DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and gbb-1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_741740.3	Gene:	gbb-1 / 189837	WormBaseID:	WBGene00021528	Length:	899	Species:	Caenorhabditis elegans

Alignment Length:	905	Identity:	237/905 - (26%)
Similarity:	401/905 - (44%)	Gaps:	141/905 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 GLFELSTSRGPRPDGLSELGAATMAVEHIN-RKRLLPGYTLELVTNDTQCDPGVGVDRFFHAIYT 220
            |.|.:.:..|....|.:.|.|..||::.:| |..:||||.|.:..:::||.||:.:.:.:..:|
Worm    28 GTFPMESGSGGWAGGEACLPAVEMALKDVNSRLDILPGYVLNMTNHNSQCQPGLAMQQLYDFLY- 91

  Fly   221 QPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPAR 285
            :|.|::::|.|  ||.||..:|:..|.|.:|.:|:|.:|||||:|..||..:||....:..||.|
Worm    92 KPPTKLMLLTG--CSPVTTVIAEAAPVWKLVVLSYGGSSPALSNRNRFPTLFRTHPSANMQNPTR 154

  Fly   286 IAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRI 350
            |..:.||.|...|.....|||......:|........|.......:.  |..:.:..|:..|.||
Worm   155 IHIMEKFKWKRFTILMSVEEVFVTTAKDLEAIARKKGIKVDRQSFYG--DPTDAMKTLQRQDARI 217

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWW---PDQRTACSNHELQLAVENLIVV 412
            |:|.|....|.::||:||...::|..|.|.........|:   |::...|:..::..|.|...
Worm   218 IVGLFYVTEARKVLCQAYHHGLYGRRYVWFFIGWYADTWYIPPPEEHLNCTAEQMTEAAEYHF-- 280

  Fly   413 STHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGG 477
             |..|::.:..:...: :.|...|.:::..|:..:|                       ...|||
Worm   281 -TTESVMLSRDNIPAI-SEMTGMQFQQRLTQYFQKD-----------------------TANVGG 320

  Fly   478 TSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQS--KLDGFDYTRSDMAWEFLQQM 540
                  |||     ||..||||||:|||....     ||...|  :|:.|.|....:|....|.:
Worm   321 ------FPE-----APLAYDAVWALALAFNCT-----RNNLPSHIRLENFTYDNKVIADTLFQCV 369

  Fly   541 GKLHFLGVSGPVSFS-GPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQ-V 603
            ....|.||||.|.|| ..||:..|...|:|.|..:.:..|...:..|::    ....:|.:|: .
Worm   370 KNTSFRGVSGKVMFSDSGDRIARTQIEQMQGGKYKIMGYYDTTSGDLEW----YNKEQWLNGKGP 430

  Fly   604 PIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCI 668
            |....|.|....|::...:|.....:.:|||..:....|.....:...|..|.|:.:||..:||.
Worm   431 PPDSTVIKKHAMTVSNEFYYPTILFAVLGIAACVFIYLFTQKHHERLIIFQSQPECNNILLIGCS 495

  Fly   669 FVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHR----------- 722
            ....::.|:||....:..:|..|..:|.|||.:|..||:.|:||||||.:.|||
Worm   496 LCLFSLFLIGLPSDDISISESLFPLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGATENQQLAS 560

  Fly   723 -----------------IFTRTG--------------------SVFKDKMLQDIQLILLVGGLLL 750
                             |.|..|                    :...::.:...:..::|..|..
Worm   561 RQKDEEENTPWEGIRTLISTMVGRQALMRKSSGQAYGALLEKRNTVLNQPISSSKFYVIVAALTA 625

  Fly   751 VDALLVTLWVVTDPM---ERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLL 812
            ||..:..:||:.||:   |:.....|...|..|..::  |.::.|:|...:.|:.::..:|.|||
Worm   626 VDVFVCFVWVLIDPLHLTEQKFPLFTPADSEEDEMIM--PVLQQCQSNQQEVWIGIIMGFKCLLL 688

  Fly   813 VVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLISERV--TLAFITITALILT 874
            |.|.::::|||::|:..:|||:::|:::|:| |:|.....|:..||..:|  ..|||::|.||.|
Worm   689 VFGTFLSYETRNLKLRFINDSRFVGLAIYNVAVMTLVTAPVVTLLIHGKVDANFAFISLTVLICT 753

  Fly   875 STTATLC-------LLFIPKLHDIWARNDIIDPVIHSM-------GLKMECNTRRFVVDDR---- 921
            ..:..|.       ::.:|...|....|..:.|.:.|.       .||.|..|.:..::::
Worm   754 YISVGLIYGPKIRHIIKVPPSADEIQLNGNVGPGVMSKVDQKRYDMLKKENETLQIQIEEKERKI 818

  Fly   922 RELQYRVEVQNRVYKKEIQALDAEI--RKLERLLESGLT-TTSTTTSSSTSL--LTGGGH 976
            .|.:.|:|...:  ..|.:.::|::  ...:::.:..|| :|:||.:::..|  |..|.|
Worm   819 HECKERLEELTK--NSETEDMNAQLLCENDKQIADENLTYSTATTLTTTIPLIDLQNGNH 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	125/439 (28%)
		ANF_receptor	174..568	CDD:279440	116/400 (29%)
		7tm_3	633..889	CDD:278433	82/316 (26%)
gbb-1	NP_741740.3	PBP1_GABAb_receptor	25..414	CDD:107361	124/433 (29%)
		7tmC_GABA-B-R1	447..770	CDD:320418	83/324 (26%)
		TM helix 1	447..472	CDD:320418	5/24 (21%)
		TM helix 2	484..505	CDD:320418	6/20 (30%)
		TM helix 3	523..547	CDD:320418	13/23 (57%)
		TM helix 4	616..636	CDD:320418	5/19 (26%)
		TM helix 5	673..699	CDD:320418	8/25 (32%)
		TM helix 6	708..731	CDD:320418	8/22 (36%)
		TM helix 7	739..764	CDD:320418	8/24 (33%)
		PRKG1_interact	793..>848	CDD:318172	9/56 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3553
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870