DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and Pcdhb12

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_444367.1 Gene:Pcdhb12 / 93883 MGIID:2136747 Length:789 Species:Mus musculus


Alignment Length:877 Identity:247/877 - (28%)
Similarity:392/877 - (44%) Gaps:179/877 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   729 KASSQA---------SSTPIVAVVATD-----PDYGNFG-QVSYRIVAGNEAGIFRIDRSTGEIF 778
            |:.|:|         .|..:||.||.|     .:....| |:.||   ||:. :.::|..||.:|
Mouse    18 KSDSEAIRYSMPEEKESGYLVANVAKDLGLRVEELATRGAQIHYR---GNKE-LLQMDAETGNLF 78

  Fly   779 V---VRPDMLSVRTQP--MHMLNISATDGGNLRSNADAVVF----LSIIDAMQRPPIFEKARYNY 834
            :   :..:.|...|:|  :|...|.          .:.|.|    |.:.|.....|.|.......
Mouse    79 LKEKLDREALCGATEPCVLHFQIIL----------ENPVQFFQTELQLTDINDHSPEFSDTEMLL 133

  Fly   835 YVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGN-------IRIAKPLDH 892
            .:.|:...|||.....|...|:...:...|::   :|:.:|.:.|.|.:       :.:.:.||.
Mouse   134 TIPENAQPGTVFPLKAAHDSDIGSNAVQNYTV---NPNIHFHVVTLSRSDGRKYPELVLDRALDR 195

  Fly   893 EAKSQVLLNIQA-TLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAH 956
            |.:.::.|.:.| ..|.||..|.|:|:|||.|:|||||:|..|:..:.|||::.|.|.:....|.
Mouse   196 EEQPELTLTLTALDGGSPPRSGTTEVHIEVVDINDNAPQFIQSLYEVQVPENSPLNALVVMVSAT 260

  Fly   957 DKDSGSSGQVTYSLVKESGKGL---FAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLST 1018
            |.|:|..|.|.|||.:  |.||   |.||..:|.:.|::.||:|.|..:|:.:.|||||  .||.
Mouse   261 DLDAGIYGNVAYSLFQ--GDGLSQPFVIDKITGEIRLTKELDFEVSHHYTIEIAATDGG--GLSG 321

  Fly  1019 NLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNV 1083
            ..|:::.|.|||||.|.....:.:|.|.|: |....:...:.||.|:|:|.||        |.::
Mouse   322 KCTVVIQVLDVNDNAPELAIRKLTVPVPEN-SAETVVAVFSVSDSDSGDNGRI--------VCSI 377

  Fly  1084 TNSISSSDVSQHFGI---FPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLD 1145
            .|:|.       |.:   |.|...:....|||||:|..|.:|:...|.|||....:..:.|:|.|
Mouse   378 QNNIP-------FLLKPTFENYYTLVTEGPLDRESRAEYNITITVWDLGTPRLTTQHTITVQVAD 435

  Fly  1146 ANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLP-------INSSFQVHP 1203
            .|||.|.|.::.|...::||......:|.::|:|.|.|.||.|.|||||       :.|...::.
Mouse   436 INDNAPAFTQTSYTLFVQENNSPALHIGTISATDSDSGSNAHITYSLLPPHDSQLALASLVSINS 500

  Fly  1204 VTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVRE 1268
            ..|::.....:|.|:.:.::|.|:|.|.|:|..|::..||:.|.|.|||:|.:..|.::..:...
Mouse   501 DNGQLFALRAMDYEMLQAFELHVDATDGGSPALSSQALVRVVVLDDNDNSPFVLYPMQNASAPCT 565

  Fly  1269 E-----QPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEER 1328
            |     ..||..:.:|.|||||.||||.:::.::|..:.   ||||:...:|.:||..:|...:.
Mouse   566 ELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEP---GLFSVWAHNGEVRTTRLLSERDA 627

  Fly  1329 SIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERP 1393
            ..::|.:...|.|:|||.....|.|.|:|                           |...|....
Mouse   628 PKHKLLLLVKDNGDPPRSASVTLHVLVVD---------------------------GFSQPYLPL 665

  Fly  1394 ADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDT 1458
            .:|.|:|.::.: |:...|                      ||||.   ..|.|.|.|.:...  
Mouse   666 PEVARDSTQDDY-DVLTLY----------------------LVVAL---ASVSSLFLLSVLLF-- 702

  Fly  1459 TASNNPQSSAITVKI----EVADVND-NAPE--WPQDPIDLQVSEATPVGTIIHNF---TATDAD 1513
                      :.|::    ..|.:.| :.||  :|...:|  ||.|   ||:..::   ...:..
Mouse   703 ----------VGVRLCRRARAASLGDYSVPEGHFPSHLVD--VSRA---GTLSQSYQYEVCLNGG 752

  Fly  1514 TGTNGDLQYRLIR-YFPQL-----NESQEQAM 1539
            ||||   ::..:: .||.|     .|.:|.|:
Mouse   753 TGTN---EFNFLKPLFPILPTQAAAEERENAV 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637
Cadherin_repeat 616..711 CDD:206637
Cadherin_repeat 719..820 CDD:206637 27/114 (24%)
Cadherin_repeat 832..927 CDD:206637 27/102 (26%)
Cadherin_repeat 937..1032 CDD:206637 39/97 (40%)
Cadherin_repeat 1040..1149 CDD:206637 33/111 (30%)
Cadherin_repeat 1158..1252 CDD:206637 32/100 (32%)
Cadherin_repeat 1263..1361 CDD:206637 32/102 (31%)
Cadherin_repeat 1369..1481 CDD:206637 18/116 (16%)
Cadherin_repeat 1489..1598 CDD:206637 16/60 (27%)
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
CA_like 2171..>2232 CDD:481204
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Pcdhb12NP_444367.1 Cadherin_2 23..105 CDD:462413 22/95 (23%)
Cadherin_repeat 133..231 CDD:206637 27/100 (27%)
Cadherin_repeat 240..335 CDD:206637 39/98 (40%)
Cadherin_repeat 345..439 CDD:206637 33/109 (30%)
Cadherin_repeat 447..549 CDD:206637 32/101 (32%)
Cadherin_repeat 568..656 CDD:206637 30/90 (33%)
Cadherin_C_2 680..762 CDD:465139 25/126 (20%)
Blue background indicates that the domain is not in the aligned region.

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