DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpI135 and NRPD2B

DIOPT Version :9

Sequence 1:	NP_476708.1	Gene:	RpI135 / 33210	FlyBaseID:	FBgn0003278	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_188437.2	Gene:	NRPD2B / 821334	AraportID:	AT3G18090	Length:	1055	Species:	Arabidopsis thaliana

Alignment Length:	1148	Identity:	309/1148 - (26%)
Similarity:	496/1148 - (43%)	Gaps:	205/1148 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KISMKVE---SIWIAKPK--------VPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNG 123
            |::.:||   .|.|...|        |.::::||:.::|.
plant    15 KVNAQVEVFKKIVIKHDKFKTGQDEYVEKEILDVKKQDIL------------------------- 54

  Fly   124 VQKTPINMDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEK--IVRMLIMTRR 186
                     :|.:|:|::|..|...: ..:|..|.|....:.||.|||:|.||  |.:..:.|:|
plant    55 ---------IGSIPVMVKSVLCKTSE-KGKENCKKGNCAFDQGGYFVIKGAEKVFIAQEQMCTKR 109

  Fly   187 NHPICVKRSSWKDRGQNFSDLGMLVQTVREDESS-----LSNV--VHYLNNGTAKFMFSHVKRLS 244
               :.:..|.|....::.:.....:..:.|:|.:     :..|  |::|:              :
plant   110 ---LWISNSPWTVSFRSETKRNRFIVRLSENEKAEDYKIMEKVLTVYFLS--------------T 157

  Fly   245 YVPVCLILKCL-------------MDYTDEEIYNRLVQG-YESDQYYVSCVQAMLREVQNENVYT 295
            .:||.|:...|             .|..|..|.|.|:.. :|:|     .|....|...|...|.
plant   158 EIPVWLLFFALGVSSDKEAMDLIAFDGDDASITNSLIASIHEAD-----AVCEAFRCGNNALTYV 217

  Fly   296 HAQCKSFIGNLFRARFPEVPEWQPDDDVTDFILRERVMIHLDTYEDKFQLIVFMIQKLFQCAQGK 360
            ..|.||       .:||      |.:.|.| .||..:...|...:.|.:.:.:|::.|.....||
plant   218 EHQIKS-------TKFP------PAESVDD-CLRLYLFPCLQGLKKKARFLGYMVKCLLSAYAGK 268

  Fly   361 YKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPDAL------VTSAVMTQC 419
            .|.||.||...:.:.|.|.|.::.:...:.....::.|.:||:|:....|      :.::|:|..
plant   269 RKCENRDSFRNKRIELAGELLEREIRVHLAHARRKMTRAMQKQLSGDGDLKPIEHYLDASVITNG 333

  Fly   420 MRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTT 484
            :.:|...|.....|.....:           ||:|......|.::.:...|.. |.....|.:..
plant   334 LNRAFSTGAWSHPFRKMERV-----------SGVVANLGRANPLQTLIDLRRT-RQQVLYTGKVG 386

  Fly   485 EARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKLVKAIPKHLIDMGMMPLSN--- 546
            :||...|..||.:|.:.||||..|||:.:::|...:|.:.    ::::.:.|...||..|.|
plant   387 DARHPHPSHWGRVCFLSTPDGENCGLVKNMSLLGLVSTQG----LESVVEMLFTCGMEELMNDTS 447

  Fly   547 RRYLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEIGFIPFKKNGQFPGLYIA 611
            ....|:  :.|.|:|..:|..  :::|..|.||:..:....||..|||     |::.....:.|.
plant   448 TPLCGK--HKVLLNGDWVGLC--ADSESFVGELKSRRRQSELPLEMEI-----KRDKDDNEVRIF 503

  Fly   612 TGPARMMRP---VWNL-KWKR----------------VEYIGTLEQLYMEIAIDAKEMY--PDFT 654
            |...|::||   |.|| |.|:                :|.||..|:.....|...|::.  |...
plant   504 TDAGRLLRPLLVVENLHKLKQDKPTQYPFKHLLDQGILELIGIEEEEDCTTAWGIKQLLKEPKNY 568

  Fly   655 THLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMG-KQTMGTPCLNWPKQAANKL-YRLQTPGT 717
            ||.||..:..:.....::|..:::...|.:||.|.. :|.:|....| |....:.| .:|..|..
plant   569 THCELDLSFLLGVSCAIVPFANHDHGKRVLYQSQKHCQQAIGFSSTN-PNIRCDTLSQQLFYPQK 632

  Fly   718 PLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKK 782
            |||:.:..:.::.:....|.||||||..:.||:.||::::|||:.|||.......::....:|.|
plant   633 PLFKTLASECLEKEVLFNGQNAIVAVNVHLGYNQEDSIVMNKASLERGMFRSEQIRSYKAEVDTK 697

  Fly   783 SSYFARHPHMPELIK------------HLDTDGLPHPGSKLSYGSPLY--CYFDGEVATYKVVKM 833
            .|  .:...|.||::            .|:.||.|..|:.:|.|..:.  |...|  |.:. :|:
plant   698 DS--EKRKKMDELVQFGKTYSKIGKVDSLEDDGFPFIGANMSTGDIVIGRCTESG--ADHS-IKL 757

  Fly   834 DEKEDCIVESIRQLGSFDLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTES 898
            ...|..||:.: .|.|.| ..|...|::||..|...:||||:|..||||:.......::.|||..
plant   758 KHTERGIVQKV-VLSSND-EGKNFAAVSLRQVRSPCLGDKFSSMHGQKGVLGYLEEQQNFPFTIQ 820

  Fly   899 GLIPDIVFNPHGFPSRMTIAMMIETMAGKG------------AAIHGNVYDATPFRFSEENTAID 951
            |::||||.|||.||||.|...::|....||            ||.......||||    ....:.
plant   821 GIVPDIVINPHAFPSRQTPGQLLEAALSKGIACPIQKKEGSSAAYTKLTRHATPF----STPGVT 881

  Fly   952 YFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQP 1016
            ...:.|...|::.:|.||:|:|..|..|.:.||.|...||||.||..:|.:.|:||.|...|.||
plant   882 EITEQLHRAGFSRWGNERVYNGRSGEMMRSLIFMGPTFYQRLVHMSENKVKFRNTGPVHPLTRQP 946

  Fly  1017 IKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETG 1081
            :..|||.||:||||||||.||:|||:..|.:|||..||.:...:|.||.:    ...:::|..:.
plant   947 VADRKRFGGIRFGEMERDCLIAHGASANLHERLFTLSDSSQMHICRKCKT----YANVIERTPSS 1007

  Fly  1082 GLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARF 1124
            |...:...||:|..:..|..:.:|:..|.|..||.|:.|...|
plant  1008 GRKIRGPYCRVCASSDHVVRVYVPYGAKLLCQELFSMGITLNF 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpI135	NP_476708.1	RpoB	34..1128	CDD:223163	309/1148 (27%)
		RNA_pol_B_RPB2	35..1125	CDD:238353	309/1148 (27%)
		RNA_pol_Rpa2_4	564..614	CDD:284335	13/49 (27%)
NRPD2B	NP_188437.2	PRK08565	1..1046	CDD:236291	307/1142 (27%)
		RNA_pol_B_RPB2	3..1051	CDD:238353	309/1148 (27%)
		RNA_pol_Rpb2_4	456..517	CDD:282431	19/67 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820