Protein Alignment Wdr62 and Wdr62

DIOPT Version :10

• Sequence 1: NP_001259886.1
• Gene: Wdr62 / 33367
• FlyBaseID: FBgn0031374
• Length: 2397
• Species: Drosophila melanogaster
• Sequence 2: XP_061517645.1
• Gene: Wdr62 / 1280252
• VectorBaseID: AGAMI1_001931
• Length: 2576
• Species: Anopheles gambiae
• Alignment Length: 2756
• Identity: 1239/2756 - (44%)
• Similarity: 1571/2756 - (57%)
• Gaps: 618/2756 - (22%)

  Fly    51 NYE-RSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTS 114
            ||| .:.:|||||:|||||||:|.||||..:|:|||||||||||||:|:.:|.:|:||::||.|:
Mosquito    16 NYEGLNNRIKLKKILGLTVCSSAGLDVSSTTGVLAYPAGCTVVLFNSKKLSQNFLLNTTKKAITA 80

  Fly   115 VAFSRCGRYVATGECGINPAIKVWELETP-----NGSLEHCSGGSVVAEFVDHKYAVTCVAFSPT 174
            ||:|.||||:||||||.||:||||||:..     .|::|:.:.||:||||..|||||:|||||||
Mosquito    81 VAYSECGRYLATGECGHNPSIKVWELDASGGPGGGGAIENGAAGSIVAEFSGHKYAVSCVAFSPT 145

  Fly   175 GKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRK 239
            ||||||||||||.|||||||:||||:||||:::||.||.|||||:|||||||||||||||||.||
Mosquito   146 GKYLVSVGSQHDNIVNVFDWKANLKIASNKVTAKVVAVSFSEDGNYFVTVGNRHVKYWYLEGSRK 210

  Fly   240 YKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNA 304
            ||:||||||||||||:||:|||||||||||..|||||||||.||||||::||||||||.|||..|
Mosquito   211 YKEPIPLMGRSAILGELRNNDFCAVACGKGEMAESTYAITRNGHLVEFNARRLLDKWVMCRTNAA 275

  Fly   305 NCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCI 369
            ||:..:.::|||||||:|:|:||:.||||:|||||||:||||||||:.|||:|:|||.||:||.|
Mosquito   276 NCMVASTKYILVGCAEAIVRVFNAETLEYITTLPRTHFLGVDVAQGVHINHMMAVPQNAKYPDTI 340

  Fly   370 AMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQ----- 429
            |:|:||.||||:||||||||||||||||.|||||.||||||.|||||||||::.:::..|
Mosquito   341 AIVYDEARSKVTCVYNDHSLYIWDLRDIRRVGKSQSFLYHSACIWGVETVPFSYQQQLRQHNGGA 405

  Fly   430 ------TLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSL 488
                  |||.:||:|||||||||||.:|.|..|::||:|||||||||::|.||||.||||..:.:
Mosquito   406 ANGAGDTLPSDCFMTCSSDDTIRVWDVDSCETNEVYRKNIYSKELLKVLYIDDELNFIKDTDNPI 470

  Fly   489 FDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNE 553
            .....|||||||||||||||||:.:.||:|||.||||:|:|.||:|:||||||:||||||||:||
Mosquito   471 HSTEKNSSYDGRNGVRCIKISPDSRQLATGDRSGNIRIYNLSNLKLITTIEAHDSEVLCLEYTNE 535

  Fly   554 KIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRS 618
            ||||:||||||||||||:||...||.:|||||||||||||::|:|||..|||:||||||||:||.
Mosquito   536 KIERRLLASASRDRLIHIFDCEANYRILQTLDDHSSSITSVRFIGAGKQFQMVSCGADKSIIFRH 600

  Fly   619 FQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIK 683
            ||.|:|:||.|.|||.||||||||||:|||||||||||:|||.|||||.||||||||||||||||
Mosquito   601 FQNNVFLRGNNCSGKNTLYDMEVDSNSKHILTACQDRNIRVYSTQNAKHTKTFKGSHSDEGSLIK 665

  Fly   684 LSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 748
            :|||.||||:|||||||||:|||||||||||||||||||||||||||||::|||||||||:||||
Mosquito   666 VSLDLSGIYIATSCTDKTLSVYDYYSNECMARMYGHSELVTGLKFTNDCKYLISASGDGCVFIWQ 730

  Fly   749 VPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFG-------- 805
            ||||||||||||:|||.||||..|:||.|.|.:|....:|..|......|....:||
Mosquito   731 VPHDMIVTMQARLSQQALRSGLQPIPRTLQPTNPFTDAILNHPQPTPPAPSSVSEFGSPPNSAFL 795

  Fly   806 -------VAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQ 863
                   ...||||||||||||.||.:.|..|   |.|.                   |.|||||
Mosquito   796 VDDAPGTPGYRFSDVGQLPQWAKRKPSEDLQS---SSPV-------------------LGSSPSQ 838

  Fly   864 ---QMTGLAPRARGRWAQRST--QLETADDLRSNSE-SPLGTVSSVGGHS--------------- 907
               ...||||:.||||.|:..  |||...|||:..| ||||| :.|||.|
Mosquito   839 TGANFGGLAPKPRGRWGQKGVGGQLEDPFDLRNIVESSPLGT-TFVGGDSRQQPTTPQPSATAAT 902

  Fly   908 -------GVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSV 965
                   ..|..||.|||:.|||: |:..|||||||||||.|.||.:|    ||.....:|.:.
Mosquito   903 GQPIHPPATNTPTSGYNSSGSKDV-YSNAYLSEDSSIDSGRENRRPDL----SSFLHKKITETK- 961

  Fly   966 SSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGM-FY 1029
               |:::.|...:|                           :|||||||||||||||||||| :|
Mosquito   962 ---ALNSLNSESNT---------------------------EHDGDVEDISDGERTSSDHGMVYY 996

  Fly  1030 NNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLT---PSALSGNGSSHTASTGTGTSDTED 1091
            .:.|||||||||:..::.:|||||:||||.||.||.|.   .||.||        |||||||.||
Mosquito   997 PSAAPSTPTDFKINEIDTNELRKSIRRQKLEKQGLSLAAQFQSAASG--------TGTGTSDDED 1053

  Fly  1092 EGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTE 1156
            ||||||.:||:||||||||||||::||.::::||.|.| :|||..:..|| ..:|:|:|||||.:
Mosquito  1054 EGSTPSGDNADRSLASTLGGSSESIPQQTSSTFLQAVL-DGPGSLSDRER-SQARKSMSAKHNND 1116

  Fly  1157 NGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENG----TRKNGNTRLN-AIAEVGHRP-LRG 1215
                .....:|:||:.:.|||||::|||:.|.:||||    .::.....|| |..:||:|. ||.
Mosquito  1117 ----AKITTSISKSFANNKKEELMKVINEAKAKLENGIMFHNKREIKPPLNYAQFKVGYRSGLRA 1177

  Fly  1216 SHSISDLSLAANLDGSRNAGGGPGRYQK-PVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQ 1279
            ||||||||.:.|:     :|..|.|.|: .|||:                       :.|.|...
Mosquito  1178 SHSISDLSHSMNM-----SGASPNRTQRIEVDSN-----------------------LGPRVYHP 1214

  Fly  1280 YQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPP 1344
            ......|:..|...|     |.|..|.:.|||:|||.||...|.|:||..||||..||:::  |.
Mosquito  1215 GAGAAGPYGGAPGMH-----PNSSNFLHSAAPRSKLAQNCMLMNQIQQELPPYPRDVGIYE--PG 1272

  Fly  1345 PGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEE 1409
            |.                       |:..:.........||...|:.|.|||:||||||||||||
Mosquito  1273 PA-----------------------QRPDKLDLVELPPVPADKLRKHPGILKNYKSCPVSPVHEE 1314

  Fly  1410 VEWSAEG-------NERGAL--LGEPKRHSVYADDARTILDMIHADTEKMIDEITRKYGDLDE-- 1463
            .|||:..       |::..|  .|...|||:|.:||:|||.|||:||||||.|||.||||||:
Mosquito  1315 QEWSSPSNHDESSHNQQKTLDRTGRQMRHSMYYEDAKTILSMIHSDTEKMIREITSKYGDLDDIQ 1379

  Fly  1464 --------------PGIPA----SYSMPANLR--------NLGGLGS-----TGDST-------- 1489
                          |..|:    |.|.|.:.:        ..|.|..     :.||.
Mosquito  1380 PTAKVKEEGEETVPPPPPSTVAKSGSKPPDTKASTAREHHEHGFLSEDEPNFSSDSLEDCSLDLD 1444

  Fly  1490 --------------------PTGRT---------TQYYVYREFYQCE-----RKVSLSDILQPEQ 1520
                                |..||         :.|::|.:..|..     |.|||||||..|:
Mosquito  1445 LERQGLPVPARKKQTCAKHHPAKRTPLTLPKRSVSDYFIYDQAPQGPSEIPYRNVSLSDILDDEE 1509

  Fly  1521 FAASQRRLDEARFLETQRHSSASFFLTGQQ-----SQESLSLLSD--GDGPGSYCNSLESVLSDE 1578
            ..    |..|.||||||||||||||| |||     |||  |:|||  |.|..|:|||:||:|||:
Mosquito  1510 AI----RQAENRFLETQRHSSASFFL-GQQYPTRKSQE--SILSDEYGSGGVSFCNSMESILSDD 1567

  Fly  1579 SDCQSAPLEYPQTQVAVLQQR------------HAGIRN------FIIHG---PVSKSYGNSPNA 1622
            |:|:|||||       ||..|            |...||      :.:.|   ..|||||:||||
Mosquito  1568 SECKSAPLE-------VLFGRIRRDHHGQAGHGHGAGRNASGNFEYKLEGLGCATSKSYGSSPNA 1625

  Fly  1623 YGSFDYYMRQQ--HSTTT----------DSFDVTGYN---LEPLKPLPSSKTYPR-IAQVQAS-- 1669
            ...|||||:..  |:||.          ||.:..|:.   .:....:|:|.:||| :..:.||
Mosquito  1626 GCGFDYYMQGNYFHATTATDSSYFGMVQDSLEYGGHERRVRQGAPGMPTSMSYPRFLPSLAASAA 1690

  Fly  1670 --------------------ENIPTLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQ------- 1707
                                :.||:|.||..||.....||||.|||.||:|.||||:.
Mosquito  1691 APLSSGREELLFNETFEEGEDFIPSLTSKAAQYGGATVKSLSKDFANQRKQMNSNPLYNCNDGNG 1755

  Fly  1708 -----------SGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQK------QKSQSRTASVVQ 1755
                       :|| ||:||.:...........::..|.|.:...:|      :....|.|...:
Mosquito  1756 VAAAAAAVGAGNGD-LFIRKTVNATNQHQITRSDIFGTESSVYVMKKSCSFEIEMGGRRIARNSK 1819

  Fly  1756 QFEHNLQKFEKEKQRERE----QQRRPAMRSSVSSGALAGGSTTQSCLKKVSRFDTSESSRRATS 1816
            :||.|||:||:|:::..|    ||              .||:.....:.    .....:.||:.|
Mosquito  1820 KFEQNLQRFEQERKQSNERFLHQQ--------------FGGTLEMDYVP----HKPPVAHRRSAS 1866

  Fly  1817 VRQKNRPKISVRFNT-VSQIKYTP----------SAKRERQARE----EEPPEME-----VGSLP 1861
            ::.:.|.:...:||| :.|:..:|          ...|:...|:    .:||..|     ||..|
Mosquito  1867 MKGRGRVRSKEKFNTIIGQMSNSPGQCDEPAMIGGKLRDFVNRDFVMPNKPPSSEVMSVSVGGAP 1931

  Fly  1862 --SDYG-ERSFEMYFAENGNAPENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDNAGKISG 1923
              .|.| |:|||:|.||.|.:.:  :||.:|:|.:|.:..|.|     .:|....:||..|.:.|
Mosquito  1932 RRCDIGEEKSFEVYVAEKGVSED--DNMDSLELLSKAKSAACV-----RKENSTDSLDAPGTVEG 1989

  Fly  1924 KGGSG-----KGKGA-----------------------------------------GSSTS---H 1939
            ....|     :|..|                                         |..||   :
Mosquito  1990 VTEIGVEALEEGMDAAPEDEDVNAAVDALAAEEALELPRKSLTQGATSELEKLIDRGLLTSGEYN 2054

  Fly  1940 QCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARGEDPTE 2004
            :..:|.|||||:.||:.:||.|:||.|.|.|.|:|||||:.::||||||||.|||.||:    ..
Mosquito  2055 RFLDIEKKIDIVNKLVELEERKLEQERTAKEHRMRPFNCDPRQKGYVKSLTENFDRLAK----DA 2115

  Fly  2005 DEDLASKDASDLCAYARNIRRNCSLPDVLE-STDFTGIYNSQGVELAKEVIADDES--------G 2060
            .|:|.::.:..| |.|| ::||.||||||: ..|....:..:..|...:...||:.        |
Mosquito  2116 QEELENEKSWHL-AKAR-MKRNFSLPDVLDFGADCCCRHAGKCCERRGDGEEDDDDEADECVCCG 2178

  Fly  2061 DPVN-------------------PGITADSADHDGIGQTVVLRMEPGNPKTLNPMPIEESSIRRA 2106
            |..|                   ..:.|.:|....||.:  ...|.|||::|......|||||||
Mosquito  2179 DGCNAYKQKDEEELSEKDENSMAAAVAAVAAAVAAIGMS--HSDEGGNPRSLISAQDSESSIRRA 2241

  Fly  2107 CSLSDLHMG-NFGKPGKSQNGTPQ-KPQVQHRNGNV-SRSASKRN-SLQGK------TGLGASSN 2161
            ||||||.|| .:..|.:|..|:.| ||.|.:||.:. :|:..||: |..||      ||:|..|.
Mosquito  2242 CSLSDLSMGKGYKSPNQSTAGSGQYKPSVSNRNTSTPTRNTPKRSTSSVGKGGASLSTGMGVRSI 2306

  Fly  2162 SMNVLNQGSDSEPE--------------DSNRLRSASNGQGRSNGPIAANRQYSN--KINNVNNN 2210
            |:.:|||.||||.|              ..|::....||.|..:|     .:|.|  ....:.|.
Mosquito  2307 SVGMLNQASDSEAEPAGTRGGLLKPTISSQNKINGTGNGTGPGSG-----GKYINPRSAAGIINR 2366

  Fly  2211 RRKTPN-FSS---ATPMQDDSSSEETPNSTVNN---KPIVPPRPRNLAFDHK-----SKLMINNS 2263
            |:...| :||   :|..||:|||||:|.|||:.   ||.||||||::||:||     |:|.:..:
Mosquito  2367 RKGLQNAYSSVNISTAGQDESSSEESPTSTVSTVPAKPAVPPRPRSIAFEHKRIANASQLNVKKT 2431

  Fly  2264 GSPGG----------------NAKQRSGV---TSTEDFEGTDPEAQV-HNVINKLYTTTQAAMQL 2308
            .:.||                |....:|.   ....|.:..|...|: .|:||:|..||...:||
Mosquito  2432 VTVGGTTTIPADATTNGGSNNNGSSNNGAMLPVKDADLDNADLTNQLCTNIINQLVQTTSTVIQL 2496

  Fly  2309 HANLK-----------NTLLLKELENALIMSRNMLSSITNRQADKTNNGGGGLGVGGSGGLNHDQ 2362
            |..||           |:|:|||||||:||::|||:.:|||              ..:.|:|::.
Mosquito  2497 HQRLKSSDEASINGRNNSLMLKELENAVIMTQNMLTKVTNR--------------NHNDGINNNS 2547

  Fly  2363 LNADNGDYLMMVNNCADLLSNLRTKH 2388
            : ::|.:..:|...|.|:|:.:: ||
Mosquito  2548 M-SNNTNNQIMYEKCVDMLNQVQ-KH 2571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	<73..236	CDD:441893	118/167 (71%)
		WD40 repeat	73..107	CDD:293791	21/33 (64%)
		WD40 repeat	113..161	CDD:293791	30/52 (58%)
		WD40	156..573	CDD:475233	316/427 (74%)
		WD40 repeat	167..207	CDD:293791	34/39 (87%)
		WD40 repeat	209..285	CDD:293791	65/75 (87%)
		WD40 repeat	303..338	CDD:293791	20/34 (59%)
		WD40 repeat	353..407	CDD:293791	42/53 (79%)
		WD40	<437..750	CDD:441893	244/312 (78%)
		WD40 repeat	505..540	CDD:293791	23/34 (68%)
		WD40 repeat	546..586	CDD:293791	31/39 (79%)
		WD40 repeat	591..631	CDD:293791	27/39 (69%)
		WD40 repeat	637..672	CDD:293791	30/34 (88%)
		WD40 repeat	679..717	CDD:293791	33/37 (89%)
		WD40 repeat	723..749	CDD:293791	22/25 (88%)
Wdr62	XP_061517645.1	None