Protein Alignment GABA-B-R3 and gbb-1

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_741740.3
• Gene: gbb-1 / 189837
• WormBaseID: WBGene00021528
• Length: 899
• Species: Caenorhabditis elegans
• Alignment Length: 905
• Identity: 237/905 - (26%)
• Similarity: 401/905 - (44%)
• Gaps: 141/905 - (15%)

  Fly   157 GLFELSTSRGPRPDGLSELGAATMAVEHIN-RKRLLPGYTLELVTNDTQCDPGVGVDRFFHAIYT 220
            |.|.:.:..|....|.:.|.|..||::.:| |..:||||.|.:..:::||.||:.:.:.:..:|
 Worm    28 GTFPMESGSGGWAGGEACLPAVEMALKDVNSRLDILPGYVLNMTNHNSQCQPGLAMQQLYDFLY- 91

  Fly   221 QPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPAR 285
            :|.|::::|.|  ||.||..:|:..|.|.:|.:|:|.:|||||:|..||..:||....:..||.|
 Worm    92 KPPTKLMLLTG--CSPVTTVIAEAAPVWKLVVLSYGGSSPALSNRNRFPTLFRTHPSANMQNPTR 154

  Fly   286 IAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRI 350
            |..:.||.|...|.....|||......:|........|.......:.  |..:.:..|:..|.||
 Worm   155 IHIMEKFKWKRFTILMSVEEVFVTTAKDLEAIARKKGIKVDRQSFYG--DPTDAMKTLQRQDARI 217

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWW---PDQRTACSNHELQLAVENLIVV 412
            |:|.|....|.::||:||...::|..|.|.........|:   |::...|:..::..|.|...
 Worm   218 IVGLFYVTEARKVLCQAYHHGLYGRRYVWFFIGWYADTWYIPPPEEHLNCTAEQMTEAAEYHF-- 280

  Fly   413 STHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGG 477
             |..|::.:..:...: :.|...|.:::..|:..:|                       ...|||
 Worm   281 -TTESVMLSRDNIPAI-SEMTGMQFQQRLTQYFQKD-----------------------TANVGG 320

  Fly   478 TSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQS--KLDGFDYTRSDMAWEFLQQM 540
                  |||     ||..||||||:|||....     ||...|  :|:.|.|....:|....|.:
 Worm   321 ------FPE-----APLAYDAVWALALAFNCT-----RNNLPSHIRLENFTYDNKVIADTLFQCV 369

  Fly   541 GKLHFLGVSGPVSFS-GPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQ-V 603
            ....|.||||.|.|| ..||:..|...|:|.|..:.:..|...:..|::    ....:|.:|: .
 Worm   370 KNTSFRGVSGKVMFSDSGDRIARTQIEQMQGGKYKIMGYYDTTSGDLEW----YNKEQWLNGKGP 430

  Fly   604 PIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCI 668
            |....|.|....|::...:|.....:.:|||..:....|.....:...|..|.|:.:||..:||.
 Worm   431 PPDSTVIKKHAMTVSNEFYYPTILFAVLGIAACVFIYLFTQKHHERLIIFQSQPECNNILLIGCS 495

  Fly   669 FVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHR----------- 722
            ....::.|:||....:..:|..|..:|.|||.:|..||:.|:||||||.:.|||
 Worm   496 LCLFSLFLIGLPSDDISISESLFPLLCHARVTILLFGFTFAYGSMFAKVWIVHRMGATENQQLAS 560

  Fly   723 -----------------IFTRTG--------------------SVFKDKMLQDIQLILLVGGLLL 750
                             |.|..|                    :...::.:...:..::|..|..
 Worm   561 RQKDEEENTPWEGIRTLISTMVGRQALMRKSSGQAYGALLEKRNTVLNQPISSSKFYVIVAALTA 625

  Fly   751 VDALLVTLWVVTDPM---ERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLL 812
            ||..:..:||:.||:   |:.....|...|..|..::  |.::.|:|...:.|:.::..:|.|||
 Worm   626 VDVFVCFVWVLIDPLHLTEQKFPLFTPADSEEDEMIM--PVLQQCQSNQQEVWIGIIMGFKCLLL 688

  Fly   813 VVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLISERV--TLAFITITALILT 874
            |.|.::::|||::|:..:|||:::|:::|:| |:|.....|:..||..:|  ..|||::|.||.|
 Worm   689 VFGTFLSYETRNLKLRFINDSRFVGLAIYNVAVMTLVTAPVVTLLIHGKVDANFAFISLTVLICT 753

  Fly   875 STTATLC-------LLFIPKLHDIWARNDIIDPVIHSM-------GLKMECNTRRFVVDDR---- 921
            ..:..|.       ::.:|...|....|..:.|.:.|.       .||.|..|.:..::::
 Worm   754 YISVGLIYGPKIRHIIKVPPSADEIQLNGNVGPGVMSKVDQKRYDMLKKENETLQIQIEEKERKI 818

  Fly   922 RELQYRVEVQNRVYKKEIQALDAEI--RKLERLLESGLT-TTSTTTSSSTSL--LTGGGH 976
            .|.:.|:|...:  ..|.:.::|::  ...:::.:..|| :|:||.:::..|  |..|.|
 Worm   819 HECKERLEELTK--NSETEDMNAQLLCENDKQIADENLTYSTATTLTTTIPLIDLQNGNH 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	126/449 (28%)
		7tmC_GABA-B-like	621..892	CDD:320175	85/331 (26%)
		TM helix 1	621..645	CDD:320175	5/23 (22%)
		TM helix 2	657..678	CDD:320175	6/20 (30%)
		TM helix 3	696..720	CDD:320175	13/23 (57%)
		TM helix 4	741..761	CDD:320175	5/19 (26%)
		TM helix 5	797..823	CDD:320175	8/25 (32%)
		TM helix 6	832..855	CDD:320175	8/23 (35%)
		TM helix 7	862..887	CDD:320175	8/31 (26%)
gbb-1	NP_741740.3	PBP1_GABAb_receptor	25..426	CDD:380589	126/449 (28%)
		7tmC_GABA-B-R1	447..770	CDD:320418	83/324 (26%)
		TM helix 1	447..472	CDD:320418	5/24 (21%)
		TM helix 2	484..505	CDD:320418	6/20 (30%)
		TM helix 3	523..547	CDD:320418	13/23 (57%)
		TM helix 4	616..636	CDD:320418	5/19 (26%)
		TM helix 5	673..699	CDD:320418	8/25 (32%)
		TM helix 6	708..731	CDD:320418	8/22 (36%)
		TM helix 7	739..764	CDD:320418	8/24 (33%)