Protein Alignment GABA-B-R3 and Gabbr2

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001074610.1
• Gene: Gabbr2 / 242425
• MGIID: 2386030
• Length: 940
• Species: Mus musculus
• Alignment Length: 953
• Identity: 284/953 - (29%)
• Similarity: 447/953 - (46%)
• Gaps: 160/953 - (16%)

  Fly   155 LLGLFELSTSRGPRPDGLSELGAATMAVEHINRKRLLPGYTLELVTNDTQCDPGVGVDRFFHAIY 219
            ::||..|:........|...|.|..:|:|.|..:.||..|.|:|...||:||...|:..|:.||.
Mouse    57 IMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIK 121

  Fly   220 TQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPA 284
            ..|:  .:|:.|..|..||..:|:.:..||:||:||.:|:|.|:|::::|||:|||..|::.|||
Mouse   122 YGPN--HLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPA 184

  Fly   285 RIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFA---ATDFKEQLLLLRET 346
            .:..::.|.|..|.|.:|:.:..|...|:|...|...:|..:.|.:|:   .|..|:    |:..
Mouse   185 ILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKK----LKGN 245

  Fly   347 DTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPD-----QRTACSNHELQLAV 406
            |.|||:|.|.|.:|.::.|.|:...|||:.|.||:.......||..     ..:.|....|..|:
Mouse   246 DVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAM 310

  Fly   407 ENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRR 471
            |..|           .|.:..|::....:...|...|:..:      |.|              :
Mouse   311 EGYI-----------GVDFEPLSSKQIKTISGKTPQQYERE------YNS--------------K 344

  Fly   472 RRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEF 536
            |.|||        |.....||   ||.:|.||..|:.|.|....:....::..|:||...:....
Mouse   345 RSGVG--------PSKFHGYA---YDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRII 398

  Fly   537 LQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSG 601
            |..|.:.:|.||:|.|.|...:|:||..|.|.|......|..|....|.|:....   .:::...
Mouse   399 LNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIIND---TIRFQGS 460

  Fly   602 QVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVG 666
            :.|..|.:...::..|:...:..::.|:.:|:.:|.|||.||:..|..|.||:|||.::|:..:|
Mouse   461 EPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILG 525

  Fly   667 CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVF 731
            .:..||::.|.|||.|.:  :|.:|.|:||.|.::|:.|::.|||:|||||:|||.||...  ..
Mouse   526 GMLSYASIFLFGLDGSFV--SEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNV--KM 586

  Fly   732 KDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQH 796
            |.|:::|.:|:::|||:||:|..::..|...||:.|.:...::|.....|.:..:|.:|.|.:.|
Mouse   587 KKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTH 651

  Fly   797 TQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERV 861
            ...||.::|||||||::.|.::|||||:|.|||||||:|||:|||:|.|...|...::.|..::.
Mouse   652 MTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQP 716

  Fly   862 TLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQY 926
            .:.|..:..:|:..:|.||||:|:|||                    :...|........|..|:
Mouse   717 NVQFCIVALVIIFCSTITLCLVFVPKL--------------------ITLRTNPDAATQNRRFQF 761

  Fly   927 RVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTT--SSSTSLLTG----GGHLKPELT--- 982
               .||:  |||    |::            |:||.|:  .:|||.|.|    ...|:.::|
Mouse   762 ---TQNQ--KKE----DSK------------TSTSVTSVNQASTSRLEGLQSENHRLRMKITELD 805

  Fly   983 -----VTSGISQTPAASK-----------------NRTPSISG---ILPNLLLSVLPPVIPRASW 1022
                 ||..:..||..:.                 |.|.|..|   ||.|.|     ...|:..|
Mouse   806 KDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHL-----DQNPQLQW 865

  Fly  1023 PSAEYMQ--------------IPMRRSVTFASQPQLEEACLPA 1051
            .:.|..:              |..|.|:..   |.|..|.||:
Mouse   866 NTTEPSRTCKDPIEDINSPEHIQRRLSLQL---PILHHAYLPS 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	129/451 (29%)
		7tmC_GABA-B-like	621..892	CDD:320175	109/270 (40%)
		TM helix 1	621..645	CDD:320175	8/23 (35%)
		TM helix 2	657..678	CDD:320175	6/20 (30%)
		TM helix 3	696..720	CDD:320175	12/23 (52%)
		TM helix 4	741..761	CDD:320175	8/19 (42%)
		TM helix 5	797..823	CDD:320175	13/25 (52%)
		TM helix 6	832..855	CDD:320175	11/22 (50%)
		TM helix 7	862..887	CDD:320175	8/24 (33%)
Gabbr2	NP_001074610.1	PBP1_GABAb_receptor	57..459	CDD:380589	129/452 (29%)
		7tmC_GABA-B-R2	479..748	CDD:320421	109/292 (37%)
		TM helix 1	479..504	CDD:320421	8/24 (33%)
		TM helix 2	516..537	CDD:320421	6/20 (30%)
		TM helix 3	553..577	CDD:320421	12/23 (52%)
		TM helix 4	596..616	CDD:320421	8/19 (42%)
		TM helix 5	652..678	CDD:320421	13/25 (52%)
		TM helix 6	687..710	CDD:320421	11/22 (50%)
		TM helix 7	717..742	CDD:320421	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..789		14/44 (32%)
		GBR2_CC	778..816	CDD:465774	9/37 (24%)