DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gsc and Pitx1

DIOPT Version :9

Sequence 1:	NP_001137762.2	Gene:	Gsc / 33240	FlyBaseID:	FBgn0010323	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_035227.1	Gene:	Pitx1 / 18740	MGIID:	107374	Length:	315	Species:	Mus musculus

Alignment Length:	237	Identity:	68/237 - (28%)
Similarity:	91/237 - (38%)	Gaps:	75/237 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 IRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQMQAHVS 293
            :||...|.....|..||..         ||.|.:.|       .|....::.|.:...:......
Mouse    17 LRPPPPPPHDMGPSFHLAR---------AADPREPL-------ENSASESSDADLPDKERGGEAK 65

  Fly   294 G---AAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGHGPPPKRKRRHRTIFTEEQLEQL 355
            |   ..||.:|.|.....|                         ...|::||.||.||.:||::|
Mouse    66 GPEDGGAGSAGCGGGAEDP-------------------------AKKKKQRRQRTHFTSQQLQEL 105

  Fly   356 EATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNG 420
            ||||.:..|||:.:||::|:..:|.|.||.||||||||||||::|.:|..|.|          .|
Mouse   106 EATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCK----------GG 160

  Fly   421 TTNSSSGTTSSTGNGSLTVKCPGSDHYSAQLVHIKSDPNGYS 462
            .....||...           |..|.|:|          |||
Mouse   161 YVPQFSGLVQ-----------PYEDVYAA----------GYS 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475	30/52 (58%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		27/127 (21%)
		Homeobox	94..147	CDD:365835	31/52 (60%)
		Interaction with PIT-1	151..280		13/62 (21%)
		Forkhead_N	196..>275	CDD:369872
		OAR	277..294	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940