DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31663 and MFSD6L

DIOPT Version :9

Sequence 1:	NP_001259884.1	Gene:	CG31663 / 33363	FlyBaseID:	FBgn0051663	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_689812.3	Gene:	MFSD6L / 162387	HGNCID:	26656	Length:	586	Species:	Homo sapiens

Alignment Length:	736	Identity:	133/736 - (18%)
Similarity:	243/736 - (33%)	Gaps:	236/736 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PYLTIHMQSIGLTVEEIAIIYLALPFTTFLSPPITGFLVDKFGKYKPVVVMSLL--LNAIFHHSL 118
            |:||::::.:||....:..:............|:..||...:.|.:.:::.|||  :.|    ||
Human    32 PFLTLYLRQLGLAAPWVGTLMGTKHLIAAFWAPVCAFLAKSYRKRRALLIGSLLGSVGA----SL 92

  Fly   119 LFIPQQEIPGVVPSAFVLRHPDSGDIEVWWSPCPSRECPEEPELELAVHQCVDYCLMQEQVNPQL 183
            |.:       :||..      |...:..   ||..
Human    93 LMV-------LVPPV------DKNRVHF---PCNG------------------------------ 111

  Fly   184 YTNTPAYDVRPAATTSTTQRSQLTATTARTTTMEPSSESSSSPAPTTSTTTSPASSLPALFATQT 248
                      .:..|||.....:|.....|:..|   .:||.||..|:....|....|
Human   112 ----------SSGLTSTDALPGVTLPVNITSAQE---SASSHPAKRTAEVEMPGFRNP------- 156

  Fly   249 RSRYQEVLNMSSTMFPPMSQLKDALEEGVEPGQSSSAELS------AMSMQGLNLTNSSQKKLLW 307
                                          ||:|......      |.|::|...|:.:....:.
Human   157 ------------------------------PGESDRETFRDLHVYLAPSVEGARTTSQALLHPVT 191

  Fly   308 SSWVHSDNDDATYFMLQMHPDLADPTEQLGMEIEQDANETVTDIL---QRFGHDYLVRGNINLTD 369
            |.             |:.||          .|:..:..:|...:|   :..|:...:.|......
Human   192 SG-------------LKDHP----------WEVTFEVVKTALPLLPGGKGPGNPANLSGTKGKAW 233

  Fly   370 MDDLDLRCGGLVRRTNMTNIASGAVECMMQRCTFTLNAP--EICPPDYKETDEII--------FW 424
            ..||.|..   :|||.:.::.|.|...:       |.||  ::......|..:.:        .|
Human   234 AFDLSLEA---LRRTFILSLGSVAFWEL-------LTAPLEQVADDSLYEFLDFVDATDRYRSLW 288

  Fly   425 VYFLLRFLATTMLSAGVTIMDPIALTMIEKYGGDFGRERLFSSIGMAIFSPITGIMIDYSSRGLG 489
            |:.||.      :||||     ..:|                    |:...:...::....||:.
Human   289 VWRLLG------MSAGV-----CGIT--------------------ALVGQLDCFLMTSGPRGVV 322

  Fly   490 YTDYSAAFYTYDVLLVISTMSVLMMPLGEKLPADNVFRDLWNLLKM-------PHVIAFICFLFV 547
            :      ||.|.   |:||:: |::.:...:|....:...:..:|.       ||:|.......:
Human   323 H------FYGYS---VVSTLA-LLVSIAFPIPICQQWEPSYKRVKALSIVGGDPHLILLASTTVL 377

  Fly   548 LGNFWGFIESFLFLYLKELGAPNYLLGITITVGTVSSI---PFLYGAEKITRIFGHVNLIIIAFF 609
            :|.....:::|||.::|:.|:...::|.::.:..:..|   ||   ...:.|......|:.:...
Human   378 VGAIVSTVQNFLFWHMKDHGSGELVMGFSVALSLLGEILLHPF---KATLLRKLSRTGLVGLGLS 439

  Fly   610 SHAGRLVGYSFIETAWWCFPFEAMESLSCH-LMWVAAATYCSILAPKSLLATLIGVLGMAHF-SL 672
            ..||:|:.|||:.:.|...|.:.:.::|.. |.|...|:...:..|:  :...:..|...|| ..
Human   440 CLAGQLLYYSFLWSWWSVLPIQILSAISNRALWWAVGASVEDLATPR--MERALSALFRGHFYGS 502

  Fly   673 GRGSGSFTGGLLIGQFGTRDAFRYMGLLAVVGGIAYGLLHLIWL-------RKFDHTTEESEEEV 730
            |...|||.||.::.:|..  |..|......:         |:||       |:.....:....::
Human   503 GCSLGSFVGGFVVMRFSL--AVLYQACCVAL---------LLWLALLLSIQRRLPRERKIKYSKL 556

  Fly   731 EAVEAGETEKLTEPATKEQGT 751
            .::|..:|      :..||||
Human   557 LSMEVSDT------SDSEQGT 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31663	NP_001259884.1	MFS_1_like	36..111	CDD:289593	12/56 (21%)
		MFS	<423..711	CDD:119392	61/299 (20%)
		MFS_1	<423..678	CDD:284993	53/266 (20%)
MFSD6L	NP_689812.3	MFS	<28..87	CDD:304372	12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..160		10/66 (15%)
		MFS	368..>529	CDD:119392	38/167 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910