DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31663 and Mfsd6

DIOPT Version :9

Sequence 1:	NP_001259884.1	Gene:	CG31663 / 33363	FlyBaseID:	FBgn0051663	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001100381.1	Gene:	Mfsd6 / 301388	RGDID:	1562317	Length:	794	Species:	Rattus norvegicus

Alignment Length:	918	Identity:	185/918 - (20%)
Similarity:	326/918 - (35%)	Gaps:	278/918 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ATDPVVSEKVELSRFGEFCQRRGINPNLIMLKITLFVMYGATSSLLPYLTIHMQSIGLTVEEIAI 74
            :|:.....:.|:....:.|.:  ||.:|::.|:..|..|.|..||.|.|.::.:.:|::..:..:
  Rat    44 STETSAIPEEEIDWIEKHCVK--INNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGL 106

  Fly    75 IYLALPFTTFLSPPITGFLVDKFGKYKPVVVMSLLLNAIFHHSLLFIPQQE---IPGVVPSAFVL 136
            :.....|..|.|.|..|.:.|:|.|.|.|::.|||...:|:..:.|:....   ||.:.|:|
  Rat   107 LVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCIPKIPPTA--- 168

  Fly   137 RHPDSGDIEVWWSPCPSRECPEEPELELAVHQCVDYCLMQEQVNPQLYTNTPAYDVRPAATTSTT 201
             ||                                             ||
  Rat   169 -HP---------------------------------------------TN--------------- 172

  Fly   202 QRSQLTATTARTTTMEPSSESSSSPAPTTSTTTSPASSLPALFATQTRSRYQEVLNMSSTMFPPM 266
                    .:...|:.|.:                 ||..|.|.|..:|..:..|..|:|
  Rat   173 --------VSHPVTILPMN-----------------SSTVAFFTTPPKSLEKRSLLFSAT----- 207

  Fly   267 SQLKDALEEGVEPGQSSSAELSAMSMQGLNLTNSSQKKLLWSSWVHSDNDDATYFMLQMHPDLAD 331
                       ||                   |.|...||           :|...|...|.|..
  Rat   208 -----------EP-------------------NISNIDLL-----------STALTLTTEPTLRP 231

  Fly   332 PTEQLGMEIEQDANETVTDILQRFGHDYLVRGNINLTDMDDLDLRCGGLVRRTNMTNIASGAVEC 396
            .||.:        ...|||::       |....:.|..       .|.:.|.|.:..:.:
  Rat   232 QTEGI--------THHVTDLI-------LNTSTVTLPP-------TGNVTRETTIAVVTT----- 269

  Fly   397 MMQRCTFTLNAPEICPPDYKETDEIIFWVYFLLRFLATTMLSAGVTIMDPIALTMIEKYGGDFGR 461
                 |.:|.:.::.....::..|.||.|..::..:.....::.|||:|.:.|..:.|:...:|.
  Rat   270 -----TKSLPSDQVTLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGL 329

  Fly   462 ERLFSSIGMAIFSPITGIMIDYSS-----RGLG-----YTDYSAAFYTYDVLLVISTMSVLMMP- 515
            :|::.|:|..:.....||.|||:.     .|.|     |.:|...|..:.||:   ||::::..
  Rat   330 QRMWGSLGWGLAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQIVFIVFGVLM---TMALIVATQ 391

  Fly   516 -------------LGEKLPADNVFRD--------------------LWNLLKMPHVIAFICFLFV 547
                         .|:::....|.||                    .|:|:|:...:.:...|||
  Rat   392 FRFRYNHFNNSDGKGKEMEIPQVERDNSTESSEETPTAATHSQAFNFWDLIKLLCSVQYGSVLFV 456

  Fly   548 ---LGNFWGFIESFLFLYLKELGAPNYLLGITITVGTVSSIPFLYGAEKITRIFGHVNLIIIAFF 609
               :|..:||:.:||:.:|::|.....|.|:...:..||.:...:.:.|:..:.||:.::.|...
  Rat   457 AWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLA 521

  Fly   610 SHAGRLVGYSFIETAWWCFPFEAMESLSCHLMWVAAATYCSILAPKSLLATLIGVLGMAHFSLGR 674
            .:..|.:..|::|.||...|.|.::.::...:|.|..:|.|...|..|..:..|:|...|..|||
  Rat   522 CNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 586

  Fly   675 GSGSFTGGLLIGQFGTRDAFRYMGLLAVVGGIAYGLLHLIWL----------------------- 716
            |.|:..||:|:..||....||.:|:..:|..:.:.|:.  ||
  Rat   587 GCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ--WLAVPDEEEDKTMLAERIPVPSSPV 649

  Fly   717 --RKFDHTTEESEEEVEAVEA----------GETEKLTEPATKEQGTSMSLERLSLMIKYNQIGS 769
              ...|...:::|:.:..:||          .|.|.:.:||   .|.|.| ..::.:....|:..
  Rat   650 PIATIDLVQQQTEDVMPHIEARLPPKKTKHQEEQEDVNKPA---WGVSSS-PWVTFVYALYQVKE 710

  Fly   770 LSSLPRGSRADIHDHLSVRRSSYNVESLRGVPRHGNIGSASKVDILRSALEINHKSSNNSMLSKA 834
            |..|.|.|||.            .::.|:|:..:..:..|...   :.|....|..|..:.||..
  Rat   711 LMRLTRDSRAS------------EIQPLQGIHENRQVSPAGGA---QCAPHETHSDSPRNQLSPD 760

  Fly   835 DNKTSNQS 842
            ...:..||
  Rat   761 TAASQMQS 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31663	NP_001259884.1	MFS_1_like	36..111	CDD:289593	23/74 (31%)
		MFS	<423..711	CDD:119392	81/334 (24%)
		MFS_1	<423..678	CDD:284993	71/301 (24%)
Mfsd6	NP_001100381.1	MFS_1_like	68..143	CDD:289593	23/74 (31%)
		MFS_1	<77..169	CDD:284993	27/95 (28%)
		TMIE	366..>395	CDD:292657	7/31 (23%)
		MFS_1	453..>651	CDD:284993	51/199 (26%)
		MFS	453..>623	CDD:119392	48/169 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810