:|.|:.||||.|||||||||||::|:||...:.|  ..:||:|||.||
  Rat   184 VWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTMPLVGRSGIL 248

  Fly   254 GDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGC 318
            |:|.:|.||.||||:|..|.:|:.::..|.|.:|:.:|:||||:..:.:.::|:||::..|..||
  Rat   249 GELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGC 313

  Fly   319 AESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCV 383
            .:.|:|||.:.:|.|:|.||:.||||:|||||:..:.:.....:|.:||.:|:.||.....:|||
  Rat   314 TDGIVRIFQAHSLLYLTNLPKPHYLGIDVAQGLDSSFLFHRKAEAVYPDTVALTFDPIHQWLSCV 378

  Fly   384 YNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQT-LPEECFVTCSSDDTIRV 447
            |.|||:||||::||:.|.|..|.|:||:.:|.||..|   |.|..:. ||...|:|||||:|||.
  Rat   379 YKDHSVYIWDVKDINEVSKIWSELFHSSFVWNVEVYP---EFEDQRACLPSGTFLTCSSDNTIRF 440

  Fly   448 WGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS---YDGRNGVRCIKIS 509
            |.:|..::.. :|:||:|..|||:||.::::|.::|.  |.|...|:.:   .|.:.|||.:::|
  Rat   441 WNMDSGSDTQ-WRKNIFSDSLLKVVYVENDIQHLQDM--SHFPDRGSENGTPMDMKAGVRVMQVS 502

  Fly   510 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDV 574
            |:.||||||||.||:|::.|..:..|..:|||::||||||||..:....|||||||||||||.:|
  Rat   503 PDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNV 567

  Fly   575 AQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTT 635
            .:||.|.|||||||||||:|||.|. .:.|||||||||||.|||.|    |..|:|..:.:.|||
  Rat   568 EKNYNLEQTLDDHSSSITAIKFAGT-RDVQMISCGADKSIYFRSAQQTSDGLHFVRTHHVAEKTT 631

  Fly   636 LYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDK 700
            ||||::|...|::..||||||||||.|.:.||.|.:|||..|||||:|:.:||||.::||||:||
  Rat   632 LYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDK 696

  Fly   701 TLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARM---- 761
            :::|.|:||.||:|:|:||||:|||:|||.||||||:.|||.|:|||.:..::...|:..:
  Rat   697 SISVIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLMEIN 761

  Fly   762 --SQQRL-----------RSGHAPLPRPLAPISPPDGI------------VLESPTSEIEQPQLQ 801
              .||.|           :...|..|..:..:||.:..            .|::|:.|...|  .
  Rat   762 HQEQQHLPKDQKWSGPPSQETSASTPSEIRSLSPGEQTEDEMEEECEPEETLKTPSKESLDP--D 824

  Fly   802 PKFGVAERFSDVGQLPQWAMRKAAAD--SDSGALSIP---TPSGGSA---------TVPGMHAAS 852
            |:..:..     |:||.||.|....|  :||.|....   .|.|..|         |:....|..
  Rat   825 PRCLLTN-----GKLPLWAKRLLGDDDVTDSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWALD 884

  Fly   853 SM------GNLSSS-----PSQQMTGL---------------------------APR--ARGRWA 877
            |.      |||..|     ..|.:.||                           :|:  :||..:
  Rat   885 SYFTPMKPGNLEDSVLDSVEPQNLAGLLSECSPENGHTAPGEGLVSYLCHSESGSPKEDSRGHPS 949

  Fly   878 QRSTQLETADDLRSNSESPLGTVSSVGGH--------SGVNVQTSD----YNSASSKDITYNQTY 930
            ....|.|..:.......||...|:..|.|        :|...|..|    .:|.||||
  Rat   950 YLPLQREGTETRELILCSPEVEVTVTGMHREYYEEAEAGPEDQQGDSYLRVSSVSSKD------- 1007

  Fly   931 LSEDSSIDSGMETRRGELKFIGS------SNNGTVVTVSSV---SSIAVSASNGAMSTGSGAAQQ 986
              :....|||......|..|..:      ::.|..:|::..   ||....|..|....|:|:..
  Rat  1008 --QSPPEDSGESEAELECSFAAAHVSAPRTDPGPHLTMTGKPEHSSTDELAQPGVPGLGNGSLP- 1069

  Fly   987 RLQLPDKRLKPGLRFDTHTHDHDGDVEDI---SDGERTSSDHGMFYNNLAPSTPTDFKVTAMNED 1048
              |.|::.......|:|.|   |...|::   |.|:...|:...::.|...|..|.|........
  Rat  1070 --QTPEQEKFLRHHFETLT---DAPAEELFPGSLGDIKISETDDYFFNPRLSISTQFLSRLQKTS 1129

  Fly  1049 --------ELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAE--- 1102
                    .|.||...|...:.|.|.....|.. |:.:.:|.||.....:....||.|....
  Rat  1130 RFPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRA-GTGYMSSDGTNVLSGQMAEETPEASCLPTPP 1193

  Fly  1103 -RSLAS-----------------TLG---GSSENLPQSSTNSFL------HAAL--------PEG 1132
             ..|||                 |.|   |..:::|..|..|:|      ||.:        .||
  Rat  1194 ITGLASCVPPSSVIPTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRSTSLGDSEG 1258

  Fly  1133 P---GLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEE--------------LL 1180
            |   .|..|:.:..|.            |:...|.||.....:|.|..|              |.
  Rat  1259 PVTGELPRPLHKPVSP------------GQEPQAVPTTVALTSSVKGHEPALPAWGNHEARASLR 1311

  Fly  1181 QVINKVKQQLENGTRKNGNTR-----------LNAIAEVGHRPLRGSHSISDLSLAANLDGSRNA 1234
            ..::.|.:||.:..:....|.           .:....|..........:|.|.|.:::...:.:
  Rat  1312 LTLSSVCEQLLSPPQLEPPTTPVWSQEAVDVPPSMAVTVASFSAPSPEDMSTLGLHSSVFLPKTS 1376

  Fly  1235 GGGPGRYQKPVDSHDTSQYTSPQN-------TTATAAPTNTQQQIQPPVQQQYQIPKEP-HQQAQ 1291
            ..||              .|.|.:       .|.:..|.:|...::|........|..| |....
  Rat  1377 ASGP--------------LTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEP 1427

  Fly  1292 QQHQQYAPPASQQFFNCAAPKSKLQQNFQ-----------------TMRQVQQHYPP---YPHH- 1335
            .:..:..||...:..:..:...:||..||                 ..:|.|.....   :.||
  Rat  1428 GRRAEVPPPGPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQ 1492

  Fly  1336 ------VGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSI 1394
                  ||...:.||..:|..|..:..|....:....|                         ::
  Rat  1493 LEASNCVGAASVAPPLTLPSPGPPSPPTLCPLASPNLQ-------------------------AL 1532

  Fly  1395 LKHYKSCPVSPVHEEV 1410
            |:||....|..|..:|
  Rat  1533 LEHYSELLVQAVRRKV 1548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	<73..236	CDD:441893	79/162 (49%)
		WD40 repeat	73..107	CDD:293791	13/33 (39%)
		WD40 repeat	113..161	CDD:293791	16/47 (34%)
		WD40	156..573	CDD:475233	203/422 (48%)
		WD40 repeat	167..207	CDD:293791	22/39 (56%)
		WD40 repeat	209..285	CDD:293791	41/77 (53%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	22/53 (42%)
		WD40	<437..750	CDD:441893	177/319 (55%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	24/43 (56%)
		WD40 repeat	637..672	CDD:293791	19/34 (56%)
		WD40 repeat	679..717	CDD:293791	21/37 (57%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
Wdr62	NP_001178552.2	WD40	3..519	CDD:441893	208/512 (41%)
		WD40 repeat	118..154	CDD:293791	15/35 (43%)
		WD40 repeat	159..195	CDD:293791	14/35 (40%)
		WD40 repeat	203..237	CDD:293791	17/33 (52%)
		WD40 repeat	255..286	CDD:293791	17/32 (53%)
		WD40 repeat	292..342	CDD:293791	16/49 (33%)
		WD40	<365..745	CDD:441893	198/387 (51%)
		WD40 repeat	409..468	CDD:293791	27/59 (46%)
		WD40 repeat	499..533	CDD:293791	13/36 (36%)
		WD40 repeat	538..579	CDD:293791	19/40 (48%)
		WD40 repeat	585..627	CDD:293791	28/41 (68%)
		WD40 repeat	632..668	CDD:293791	16/39 (41%)
		WD40 repeat	676..713	CDD:293791	20/36 (56%)
		Atrophin-1	1178..>1439	CDD:460830	50/309 (16%)