DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GABA-B-R3 and gabbr2

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001137515.1 Gene:gabbr2 / 560267 ZFINID:ZDB-GENE-060503-620 Length:935 Species:Danio rerio


Alignment Length:1027 Identity:307/1027 - (29%)
Similarity:467/1027 - (45%) Gaps:203/1027 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 STSRGPRPDGLSELGAATMAVEHINRKRLLPGYTLELVTN--DTQCDPGVGVDRFFHAIYTQPST 224
            |.|:|..|       |..:|::||...|   .|:..|:|.  ||:||...|:..||.||...|  
Zfish    70 SISQGIEP-------AVQLAIQHIRESR---QYSFSLITKIYDTECDNAKGLRAFFDAICYGP-- 122

  Fly   225 RMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFI 289
            :.:|:.|..|..||..:|:.:..||:||:||.:|:|.|:||:::|.|:|||..|::.|||.:.|:
Zfish   123 KHLMIFGGVCPSVTSIIAESLEGWNLVQLSFAATTPVLADRKKYPNFFRTVPSDNAVNPAVVKFL 187

  Fly   290 RKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGS 354
            ..:.|..|.|.:|:.:..|...|:|..|||.|:|..|.|.:| :.|....:..|::.|.|||||.
Zfish   188 NFYNWSRVGTLTQDVQRFSEVRNDLTNELEKADIQIADTESF-SNDPCVNVKKLKDNDVRIIIGQ 251

  Fly   355 FSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPD-QRTACSNHELQLAVENLIVVSTHNSI 418
            |.:.||.::.|.||.|.|:|:.|.||:.......||.. ..|.|:..:|..|:|..|.|.     
Zfish   252 FDENLAAKVFCCAYNLNMYGSKYQWIIPGWYQGNWWEQANSTNCTTRKLLTAMEGYISVD----- 311

  Fly   419 VGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHL 483
                          |.....||.          .|...|......:..:|.|.::|| .||..|.
Zfish   312 --------------FEPLSAKQI----------KGISGRTPQEYEREYNRERDQKGV-ETSKFHG 351

  Fly   484 FPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGV 548
            |          .||.:|.||..|....|..|..|.......|.....::....|..|.:.:|.||
Zfish   352 F----------AYDGIWVIAKTLTRVMELLRHKERHDMYHNFTVDDREVGKMVLDVMNETNFFGV 406

  Fly   549 SGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVF-KL 612
            :|.|.|...:|:||..|.|.|.|....|..|....|.||......|    ..|..|...|.| :|
Zfish   407 TGQVMFRNGERMGTIKFTQFQEGQEVKVGEYNAIADVLDLINNTIR----FQGVEPPKDRTFVRL 467

  Fly   613 RVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILL 677
            :...|....:..::|::.:|:.:..|||.||:..|..:.||:|||.::|:..:|.:..||::.|.
Zfish   468 QRRQINVPLYSILSTITILGMLMGGAFLFFNIKNRNHRLIKMSSPYMNNLIILGGMLSYASIFLF 532

  Fly   678 GLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI 742
            |||.|.:...|  |.|:||.|.::|..|::.|||:|||||:|||.||...  ..|.|:::|.:|.
Zfish   533 GLDGSFVSDKE--FETLCTVRTWILIVGYTTAFGAMFAKTWRVHAIFKNV--KMKKKIIKDQKLF 593

  Fly   743 LLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAY 807
            ::|||:||:|..::..|.:.||::|.:...:||.....|.:..:|.:|.|.:.|...||.::|||
Zfish   594 IIVGGMLLIDLCILICWQIVDPLKRTVEEYSLEADPQGRDIAIRPFLEHCENTHMTIWLGIVYAY 658

  Fly   808 KGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALI 872
            ||||::.|.::|||||:|.|||||||:|||:|||:|.|...|...::.|..::..:.|..:..:|
Zfish   659 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVI 723

  Fly   873 LTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKK 937
            :..:|.||||:|:||.                    :...|........|.|::   .||:  ||
Zfish   724 IFCSTITLCLVFVPKF--------------------VTMRTNPDAATQNRRLKF---TQNQ--KK 763

  Fly   938 EIQALDAEIRKLERLLESGLTTTSTTT--SSSTSLLTG----GGHLKPELT--------VTSGIS 988
            |    |::            |:||.|:  .::||.|.|    ...|:.::|        ||..:.
Zfish   764 E----DSK------------TSTSVTSVNQANTSRLDGLQSDNHRLRMKITELDKELEEVTMQLQ 812

  Fly   989 QTPAASKNRTPSISGIL---PNLLLSV------------LPPVI---PRASWPSAEYMQIPMRRS 1035
            .||    .:||.|....   .|.:||:            |...:   |:|.|.||:..:|     
Zfish   813 DTP----EKTPYIKQNHYQDANNILSIRNFTDGKDGEKSLKNHLEQKPQAQWGSADPSRI----- 868

  Fly  1036 VTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQKGLK 1100
                |:..||:...|  :.|..||:.|...                                 |.
Zfish   869 ----SRGPLEDINSP--EHIQRRLSLQLPI---------------------------------LH 894

  Fly  1101 AAFKSHMGLFTRLIPSSQTASCNAIYNNPNQDSIPSEASSHPNGNHLKPIHR 1152
            .|:...:|        ...|||::..::|         ||.|...|:.|.:|
Zfish   895 HAYLPSIG--------GVDASCSSPTSSP---------SSSPRHRHMPPSYR 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 137/440 (31%)
7tmC_GABA-B-like 621..892 CDD:320175 107/270 (40%)
TM helix 1 621..645 CDD:320175 7/23 (30%)
TM helix 2 657..678 CDD:320175 6/20 (30%)
TM helix 3 696..720 CDD:320175 12/23 (52%)
TM helix 4 741..761 CDD:320175 8/19 (42%)
TM helix 5 797..823 CDD:320175 13/25 (52%)
TM helix 6 832..855 CDD:320175 11/22 (50%)
TM helix 7 862..887 CDD:320175 8/24 (33%)
gabbr2NP_001137515.1 PBP1_GABAb_receptor 56..455 CDD:380589 137/441 (31%)
7tmC_GABA-B-R2 475..744 CDD:320421 107/292 (37%)
TM helix 1 475..500 CDD:320421 7/24 (29%)
TM helix 2 512..533 CDD:320421 6/20 (30%)
TM helix 3 549..573 CDD:320421 12/23 (52%)
TM helix 4 592..612 CDD:320421 8/19 (42%)
TM helix 5 648..674 CDD:320421 13/25 (52%)
TM helix 6 683..706 CDD:320421 11/22 (50%)
TM helix 7 713..738 CDD:320421 8/24 (33%)
GBR2_CC 774..812 CDD:465774 8/37 (22%)

Return to query results.
Submit another query.