DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Gpr156

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_695207.2	Gene:	Gpr156 / 260430	RGDID:	708438	Length:	792	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	177/783 - (22%)
Similarity:	299/783 - (38%)	Gaps:	144/783 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 VATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLG 678
            ::.::|.....|.|..|.|:.|.:.||||.:..||.:.:|:|||.|:.:|.:|....|::..|.|
  Rat    42 ISPLSPALLGVIWTFLSCGLLLVLFFLAFTIRCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFG 106

  Fly   679 LDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDK--MLQDIQL 741
            :..:.:.|   |...:...|:.||..|.:|.||.:..|::|::::||:.   ..||  :::|:||
  Rat   107 IQDALVGS---SVEALIQTRLSLLCIGTTLVFGPILGKSWRLYKVFTQR---VPDKRVIIKDLQL 165

  Fly   742 ILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQ-PQVEVCRSQHTQTWLSVLY 805
            :.||..|::.|.:|:..||:|||:: .|..|.:.:..|.|.|... .....|.|:::..|::::.
  Rat   166 LGLVAALVVADVILLVTWVLTDPIQ-CLQILGVSMKVTGRDVSCSLTNTHFCASRYSDVWIALVL 229

  Fly   806 AYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITA 870
            ..|||||:.|.|:|..|.||..|.:|.|..|.|.|..:::|:.::.|:...:.....|.|...:.
  Rat   230 GCKGLLLLYGAYLAGLTNHVSSPPVNQSLTIMVGVNLLLLTAGLLFVVTRYLHSWPNLVFGLTSG 294

  Fly   871 LILTSTTATLCLLFIPKLHDIWA---RNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQN 932
            .|...||...|.:|:|:|....|   .|..|..:........:....:|..|....|:.......
  Rat   295 GIFVCTTTVNCCVFLPQLRQRKAFEGENQTIRHMAKYFSTPSKTFRSKFDEDQSCHLRDEKSCME 359

  Fly   933 RVYKKE---IQALDAEI----RKLERLL-------------------------------ESGLTT 959
            |:..::   |::|..::    .||.:|:                               |||...
  Rat   360 RLLTEKNAVIESLQEQVSNAKEKLVKLMSAECALDSPEWAVPAAASAGGPAECPATSEKESGAAA 424

  Fly   960 TSTTTSSSTSL-LTGGGHLKPELT-----------------VTSGISQTPAASKNRTPS------ 1000
            ..:..:|:.|. :.|.|..:.:.:                 :..|.||.|.|.::..|.
  Rat   425 EDSLPASAASQHMQGPGASRRDASPSPDQKYDMPLKQFCDHLDMGCSQKPKAEQSEGPERGNQEP 489

  Fly  1001 --------ISGIL-----PNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLEEACLPAQ 1052
                    ..|:.     |.....|||..:||.|....|.:| .:.:.:...::..|.....|.|
  Rat   490 MAPGQSLMTDGVACEPHRPRQNSEVLPERLPRVSSVVREKLQ-EVLQELDLGTEAPLSPLPCPQQ 553

  Fly  1053 D-LINLRLAHQQATEAKTGL---INRLRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMGLFTRL 1113
            . ..|...:.|:.:.:|.|.   :.|.|....|..|...||.......:.......|..||..:.
  Rat   554 PWKSNTSGSPQKLSPSKLGFSPYVVRRRRAAQRARSRIPGSVGLKMGHQANNTVSGSQNGLIVQN 618

  Fly  1114 IPSSQTASCNAIYNNPNQDSIPSEASSHPNGNHLKPIHRGSLTKSGTHLDHLTKDPN-------- 1170
            ..|.:....||....|...|:.....|.|:.      .||||..|    .....:|.
  Rat   619 RDSPRLDHHNARSKEPRSSSVKPSPISAPHQ------RRGSLEGS----KQCETEPQEARGYSVA 673

  Fly  1171 FLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPSNRRPSVVQQP--PSLR-------ERVRGSP 1226
            |...|:.|...|...      ...|.:..  .||..|:|..:..|  |||.       .....|.
  Rat   674 FPRQPSASAPAQSST------APCLSSSP--ALPRQRQPLPLLSPGCPSLSSGCYNLDSESSSSD 730

  Fly  1227 RFPHRILPPTCSL---SALAESEDRPGDSTSILGSCKSIPRISLQQATSGGTWKSMETAGKSRLS 1288
            .|..|...|.|.:   |:|..::....||             .|:|.:...:|:.:....|..::
  Rat   731 EFFCRCHRPYCEICFQSSLDSNDSDTSDS-------------DLEQTSGLASWEKLLARSKPVVN 782

  Fly  1289 LGD 1291
            ..|
  Rat   783 FKD 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361
		ANF_receptor	174..568	CDD:279440
		7tm_3	633..889	CDD:278433	80/258 (31%)
Gpr156	NP_695207.2	7tmC_GPR156	48..317	CDD:320419	85/275 (31%)
		TM helix 1	49..73	CDD:320419	9/23 (39%)
		TM helix 2	85..106	CDD:320419	6/20 (30%)
		TM helix 3	121..143	CDD:320419	8/21 (38%)
		TM helix 4	167..183	CDD:320419	5/15 (33%)
		TM helix 5	221..244	CDD:320419	8/22 (36%)
		TM helix 6	253..275	CDD:320419	6/21 (29%)
		TM helix 7	286..311	CDD:320419	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..516		16/108 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..705		37/190 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810