Protein Alignment nis and C16orf96

DIOPT Version :10

• Sequence 1: NP_608605.1
• Gene: nis / 33337
• FlyBaseID: FBgn0031347
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_001138483.1
• Gene: C16orf96 / 342346
• HGNCID: 40031
• Length: 1141
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 163/911 - (17%)
• Similarity: 283/911 - (31%)
• Gaps: 377/911 - (41%)

  Fly    22 NFYALHVLLTCFAQRLEVLDEVVEQ----------EDYMVAN----------VRLQSSLLTLGNT 66
            :.:||.|.:|...:.:::|..::::          ||:.:.|          ..||:...|:..|
Human   151 DLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKT 215

  Fly    67 SKFRLFAGA-DA----------------------------------------------------- 77
            ....|::|. ||
Human   216 EDMVLWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTV 280

  Fly    78 ---------EEGAAAEPAAEPPAEEAEAPPA--PVEEPP-AADPAPEPAPEPAPEPAAE-----E 125
                     .||::|:..:...|:|...|||  |...|. ..:.||.|||...|.|..|     |
Human   281 WHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELE 345

  Fly   126 PAPA-EPVPEEA-------APAEAAAPSPEPVGSNHEP------TPSATPAPEEHP--------- 167
            |.|| .|||..:       ||.....|.|.| |:...|      .|...|.|:..|
Human   346 PVPALGPVPGPSVTPGSLPAPWPVLGPVPAP-GAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWD 409

  Fly   168 -----PSEPEADTSKAPMDVPA---------------------------EAKGEE---LAPQASR 197
                 |::|:  .|:||  .||                           :.||||   .:.:..|
Human   410 LGVLRPTQPQ--PSRAP--PPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLR 470

  Fly   198 VSSRSSGRDKSHSQTDGSLTNNLLRLER---------RLSKIELQKEQATMEVQ----------- 242
            ..:|..|..|..::.||      :..:|         |..|.::.|::...:|.
Human   471 ERARKDGAPKDRTRKDG------VPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVP 529

  Fly   243 --------------------------------------------------QFVSNLTSQLKITME 257
                                                              ...|:.....|:..:
Human   530 KDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAK 594

  Fly   258 QVNN-----MTHLLIDRK-------------PNPQRFRLLRHIAKQLRVLMVTTGDE------VS 298
            .|.:     |..:..|..             ..|.|.      |.:.::|    ||:      :|
Human   595 FVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRG------ATESQIL----GDDSEIYEILS 649

  Fly   299 VSWSSGDIVDGVEEEGLSEEEVPVESSAPTEVEK-------------PEEEEELE---------L 341
            .|:|:..|   ..:..||:..|..:.:...|.:|             |.:.:.|:         |
Human   650 PSYSAASI---GPDPALSQAMVATKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNL 711

  Fly   342 EQPLCY-----SPEKMLTELLDLKSQFCALTNKVNELAAALLKQDS-QRL----MDQMKDLSETV 396
            .|.|.|     .|..:.| .:|:      |..|:..|..:.||::. :|:    ::.|||
Human   712 NQRLSYLANMGGPSSLGT-TVDI------LQKKIGSLQKSRLKEEELERIWGNQIEMMKD----- 764

  Fly   397 RDIKLYMASNKEATNGMMTRLNDCVYQIQVLKKSASHLDEVKIDKTEVELLLAEKVDFQQLATKV 461
                .|:..:| |...:..|::    :.:.|:.....|:..|::|:.:|..|.||.|...||.|.
Human   765 ----RYITLDK-AVENLQIRMD----EFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKA 820

  Fly   462 SLEQLEEYKARLEQMFCEVRHIVSLNEKNVLQIIDNLRMTLGIDALELSLKDFREMIERRVQIIA 526
            |...||.....|.:|...:...|:::|.:..:.::.|...:....:...|...::.:|...:|:.
Human   821 SRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVR 885

  Fly   527 EALQKYMEMTNDDCAAAAGRVKVMQDLACLACDTTCVMRTVERSKVPSLPNAKGSTGLGPIVTYE 591
            :.|.:.:.:..|  :||..|.|:.:.:.|::||....|.|                  ||    :
Human   886 KLLIEGLRLDPD--SAAGFRRKLFKRVKCISCDRPVEMMT------------------GP----Q 926

  Fly   592 LGQIRKSGIMGYYRKDEFPHSTSA-----------------------------WTKGASGVPMVK 627
            |..|||:.::...|    |.|.::                             |..|......:|
Human   927 LITIRKAHLLSRLR----PASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLK 987

  Fly   628 C 628
            |
Human   988 C 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nis	NP_608605.1	DUF4795	379..562	CDD:464990	41/187 (22%)
C16orf96	NP_001138483.1	RRM_SF	<248..284	CDD:473069	0/35 (0%)
		PHA03247	<286..436	CDD:223021	43/154 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..339		14/42 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..439		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..561		15/111 (14%)
		penta_MxKDx	<501..552	CDD:131998	4/50 (8%)
		DUF4795	729..919	CDD:464990	47/212 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1105..1141