Protein Alignment Wdr62 and mapkbp1

DIOPT Version :10

• Sequence 1: NP_001259886.1
• Gene: Wdr62 / 33367
• FlyBaseID: FBgn0031374
• Length: 2397
• Species: Drosophila melanogaster
• Sequence 2: XP_073784297.1
• Gene: mapkbp1 / 100535386
• ZFINID: ZDB-GENE-120207-1
• Length: 1632
• Species: Danio rerio
• Alignment Length: 1899
• Identity: 558/1899 - (29%)
• Similarity: 835/1899 - (43%)
• Gaps: 473/1899 - (24%)

  Fly    35 LTPSPSSVFGSPKFPANYER-SEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKR 98
            |..|||......|...|.|. |.|:.|:||||:|...:.||...|.|||:||||||.|||.|.|:
Zfish    15 LLRSPSIKLRRSKAGNNKENLSNKVTLEKVLGITSAGSRALACDPHSGLIAYPAGCVVVLLNPKK 79

  Fly    99 QTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHK 163
            ..|.:::|:|||..|:|:||..|:||.|||.|..||::||::          :..:.|||..:||
Zfish    80 NKQHHIINSSRKTITTVSFSPDGKYVVTGESGHMPAVRVWDV----------AERTQVAELQEHK 134

  Fly   164 YAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRH 228
            |.|.||:|||..||:||||.||||||||:.|:.|:.:|:||:||||.||.||:|.|||||.||||
Zfish   135 YGVACVSFSPNSKYIVSVGYQHDMIVNVWAWKKNVVVAANKVSSKVTAVSFSDDSSYFVTAGNRH 199

  Fly   229 VKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRR 291
            ||:|||:..:  |....:||.|||.:||:||:|.|..||||||..|.||:.||..|.|.||:.:|
Zfish   200 VKFWYLDHTKSSKVNATVPLSGRSGLLGELRNNFFSDVACGKGRKASSTFCITTSGLLCEFNDKR 264

  Fly   292 LLDKWVQCR------TTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQG 350
            :|||||:.|      |:.|..:.|.|..|..|||:..:|.|....|.::.|||..|.||.|:|..
Zfish   265 MLDKWVELRKNDSFATSMATSLSVCEDLIFCGCADGTVRAFTPTDLHFICTLPHPHSLGTDIATL 329

  Fly   351 IQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWG 415
            .:.:|:.|..|..::||.:|:.:|.....:||||||||||:||:||:.:|||.:|.||||:|:|.
Zfish   330 TEASHLFSYKQNVRYPDAVAVSYDPSSRWLSCVYNDHSLYVWDVRDLRKVGKVYSALYHSSCVWS 394

  Fly   416 VETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQF 480
            ||..|.:.:.|..:..|.. |::||||:|||:|..|  ..|....||:.|.:|.||:|.|.....
Zfish   395 VEVYPESRDGEQPRLSPGS-FLSCSSDNTIRLWHTD--AQNTSLSRNVISNDLQKIIYMDSNTST 456

  Fly   481 IKDQG---SSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHE 542
            :.|..   ||..:|....:.:.|.|:|.:.:||:..|||||||.|.:|::.|.::..:..::||:
Zfish   457 LLDTDCTISSNSEKVDPQTSENRTGIRTMCVSPDGLHLASGDRNGTLRIHDLESMEEILDVQAHD 521

  Fly   543 SEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMIS 607
            ||:||||||..:...||||:||||||||:.|..:.|.||||||:||||||:::|.......:|||
Zfish   522 SEILCLEYSKPETGLKLLATASRDRLIHILDADKEYSLLQTLDEHSSSITAVRFAANEGKVRMIS 586

  Fly   608 CGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQT 668
            |||||||.||:.|    |..|.|..:...|||||||::|...|:.:..||||::|::...|.||.
Zfish   587 CGADKSIYFRTAQKTEEGTAFTRTHHIVRKTTLYDMDIDPTRKYAVIGCQDRSIRIFNIGNGKQK 651

  Fly   669 KTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCR 733
            |.:|||..::|::||:..||||:||||||:||.::::|:|:.||:|.|:||||:|||:|||||||
Zfish   652 KVYKGSQGEDGTVIKVQTDPSGLYVATSCSDKNISIFDFYTGECVATMFGHSEVVTGMKFTNDCR 716

  Fly   734 HLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQP 798
            |||:.|||.|||:|::..::.:.|:.|:|..:..|      ||:.. :||:.....|...||
Zfish   717 HLITVSGDSCIFVWRLSPELTINMRQRLSDLKQNS------RPVQK-TPPNKQHTLSARKEI--- 771

  Fly   799 QLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQ 863
                                                              |:|..:|.:||...:
Zfish   772 --------------------------------------------------HSAPVIGTMSSDSDK 786

  Fly   864 QMTGLAPRARGRWAQRSTQLETADD----LRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDI 924
            .:            :....:|..|:    |.|.|.:...|.||...|:.:|......:|:|..:
Zfish   787 DV------------EEEEGIEEEDEMFPHLSSGSSAGEDTGSSEEKHNSLNSHMKKQSSSSEHE- 838

  Fly   925 TYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQ 989
                         .||...||...:.:||.:    :.|.|:..:....|              ..
Zfish   839 -------------SSGSRPRRRWSRRMGSID----LKVKSMLDLRQLES--------------FA 872

  Fly   990 LPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSV 1054
            :|        .|.:.:||                         ||..|     .|....:|..::
Zfish   873 MP--------LFPSKSHD-------------------------APKNP-----PAPKNQDLGSTI 899

  Fly  1055 RRQKF-----EKSG------LQLTPSALSGNGSSHTASTGTGTSDTE---DEGSTPSAENAERSL 1105
            ..|..     |::|      :||.|.                |.:||   .||....
Zfish   900 SLQTLAAWMPEENGQTRPHYIQLPPQ----------------TPETEVLYPEGCEDQ-------- 940

  Fly  1106 ASTLGGSS---ENLPQSSTNSFLHAALPE--GPGLTTPMERGGSSRRSISAKHNTENGKSVAAPP 1165
             |:|.||.   :.||.....:.::.. ||  .|.....||.  ||.|..|.:|..|:.:. ..|.
Zfish   941 -SSLAGSEYQVKKLPHGVRCTKVNTC-PEKQSPDSACSMEY--SSSRLSSPEHPGEDSEP-TEPL 1000

  Fly  1166 TITKSYTSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRP------LRGSHSISDLSL 1224
            ::..:.:....|:|       .::.|.|.|||     :....|...|      .|...::|||
Zfish  1001 SVDGNSSELDMEDL-------DEEEEEGLRKN-----DVQTPVPQTPDQEAFLKRHFANLSDL-- 1051

  Fly  1225 AANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQ---------IQPPVQQQY 1280
                    |....|.|....:....:|::.|..:.:.||.|.::.:.         ::|.|.:..
Zfish  1052 --------NNPASPTRVTPNISDSKSSKFLSQNSPSRTAFPFSSNKNSDIKTTSGVVRPLVSEVR 1108

  Fly  1281 QIPKEPHQQAQQQHQQYAPPASQQFF-----------NCAAPKSKLQQNFQT---MRQVQQHYPP 1331
            .:.:......||:.|.....:.|:..           ...:|.:|...|..:   ||:.|.
Zfish  1109 PLMENKSPFKQQESQSSERSSCQRLIQKKRTPVMDSRRLISPVAKAAANHNSSAGMRKAQS---- 1169

  Fly  1332 YPHHVGVH------------QIHPP-----------PGVPFGGSAAGSTSAM------------- 1360
             .|::...            ::||.           |.||.    ...|||:
Zfish  1170 -IHNISSEVDLVQTSTRPSKEVHPQPQASERPRRSLPTVPL----ISPTSALPKDITTTPTKLKA 1229

  Fly  1361 RSHSQPQNRQQ-------------------QQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPV 1406
            ||:..|.....                   :......|...:.:.|:|.:.      :|.|.:||
Zfish  1230 RSYMSPTTSSMAKISRSASMGDNLNVVEIGEDTGSSDRGSCSDSSNSRSSS------QSKPTTPV 1288

  Fly  1407 HEEVEW-------------------------SAEGNERG---ALLGEPKRHSVYADDARTILDMI 1443
            .::|.|                         |...:.:|   .|.|          .||.:|
Zfish  1289 TQQVSWPNTSASPFPGPYTPHAAVVPTLSAGSGNSSSKGFQVKLTG----------SARPLL--- 1340

  Fly  1444 HADTEKMIDEITRKYGDLDEPGI----PASYS-----------MPANLRNLGGLGSTGDSTPTGR 1493
            |.|....:.         |:|.:    |:|.|           .|....:|.|    ....|:|
Zfish  1341 HIDIPNPLP---------DKPFLSSLSPSSKSPKVAQKEPLSRNPTTTPSLAG----AVQLPSG- 1391

  Fly  1494 TTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLL 1558
                     ..|....|.||....|:|...|...:..    :|:..:........:.|:|
Zfish  1392 ---------IIQPVAAVHLSPSETPDQIELSMVLVPS----QTKNFTDVELQPDAEPSKE----- 1438

  Fly  1559 SDGDGPGSYCN--SLESVLSDESDCQSAPLEYPQ---TQVAVLQQRHAGI-RNFIIHG--PVSKS 1615
               |...:.|:  |..|:|...|..|.:.|...|   |..:||.:  .|: ::|...|  |:|.|
Zfish  1439 ---DTSEAECSPISQSSLLQSTSGAQDSGLPGHQSSLTPSSVLLR--LGLSKHFFTKGLWPLSPS 1498

  Fly  1616 YGNSPNAYGS--FDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIPTLRSK 1678
            ..:..:...|  .::|..|..|.:.|:..:....|:        .::.|.:.:....:|.|..|:
Zfish  1499 TSSITSFISSPPINHYHLQDTSLSVDACRLVASELQ--------SSFKRASHLYKMLSISTDSSE 1555

  Fly  1679 NKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQK 1743
            .:|..|.|   ||..|...|.:.|..|           |..|.|| .:...|.|.||::.:   .
Zfish  1556 EQQEMSRV---LSEAFEAMRDELNCLP-----------PYTPPPP-KSPSANAVHTLANSD---P 1602

  Fly  1744 QKSQSRTASVVQQF 1757
            .....||.::::|:
Zfish  1603 TLGDDRTLALLEQY 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	<73..236	CDD:441893	91/162 (56%)
		WD40 repeat	73..107	CDD:293791	18/33 (55%)
		WD40 repeat	113..161	CDD:293791	18/47 (38%)
		WD40	156..573	CDD:475233	203/427 (48%)
		WD40 repeat	167..207	CDD:293791	24/39 (62%)
		WD40 repeat	209..285	CDD:293791	44/77 (57%)
		WD40 repeat	303..338	CDD:293791	11/34 (32%)
		WD40 repeat	353..407	CDD:293791	25/53 (47%)
		WD40	<437..750	CDD:441893	156/319 (49%)
		WD40 repeat	505..540	CDD:293791	12/34 (35%)
		WD40 repeat	546..586	CDD:293791	25/39 (64%)
		WD40 repeat	591..631	CDD:293791	19/43 (44%)
		WD40 repeat	637..672	CDD:293791	14/34 (41%)
		WD40 repeat	679..717	CDD:293791	20/37 (54%)
		WD40 repeat	723..749	CDD:293791	20/25 (80%)
mapkbp1	XP_073784297.1	None