Protein Alignment Polr1B and Polr1b

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_113961.2
• Gene: Polr1b / 83582
• RGDID: 620822
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 1141
• Identity: 523/1141 - (45%)
• Similarity: 731/1141 - (64%)
• Gaps: 57/1141 - (4%)

  Fly    19 PEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKP 83
            |.:...|::....|.:|...|||||:..:..||.: |...||....:...|:||:.:....|:.|
  Rat    22 PSYAVPPEQQKAALQDLTRAHVDSFNYAVLEGLSH-AVQAIPPFEFAFKDERISLTIVDAAISPP 85

  Fly    84 KVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVPIMLRSKACNLG 148
            .||:..| .:...|||.:.|....:|.|..:..:.|:||||.|..|...||.||||::||.|||.
  Rat    86 AVPKGTI-CKELNIYPAECRGRRSTYRGKLTADISWAVNGVPKGIIKQFLGYVPIMVKSKLCNLY 149

  Fly   149 QATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQT 213
            ...|:.:::|.|...|.||.|:|.|.||::|||||.|||.||.:.|..||.||..::..|:.:..
  Rat   150 NLPPQVLIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKSRGLGYTQFGVSIHC 214

  Fly   214 VREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLVQGYESDQYYV 278
            |||:.|:::..:||:.|||....|.:.|.|.::|:...||.|:.::|.:|:..|::|.|.|.::.
  Rat   215 VREEHSAVNMNLHYVENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEEDSFFK 279

  Fly   279 SCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDVTDFILRERVMIHLDTYEDKF 343
            :.|..|||.|..|..:|..|...::|..||.:. .:|:|.|:.:..:|:..:.:.|||.:..|||
  Rat   280 NSVSQMLRIVMEEGCHTQKQVLDYLGERFRVKL-SLPDWYPNAEAAEFLFNQCICIHLKSNTDKF 343

  Fly   344 QLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPD 408
            .|:..|.:|||..|:|:...:|.||.:.||||.||.|:..:|.|::|:|:..::..|.|:....:
  Rat   344 YLLCLMTRKLFALARGECMEDNPDSLVNQEVLTPGQLFLMFLKEKMENWLLSIKIALDKRAQKTN 408

  Fly   409 ALVTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIH 473
            ..:.:..:.:.......:.|..|..|||||:.|:||||.||:|||.::|:.:|.:||:||||.:|
  Rat   409 VSINNENLMKIFSMGTELTRPFEYLLATGNLRSKTGLGFMQDSGLCVVADKLNFIRYLSHFRCVH 473

  Fly   474 RGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKLV--KAIPKHL 536
            ||:.|..||||..|:|||::|||:||||||||.|||||||||..||:.    .|.|  .:||..|
  Rat   474 RGADFAKMRTTTVRKLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEVV----TKFVYTASIPALL 534

  Fly   537 IDMGMMPLSN---RRYLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIF--GTLPQMMEIGF 596
            ..:|:.|:..   |.|  ...|.|.|||..:|.:.:..|.::.|.||..|:.  ..:|..||:..
  Rat   535 CGLGVTPVDAAPCRPY--SDCYPVLLDGVMVGWVDKELAPEVADTLRRFKVLRERRVPPWMEVAL 597

  Fly   597 IPFK-KNGQFPGLYIATGPARMMRPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELA 660
            ||.. |...:|||::.|.|.|::|||.||:..:.|.:||:|||:|.|||...|::...:||.||.
  Rat   598 IPMTGKPSLYPGLFLFTTPCRLVRPVQNLELGKEELVGTMEQLFMNIAIFEDEVFGGVSTHQELF 662

  Fly   661 KTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHY 725
            ....:|.:||.||..|:||||||||||||||||||.|.|.:..::.|||||||||.:||.||..|
  Rat   663 PHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPCMY 727

  Fly   726 DNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKK------SS 784
            |:..:|::.:|||||||||||||||||||||:|||::|||||:||:||::|:.|.:|      |.
  Rat   728 DHYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQGDDSL 792

  Fly   785 YFARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYF-----DGEVATYKVVKMDEKEDCIVESI 844
            .|...|..|.:::.||.||||..|:||.:|.|.|.|.     :|.|..||     .||:|:|::|
  Rat   793 VFGVKPGDPRVMQKLDNDGLPFIGAKLEFGDPYYGYLNLNTGEGFVVYYK-----SKENCVVDNI 852

  Fly   845 RQLGSFDLSPK-KMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNP 908
            :...:...|.| |.|.:|:||||..|||||||||.|||||.|:.:||||:||||||::|||:|||
  Rat   853 KVCSNDTGSGKFKCVCVTVRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNP 917

  Fly   909 HGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSG 973
            |||||||||.|:||:||||.||:||..:|||||.|||||:|::|||:||:|.|||:|||||||||
  Rat   918 HGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSG 982

  Fly   974 VDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALIS 1038
            :.|.|:.||||.|||:||||||||.||:|||:|||.:..|:|||.||...||:||||||||||::
  Rat   983 ISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPIGGRNVQGGIRFGEMERDALLA 1047

  Fly  1039 HGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDT----------CRLC 1093
            ||.:|||.||||:.||::...||.||||:|:||           |...|.:          |.:|
  Rat  1048 HGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL-----------LEKPPPSWSAMRNRKYNCTVC 1101

  Fly  1094 GDNSSVSMIEIPFSFKYLVTELSSVNINARFKLNEI 1129
            |.:.|:..:.:|:.|:|.|.||:::||  :.||:.|
  Rat  1102 GRSDSIDTVSVPYVFRYFVAELAAMNI--KVKLDVI 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	517/1119 (46%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	18/57 (32%)
Polr1b	NP_113961.2	RNA_pol_B_RPB2	38..1133	CDD:238353	518/1121 (46%)
		RNA_pol_Rpb2_2	186..375	CDD:398318	66/189 (35%)
		RNA_pol_Rpa2_4	563..621	CDD:462028	18/57 (32%)