DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tfb4 and Gtf2h3

DIOPT Version :9

Sequence 1:	NP_608574.2	Gene:	Tfb4 / 33294	FlyBaseID:	FBgn0031309	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_001019407.1	Gene:	Gtf2h3 / 288651	RGDID:	1305494	Length:	309	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	139/313 - (44%)
Similarity:	185/313 - (59%)	Gaps:	27/313 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEADQAASKEAESCIDLLVIVLDTNP---SQHFVRQNPQNLTQILEAVIAFGNAHLMQKAQNKLA 62
            |.||       |..::||||::||||   .:..::::...|::.::||:...||||.....|:||
  Rat     1 MAAD-------EDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVLANAHLFMNRSNQLA 58

  Fly    63 VVSCSHHATNFLYP----------------LPRRQVELRQVDGQYEAFNLVEKTVKQQLGSILMN 111
            |::.....:.||||                ||..... ...||:||......:.:.:::..::..
  Rat    59 VIASHIQESRFLYPGKNGRLGDFFGDPGNALPDCNPS-GSKDGKYELLTAANEVIAEEIKDLMTK 122

  Fly   112 APRLSAPCESLLAGSMSMALCYISRLQRNLAPGVKMHSRILVVTGSNECASQYMTFMNVFFTAQK 176
            :.......|:|||||::.|||||.|..:.:....:|.|||||:..:.:.|.|||.||||.|.|||
  Rat   123 SDIKGQHTETLLAGSLAKALCYIHRASKAVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQK 187

  Fly   177 LGITIDTCALDKTLSLLQQGCDITSGQFLKVTQLDGLLQYLLWVFLPAPQIRHKLVLPPPPKVDY 241
            ..|.||.|.||....||||.||||.|.:|||.|:..|||||||||||....|.:|:||||..|||
  Rat   188 QNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDY 252

  Fly   242 RASCFCHRELIDIGYVCSVCLSVFCKYSPICTTCHTIFKNPGPLPIKGKKKKK 294
            ||:|||||.||:||||||||||:||.:|||||||.|.||...|..:|.||||:
  Rat   253 RAACFCHRSLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKQ 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tfb4	NP_608574.2	Tfb4	15..276	CDD:281798	125/279 (45%)
Gtf2h3	NP_001019407.1	tfb4	7..290	CDD:273181	127/283 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345332
Domainoid	1	1.000	244	1.000	Domainoid score	I2137
eggNOG	1	0.900	-	-		E1_COG5242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1160
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3055
OMA	1	1.010	-	-		QHG56022
OrthoDB	1	1.010	-	-		D1220881at2759
OrthoFinder	1	1.000	-	-		FOG0004351
OrthoInspector	1	1.000	-	-		oto96246
orthoMCL	1	0.900	-	-		OOG6_103072
Panther	1	1.100	-	-	LDO	PTHR12831
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3069
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770