Protein Alignment Polr1B and Polr2B

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 340/1234 - (27%)
• Similarity: 548/1234 - (44%)
• Gaps: 256/1234 - (20%)

  Fly    40 VDSFDEML------------TVGLDNSAKHMIPNHWLSPAGE-----KISMKVESIWIAKPKVPQ 87
            :|||||.:            .:.|...|:|        .:||     :.|:|.|.|:::||...:
  Fly    45 LDSFDEFIQMSVQRIVEDSPAIELQAEAQH--------TSGEVETPPRFSLKFEQIYLSKPTHWE 101

  Fly    88 DVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMD-----LGEVPIMLRSKACNL 147
            .  |.....:.|.::|..:::||....|.:..:.|.....|:...     :|::||||||..|.|
  Fly   102 K--DGSPSPMMPNEARLRNLTYSAPLYVDITKTKNVEGLDPVETQHQKTFIGKIPIMLRSTYCLL 164

  Fly   148 GQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNF-SDLGMLV 211
            .|.|..::.:..|...:.||.|:|.|:||:   ||...:.....|...|.||....| :::...:
  Fly   165 SQLTDRDLTELNECPLDPGGYFIINGSEKV---LIAQEKMATNTVYVFSMKDGKYAFKTEIRSCL 226

  Fly   212 QTVREDESSLSNVVHYLNNGTAKFMFSHVKR-----LSY----VPVCLILKCLMDYTDEEIYNRL 267
            :......|:|  .|:.:..|:.....|.:.:     |.|    :|:.::.:.|....|.:|...:
  Fly   227 EHSSRPTSTL--WVNMMARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALGFVADRDILEHI 289

  Fly   268 VQGYESDQYYVSCVQAMLRE---VQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDV--TDFI 327
            :..:: |...:..|:..|.|   ||.:||     ..:|||  .|...|.|.:   |..:  ...|
  Fly   290 IYDFD-DPEMMEMVKPSLDEAFVVQEQNV-----ALNFIG--ARGARPGVTK---DKRIKYAKEI 343

  Fly   328 LRERVMIHLDTYE----DKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSER 388
            |::.::.|:...:    .|...:.:|:.:|...:.|:.::::.|....:.:.|.|.|........
  Fly   344 LQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGL 408

  Fly   389 VESWVSQVRRCLQK-----KLTSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIA-------S 441
            .::.:.:||...||     |..:.:..:.:.::|..:|.:          |||||..       :
  Fly   409 FKNLMKEVRMYTQKFIDRGKDFNLELAIKTNIITDGLRYS----------LATGNWGDQKKAHQA 463

  Fly   442 RTGLGLMQNSGLVIMAENINRMRY---MSHFRAIH----RGSYFTTMRTTEARQLLPDAWGFICP 499
            |.|           :::.:||:.:   :||.|.::    |..     :..:.|||....||.:||
  Fly   464 RAG-----------VSQVLNRLTFASTLSHLRRVNSPIGRDG-----KLAKPRQLHNTLWGMLCP 512

  Fly   500 VHTPDGTPCGLLNHLTLTCEISM--RPDP-----------KLVKAIPKHLIDMGMMPLSNRRYLG 551
            ..||:|...||:.:|.|...||:  :|.|           .|.:..|..:.|...
  Fly   513 AETPEGAAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEIAPSAIADATK---------- 567

  Fly   552 EKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEI--GFIPFKKNGQFPGLYIATGP 614
                 :|::|..:| ||: :.|:::..||      .|.:.|:|  ..:...::.:...:.|.|..
  Fly   568 -----IFVNGCWVG-IHR-DPEQLMATLR------KLRRQMDIIVSEVSMIRDIRDREIRIYTDA 619

  Fly   615 ARMMRPVW-----------------------NLKWK------RVEYIGTLEQLYMEIAI---DAK 647
            .|:.||:.                       |..|:      .||||.|||:..:.||:   |.|
  Fly   620 GRICRPLLIVENGSLLLKKTHVEMLKERDYNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLK 684

  Fly   648 E----MYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANK 708
            :    .|....||.|:.....:...|::||.||:||||||.||..||||.||....|:..:....
  Fly   685 QDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTL 749

  Fly   709 LYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYK 773
            .:.|..|..||......:.::..:...|.|:|||::.||||:.||::|:|.:|.|||| :.|::.
  Fly   750 AHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDSVILNASAVERGF-FRSVFY 813

  Fly   774 TKFLTLDKK---------------SSYFARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFDG 823
            ..:...:.|               :....|:.|..:    ||.||:..||.::|         ..
  Fly   814 RSYKDSENKRVGDQEENFEKPHRGTCQGMRNAHYDK----LDDDGIIAPGIRVS---------GD 865

  Fly   824 EVATYKVVKMDEKEDCIVESIRQLGSFDLSP---------------------KKMVAITLRVPRP 867
            :|...|.:.:.|.:|.:..:.::....|.|.                     .|...|.:|..|.
  Fly   866 DVVIGKTITLPENDDELDSNTKRFSKRDASTFLRNSETGIVDQVMLTLNSEGYKFCKIRVRSVRI 930

  Fly   868 ATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIH 932
            ..||||||||.||||.|..:|..||:.||..||.|||:.|||..||||||..:||.:.||..:..
  Fly   931 PQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHAIPSRMTIGHLIECLQGKLGSNK 995

  Fly   933 GNVYDATPFRFSEENTAIDY--FGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRH 995
            |.:.|||||     |.|::.  ....|:..||:..|.|.:|:|..||::.|.:|.|..:||||:|
  Fly   996 GEIGDATPF-----NDAVNVQKISTFLQEYGYHLRGNEVMYNGHTGRKINAQVFLGPTYYQRLKH 1055

  Fly   996 MVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLV 1060
            ||.||...|:.|.|:....||::||.|.||:||||||||..||||||..|::|||..||.....:
  Fly  1056 MVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYRVHI 1120

  Fly  1061 CHKCGSI-LAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINAR 1123
            |:.||.| :|.|     ||.|       ..|:.|.:.:.:|.:.:|::.|.|..||.|:||..|
  Fly  1121 CNFCGLIAIANL-----RNNT-------FECKGCKNKTQISQVRLPYAAKLLFQELMSMNIAPR 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	340/1234 (28%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	12/56 (21%)
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	340/1234 (28%)