Protein Alignment Gsc and Pitx1

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_035227.1
• Gene: Pitx1 / 18740
• MGIID: 107374
• Length: 315
• Species: Mus musculus
• Alignment Length: 237
• Identity: 68/237 - (28%)
• Similarity: 91/237 - (38%)
• Gaps: 75/237 - (31%)

  Fly   229 IRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQMQAHVS 293
            :||...|.....|..||..         ||.|.:.|       .|....::.|.:...:......
Mouse    17 LRPPPPPPHDMGPSFHLAR---------AADPREPL-------ENSASESSDADLPDKERGGEAK 65

  Fly   294 G---AAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGHGPPPKRKRRHRTIFTEEQLEQL 355
            |   ..||.:|.|.....|                         ...|::||.||.||.:||::|
Mouse    66 GPEDGGAGSAGCGGGAEDP-------------------------AKKKKQRRQRTHFTSQQLQEL 105

  Fly   356 EATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNG 420
            ||||.:..|||:.:||::|:..:|.|.||.||||||||||||::|.:|..|.|          .|
Mouse   106 EATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCK----------GG 160

  Fly   421 TTNSSSGTTSSTGNGSLTVKCPGSDHYSAQLVHIKSDPNGYS 462
            .....||...           |..|.|:|          |||
Mouse   161 YVPQFSGLVQ-----------PYEDVYAA----------GYS 181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	33/55 (60%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		27/127 (21%)
		Homeodomain	91..147	CDD:459649	33/55 (60%)
		Interaction with PIT-1	151..280		13/62 (21%)
		OAR	277..294	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291