Protein Alignment GABA-B-R3 and Gabbr1

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_062312.3
• Gene: Gabbr1 / 54393
• MGIID: 1860139
• Length: 960
• Species: Mus musculus
• Alignment Length: 871
• Identity: 260/871 - (29%)
• Similarity: 417/871 - (47%)
• Gaps: 97/871 - (11%)

  Fly   100 RLNSHSNLPGSTNASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLG-LFELST 163
            |.:...:|.||:.:..:....:.|  :.:.:||:...||||            .|.:| ||.:|
Mouse   129 RCDPDFHLVGSSRSICSQGQWSTP--KPHCQVNRTPHSERR------------AVYIGALFPMS- 178

  Fly   164 SRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMV 227
              |..|.|.:...|..||:|.:|.:| :||.|.|:|:.:|::||||......:..:|..| .:::
Mouse   179 --GGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDP-IKII 240

  Fly   228 MLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKF 292
            ::.|  ||.|:..:|:....||::.:|:||:|||||:|:.||.|:||....:.|||.|:....|:
Mouse   241 LMPG--CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKW 303

  Fly   293 GWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLL---LLRETDTRIIIGS 354
            ||..:.|..|..||.:..:::|...::.|.|.    |||..:.|.:..:   .|:..|.|||:|.
Mouse   304 GWKKIATIQQTTEVFTSTLDDLEERVKEAGIE----ITFRQSFFSDPAVPVKNLKRQDARIIVGL 364

  Fly   355 FSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWP--DQRTACSNHELQLAVENLIVVSTHNS 417
            |.:..|.::.||.|:.|:||..|.|.|.......|:.  |....|:..|:..|||..|.......
Mouse   365 FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVML 429

  Fly   418 IVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGH 482
            ...|..|.|.:.:..|..:|.|:                           .:|.....||
Mouse   430 NPANTRSISNMTSQEFVEKLTKR---------------------------LKRHPEETGG----- 462

  Fly   483 LFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLG 547
                  .|.||..|||:||:||||........|:  ..:|:.|:|....:..:..:.|....|.|
Mouse   463 ------FQEAPLAYDAIWALALALNKTSGGGGRS--GVRLEDFNYNNQTITDQIYRAMNSSSFEG 519

  Fly   548 VSGPVSF--SGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVF 610
            |||.|.|  || .|:..|...|:|.|..:.:..|....|.|.:    .:..||..|..|..:.:.
Mouse   520 VSGHVVFDASG-SRMAWTLIEQLQGGSYKKIGYYDSTKDDLSW----SKTDKWIGGSPPADQTLV 579

  Fly   611 KLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVI 675
            ......::...|.:::.|||:||.||:..|:||::...::.|:.|.|.|:|:|||||....|.|.
Mouse   580 IKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVF 644

  Fly   676 LLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD------K 734
            .||||...:  ....|..||.||::||..||||.:||||.|.:.||.:||:     |:      |
Mouse   645 PLGLDGYHI--GRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTK-----KEEKKEWRK 702

  Fly   735 MLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQT 799
            .|:..:|...||.|:.:|.|.:.:|.:.||:.|.:.....|....|..|...||:|.|.|:...|
Mouse   703 TLEPWKLYATVGLLVGMDILTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNT 767

  Fly   800 WLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLA 864
            ||.:.|.||||||::|:::|:||:.|....:||.:.:|:::|:|.:...|...:..::|.:...|
Mouse   768 WLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAA 832

  Fly   865 FITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVE 929
            |...:..|:.|:..||.:||:||:..:..|.:.......:|......|      ::..|....:|
Mouse   833 FAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTN------NNEEEKSRLLE 891

  Fly   930 VQNRVYKKEIQALDAEIRKLERLLES 955
            .:||..:|.|...:..:.:|...|:|
Mouse   892 KENRELEKIIAEKEERVSELRHQLQS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	134/452 (30%)
		7tmC_GABA-B-like	621..892	CDD:320175	100/276 (36%)
		TM helix 1	621..645	CDD:320175	11/23 (48%)
		TM helix 2	657..678	CDD:320175	10/20 (50%)
		TM helix 3	696..720	CDD:320175	13/23 (57%)
		TM helix 4	741..761	CDD:320175	7/19 (37%)
		TM helix 5	797..823	CDD:320175	13/25 (52%)
		TM helix 6	832..855	CDD:320175	5/22 (23%)
		TM helix 7	862..887	CDD:320175	8/24 (33%)
Gabbr1	NP_062312.3	Sushi	106..156	CDD:459664	5/28 (18%)
		PBP1_GABAb_receptor	170..569	CDD:380589	134/453 (30%)
		7tmC_GABA-B-R1	589..861	CDD:320418	100/278 (36%)
		TM helix 1	589..614	CDD:320418	11/24 (46%)
		TM helix 2	626..647	CDD:320418	10/20 (50%)
		TM helix 3	663..687	CDD:320418	13/23 (57%)
		TM helix 4	709..729	CDD:320418	7/19 (37%)
		TM helix 5	765..791	CDD:320418	13/25 (52%)
		TM helix 6	800..823	CDD:320418	5/22 (23%)
		TM helix 7	830..855	CDD:320418	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..891		3/30 (10%)
		Interaction with ATF4. /evidence=ECO:0000250	887..915		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..960		3/10 (30%)