DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4887 and Rbm5

DIOPT Version :10

Sequence 1:NP_608582.2 Gene:CG4887 / 33304 FlyBaseID:FBgn0031318 Length:1004 Species:Drosophila melanogaster
Sequence 2:NP_001094018.1 Gene:Rbm5 / 300996 RGDID:1305059 Length:815 Species:Rattus norvegicus


Alignment Length:919 Identity:298/919 - (32%)
Similarity:443/919 - (48%) Gaps:158/919 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 SDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDH 195
            ||:.::..|...|...:..||    |||  ...||||.....:.|::  |||     |..|:.|:
  Rat     3 SDKRVSRTERSGRYGSIIDRD----DRD--ERESRSRRRDSDYKRSS--DDR-----RGDRYDDY 54

  Fly   196 RMYNGGGSNHNRDRDRDRDREQDRERD---RDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALN 257
            |.|:      :.:|:|:| |..||..|   .|.|     .|..||..|....|.:|         
  Rat    55 RDYD------SPERERER-RNSDRSEDGYHSDGD-----YGEHDYRHDISDERESK--------- 98

  Fly   258 IIIIFGLTKEMTRADI--MSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQ 320
            .|::.||...:|.:||  |.|..: ..:||.:|::::: |..|||.|||||..:::|..||:..|
  Rat    99 TIMLRGLPITITESDIREMMESFE-GPQPADVRLMKRK-TGVSRGFAFVEFYHLQDATSWMEANQ 161

  Fly   321 GVLKLNDERVSMRYSHKR--IQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSG-SEGVDEV 382
            ..|.:..:.::|.||:.|  .:||.||||.:.||:.|..||.|...:.|||.....| :|.|..|
  Rat   162 KKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSV 226

  Fly   383 STILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDS 447
            . .....|:|||:...|..::::|||..:   .|..|:.:.:.:|..||.:||..::...:.:|:
  Rat   227 D-YYCDTIILRNIAPHTVVDSIMTALSPY---ASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDA 287

  Fly   448 MNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGNISAV------SP 506
            ..:...|.:|.|||.:|.:.:.:.:.....:...||...:   |...:|.|..|:|.      |.
  Rat   288 SQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNR---VSAFSVASTAIAAAQWSSTQSQ 349

  Fly   507 SGLGGNYTLADVPRLAEYSASLYASNPAEHAY--YVQY---YTEYYTADINKNNRDSHLTEANSG 566
            ||.|||         .:||    ...|.:..|  |.||   |.::|.........|:   .|.||
  Rat   350 SGEGGN---------VDYS----YMQPGQDGYTQYTQYSQDYQQFYQQQTGGLESDA---SATSG 398

  Fly   567 AAVAL--SAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKG-NDGKIYPTPDVT 628
            ..|..  :|:..:..::.:..:....:.|..||.:.   :|.....|::|.| ..|..|..||.:
  Rat   399 TTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPST---STSTQAPAASPTGVVPGTKYAVPDTS 460

  Fly   629 QYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLADAE 693
            .|||||:||||||.||||||:.:||||||:.|..|||||..:.|||.|..:|:.          :
  Rat   461 TYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSN----------Q 515

  Fly   694 QKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILANEVATTSRG 758
            |.|...:|:.|||:   :..|.|.|::|.||||:|||.||::|: ....:.||:  |.:....| 
  Rat   516 QAGLPSTKEGKEKK---EKPKSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPV--NSLREEER- 573

  Fly   759 NQGGYADVGFSILEKK----ERGKL------NDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQ 813
            .:...||.||::.|||    ||.:|      |....||.   ...||.||.|.||:||:.....:
  Rat   574 RESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPL---KRGLVAAYSGDSDNEEELVERLE 635

  Fly   814 NTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL-----AKLNQN 873
                         :||....|:.|:.||||:|.|.:.:.|.:|.::|.|||:|:     ::|::.
  Rat   636 -------------SEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRSRLSEQ 687

  Fly   874 TSSSI---EEALAYRDRAKERRLKYGESDPPPPNRSRE------RFEQEIKTLQSRQKQSTSATP 929
            ...::   |..:.|||||.|||.|||..:||.|.|.::      .:||..|.             
  Rat   688 ELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKD------------- 739

  Fly   930 AMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNK-SGQMIPGND-YKSY 992
              .|..||:|:::||.|||.||.|||||.||.|..|||..|....|||.| |...:.|.| ||..
  Rat   740 --GIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDA 802

  Fly   993 IKKMMKQRY 1001
            ::|.|..|:
  Rat   803 VRKAMFARF 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4887NP_608582.2 U2AF_lg 93..>193 CDD:273727 19/61 (31%)
RRM_SF 255..335 CDD:473069 26/81 (32%)
ZnF_RBZ 341..364 CDD:197784 12/22 (55%)
RanBP2-type Zn finger 342..361 CDD:275377 10/18 (56%)
RRM1_RRM2_RBM5_like 387..473 CDD:409752 22/85 (26%)
OCRE_RBM5_like 623..678 CDD:293881 35/54 (65%)
OCRE repeat 1 628..635 CDD:293881 4/6 (67%)
OCRE repeat 2 636..643 CDD:293881 6/6 (100%)
OCRE repeat 3 644..651 CDD:293881 5/6 (83%)
OCRE repeat 4 652..659 CDD:293881 6/6 (100%)
OCRE repeat 5 661..668 CDD:293881 4/6 (67%)
G-patch 935..979 CDD:396249 25/43 (58%)
Rbm5NP_001094018.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 35/114 (31%)
RRM1_RBM5 93..179 CDD:410146 30/96 (31%)
zf-RanBP 181..210 CDD:395516 12/28 (43%)
RanBP2-type Zn finger 185..204 CDD:275375 10/18 (56%)
RRM2_RBM5 229..314 CDD:410149 22/87 (25%)
Required for interaction with U2AF2. /evidence=ECO:0000250 321..809 190/557 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..468 17/63 (27%)
Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000250 452..535 44/95 (46%)
OCRE_RBM5 455..510 CDD:293887 35/54 (65%)
OCRE repeat 1 460..467 CDD:293887 4/6 (67%)
OCRE repeat 2 468..475 CDD:293887 6/6 (100%)
OCRE repeat 3 476..483 CDD:293887 5/6 (83%)
OCRE repeat 4 484..491 CDD:293887 6/6 (100%)
OCRE repeat 5 493..500 CDD:293887 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..540 11/44 (25%)
G-patch 743..787 CDD:396249 25/43 (58%)

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