Protein Alignment Polr1B and POLR2B

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_000929.1
• Gene: POLR2B / 5431
• HGNCID: 9188
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1234
• Identity: 341/1234 - (27%)
• Similarity: 546/1234 - (44%)
• Gaps: 257/1234 - (20%)

  Fly    40 VDSFDEML------------TVGLDNSAKHMIPNHWLSPAGE-----KISMKVESIWIAKPK--- 84
            :|||||.:            .:.|...|:|        .:||     :..:|.|.|:::||.
Human    44 LDSFDEFIQMSVQRIVEDAPPIDLQAEAQH--------ASGEVEEPPRYLLKFEQIYLSKPTHWE 100

  Fly    85 ---VPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSV---------NGVQKTPINMDLGEVP 137
               .|..::        |.::|..:::||....|.:..:|         ...|||.|    |::|
Human   101 RDGAPSPMM--------PNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFI----GKIP 153

  Fly   138 IMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEK--IVRMLIMTRRNHPICVKRSSWKDR 200
            |||||..|.|...|..::.:..|...:.||.|:|.|:||  |.:..:.|...:....|.|.:...
Human   154 IMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYT 218

  Fly   201 GQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSH--VKRLSY----VPVCLILKCLMDYT 259
            |:..|   .|..:.|...:...:::.....|..|.....  |..|.|    ||:.::.:.|...:
Human   219 GECRS---CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVS 280

  Fly   260 DEEIYNRLVQGYESDQYYVSCVQAMLRE---VQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDD 321
            |.:|...::..:| |...:..|:..|.|   :|.:||     ..:|||:  |...|.|.: :...
Human   281 DRDILEHIIYDFE-DPEMMEMVKPSLDEAFVIQEQNV-----ALNFIGS--RGAKPGVTK-EKRI 336

  Fly   322 DVTDFILRERVMIHLDTYE----DKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQ 382
            .....:|::.::.|:...:    .|...:.:|:.:|...|.|:.::::.|....:.:.|.|.|..
Human   337 KYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLA 401

  Fly   383 KYLSERVESWVSQVRRCLQKKL-TSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIA------ 440
            .......::.:.:||...||.: ...|..:..|:.|:.      :...::..|||||..
Human   402 FLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRI------ISDGLKYSLATGNWGDQKKAH 460

  Fly   441 -SRTGLGLMQNSGLVIMAENINRMRY---MSHFRAIH----RGSYFTTMRTTEARQLLPDAWGFI 497
             :|.|           :::.:||:.:   :||.|.::    |..     :..:.|||....||.:
Human   461 QARAG-----------VSQVLNRLTFASTLSHLRRLNSPIGRDG-----KLAKPRQLHNTLWGMV 509

  Fly   498 CPVHTPDGTPCGLLNHLTLTCEISM--RPDP-----------KLVKAIPKHLIDMGMMPLSNRRY 549
            ||..||:|...||:.:|.|...||:  :|.|           .|.:..|..:.|...
Human   510 CPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATK-------- 566

  Fly   550 LGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEI--GFIPFKKNGQFPGLYIAT 612
                   :|::|..:| ||: :.|::::.||      .|.:.|:|  ..:...::.:...:.|.|
Human   567 -------IFVNGCWVG-IHK-DPEQLMNTLR------KLRRQMDIIVSEVSMIRDIREREIRIYT 616

  Fly   613 GPARMMRPVW-----------------------NLKWKR------VEYIGTLEQLYMEIA----- 643
            ...|:.||:.                       |..|:.      ||||.|||:..:.:|
Human   617 DAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDD 681

  Fly   644 IDAKEM-YPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAAN 707
            :..||: |....||.|:..:..:...|::||.||:||||||.||..||||.||....|:..:...
Human   682 LQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDT 746

  Fly   708 KLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIY 772
            ..:.|..|..||......:.::..:...|.|:|||:.|||||:.||::|:|::|.:||| :.|::
Human   747 LAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGF-FRSVF 810

  Fly   773 KTKFLTLDKKSSY---------------FARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFD 822
            ...:...:.|..:               ..||    .:...||.|||..||.::|         .
Human   811 YRSYKEQESKKGFDQEEVFEKPTRETCQGMRH----AIYDKLDDDGLIAPGVRVS---------G 862

  Fly   823 GEVATYKVVKMDEKEDCIVESIRQLGSFDLSP---------------------KKMVAITLRVPR 866
            .:|...|.|.:.|.||.:..:.|:....|.|.                     .|...|.:|..|
Human   863 DDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVR 927

  Fly   867 PATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAI 931
            ...||||||||.||||.|..:|..||:|||..|:.|||:.|||..||||||..:||.:.||.:|.
Human   928 IPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSAN 992

  Fly   932 HGNVYDATPFRFSEENTAIDY--FGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLR 994
            .|.:.|||||     |.|::.  ...:|...||:..|.|.||:|..||::|:.||.|..:||||:
Human   993 KGEIGDATPF-----NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLK 1052

  Fly   995 HMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTL 1059
            |||.||...|:.|.::....||::||.|.||:||||||||..|:||||..|::|||..||.....
Human  1053 HMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVH 1117

  Fly  1060 VCHKCGSILAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINAR 1123
            ||:.|| |:|          .....:....||.|.:.:.:|::.:|::.|.|..||.|::|..|
Human  1118 VCNLCG-IMA----------IANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPR 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	341/1234 (28%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	12/56 (21%)
POLR2B	NP_000929.1	Ricin_B_lectin	27..1172	CDD:481363	341/1234 (28%)