Protein Alignment: GABA-B-R3 and GABBR1

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_005249039.1
• Gene: GABBR1
• HGNCID: 4070
• Length: 966
• Species: Homo sapiens
• Alignment Length: 871
• Identity: 260/872 (30%)
• Similarity: 418/872 (48%)
• Gaps: 97/872 (11%)

  Fly   100 RLNSHSNLPGSTNASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLG-LFELST 163
            |.:...:|.||:.:..:....:.|  :.:.:||:...||||            .|.:| ||.:|
Human   135 RCDPDFHLVGSSRSICSQGQWSTP--KPHCQVNRTPHSERR------------AVYIGALFPMS- 184

  Fly   164 SRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMV 227
              |..|.|.:...|..||:|.:|.:| :||.|.|:|:.:|::||||......:..:|..| .:::
Human   185 --GGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDP-IKII 246

  Fly   228 MLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKF 292
            ::.|  ||.|:..:|:....||::.:|:||:|||||:|:.||.|:||....:.|||.|:....|:
Human   247 LMPG--CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKW 309

  Fly   293 GWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLL---LLRETDTRIIIGS 354
            ||..:.|..|..||.:..:::|...::.|.|.    |||..:.|.:..:   .|:..|.|||:|.
Human   310 GWKKIATIQQTTEVFTSTLDDLEERVKEAGIE----ITFRQSFFSDPAVPVKNLKRQDARIIVGL 370

  Fly   355 FSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWP--DQRTACSNHELQLAVENLIVVSTHNS 417
            |.:..|.::.||.|:.|:||..|.|.|.......|:.  |....|:..|:..|||..|.......
Human   371 FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML 435

  Fly   418 IVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGH 482
            ...|..|.|.:.:..|..:|.|:                           .:|.....||
Human   436 NPANTRSISNMTSQEFVEKLTKR---------------------------LKRHPEETGG----- 468

  Fly   483 LFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLG 547
                  .|.||..|||:||:||||........|:  ..:|:.|:|....:..:..:.|....|.|
Human   469 ------FQEAPLAYDAIWALALALNKTSGGGGRS--GVRLEDFNYNNQTITDQIYRAMNSSSFEG 525

  Fly   548 VSGPVSF--SGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVF 610
            |||.|.|  || .|:..|...|:|.|..:.:..|....|.|.:    .:..||..|..|..:.:.
Human   526 VSGHVVFDASG-SRMAWTLIEQLQGGSYKKIGYYDSTKDDLSW----SKTDKWIGGSPPADQTLV 585

  Fly   611 KLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVI 675
            ......::...|.:::.|||:||.||:..|:||::...::.|:.|.|.|:|:|||||....|.|.
Human   586 IKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVF 650

  Fly   676 LLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD------K 734
            .||||...:  ..:.|..||.||::||..||||.:||||.|.:.||.:||:     |:      |
Human   651 PLGLDGYHI--GRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTK-----KEEKKEWRK 708

  Fly   735 MLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQT 799
            .|:..:|...||.|:.:|.|.:.:|.:.||:.|.:.....|....|..|...||:|.|.|:...|
Human   709 TLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNT 773

  Fly   800 WLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLA 864
            ||.:.|.||||||::|:::|:||:.|....:||.:.:|:::|:|.:...|...:..::|.:...|
Human   774 WLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAA 838

  Fly   865 FITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVE 929
            |...:..|:.|:..||.:||:||:..:..|.:.......:|......|      ::..|....:|
Human   839 FAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTN------NNEEEKSRLLE 897

  Fly   930 VQNRVYKKEIQALDAEIRKLERLLES 955
            .:||..:|.|...:..:.:|...|:|
Human   898 KENRELEKIIAEKEERVSELRHQLQS 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	132/442 (30%)
		ANF_receptor	174..568	CDD:279440	120/402 (30%)
		7tm_3	633..889	CDD:278433	95/262 (36%)
GABBR1	XP_005249039.1	Sushi	112..162	CDD:278512	5/29 (17%)
		PBP1_GABAb_receptor	176..568	CDD:107361	132/447 (30%)
		ANF_receptor	192..548	CDD:279440	120/404 (30%)
		7tm_3	608..862	CDD:278433	95/261 (36%)
		Ax_dynein_light	<890..932	CDD:287215	9/35 (26%)
		cNMPbd_u2	<927..>951	CDD:293249

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910