Protein Alignment Polr1B and polr1b

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_956812.2
• Gene: polr1b / 325603
• ZFINID: ZDB-GENE-040426-1598
• Length: 1132
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 519/1159 - (44%)
• Similarity: 723/1159 - (62%)
• Gaps: 64/1159 - (5%)

  Fly     2 LEEMQQMKTIPVLTNSRPEFKQIPKKLSR-HLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLS 65
            |.:...:||.|.|.:.......:||:..| .:..|...|::|||:.:|.||....:.:.|..:|.
Zfish     3 LSKWCNLKTEPSLKHLTEAGFGVPKEKQRVPVQELVKAHIESFDQAVTDGLCRVVEAIPPMEFLY 67

  Fly    66 PAGEKISMK-VESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPI 129
             .|::||:. ||:| |..|.|.:..|. |...::|.:.|....:|.......:.||||||.|..|
Zfish    68 -KGDRISLSFVEAI-IHTPSVSKGGIS-RDLRVFPAECRGRRCTYRAKLVADVSWSVNGVPKGII 129

  Fly   130 NMDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKR 194
            ...||::|||::||.|||...:|:|:::|.|...|.||.|::.|.||::|:|||.|||:||.|.|
Zfish   130 KQSLGQMPIMVKSKLCNLHGLSPKELLEHHEEAEEMGGYFIVNGIEKVIRLLIMPRRNYPIAVSR 194

  Fly   195 SSWKDRGQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYT 259
            ..:|.|||.::...:.::.|:|:.::::..:|||:|||....|.:.|.|.::|:...||.|:||:
Zfish   195 PKFKSRGQGYTQYAISMRCVKEEHTAINMNLHYLDNGTVMVNFIYRKELFFLPLGFALKALVDYS 259

  Fly   260 DEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDVT 324
            |.:||..|::|.|.:.:|.|||..|||.|.::...|..:..:::|..||.:. .:|||...:...
Zfish   260 DYQIYQELIKGREDNSFYKSCVSEMLRIVMDQGCTTKIKVLNYLGERFRVKL-NLPEWFTHEQCA 323

  Fly   325 DFILRERVMIHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERV 389
            .|:|.|.:.|||.|..:||.::..|.:|||..|:.:...||.||.|..|||.||.||..:|.|::
Zfish   324 HFLLDECLCIHLKTDVEKFYMLCLMTRKLFSFAKQECMEENPDSPMFHEVLTPGQLYLMFLKEKM 388

  Fly   390 ESWVSQVRRCLQKK------LTSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGLM 448
            |.|:..|:..|:||      || ||:      ||:.......:.:|.|..|||||:.|:||||::
Zfish   389 EGWLVSVKLALEKKPQRVGGLT-PDS------MTKLFNMGTDLTKAFEYLLATGNLMSKTGLGML 446

  Fly   449 QNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNH 513
            |||||.::|:.:|.:||:||||.:|||:.|..||||..|:|||::|||:||||||||.||||:||
Zfish   447 QNSGLCVVADKLNFIRYLSHFRCVHRGAAFAKMRTTTVRKLLPESWGFLCPVHTPDGEPCGLMNH 511

  Fly   514 LTLTCEISMRPDPKLVKAIPKHLIDMGMMPL-SNRRYLGEKLYVVFLDGKHLGHIHQSEAEKIVD 577
            :|..|||.....|  ...:|..|..:|:... .|........|.|.|||..:|.:.:..|..:::
Zfish   512 MTAHCEIVAPVYP--TSTLPGLLCSLGVNAADGNPGQAYSDCYPVILDGAMIGWVEKEVAPSVIE 574

  Fly   578 ELRYGKIFG--TLPQMMEIGFIP-FKKNGQFPGLYIATGPARMMRPVWNLKWKRVEYIGTLEQLY 639
            .||..|:.|  .:|...||..:| ..|...:||||:.|.|.||:|.|.||...:.|.||..||:|
Zfish   575 SLRRFKVLGEKKVPPWTEIVLVPQTGKASLYPGLYLFTTPCRMVRTVRNLSLGKQELIGIFEQVY 639

  Fly   640 MEIAIDAKEMYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQ 704
            :.:.|..||:....|||.||.....:|.:|..||..|:||||||||||||.|||||.|..::..:
Zfish   640 LNVGIFEKEIEDGVTTHQELFPHSMLSVVAEFIPFSDHNQSPRNMYQCQMSKQTMGFPLHSYQYR 704

  Fly   705 AANKLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYG 769
            :.|||||||||.:||.||..||:..:|::.:|||||||||||||||||||||:||:::|||||:|
Zfish   705 SDNKLYRLQTPQSPLVRPAMYDHYDVDNYPIGTNAIVAVISYTGYDMEDAMIVNKSSWERGFAHG 769

  Fly   770 SIYKTKFLTLDKK-----SSYFARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFDGEVATYK 829
            |:|||:.:.|.:|     |..|...|..|:::..||.||||..||.|.||.|.|.|.........
Zfish   770 SVYKTEIIDLSEKVKGDDSIVFGVKPGDPKVMGKLDADGLPFIGSVLKYGDPFYGYISLNTGQSH 834

  Fly   830 VVKMDEKEDCIVESIR------QLGSFDLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQKY 888
            |.....:|.|:|::|:      ..|.|     |.:.:|.||||..|||||||||.|||||.|:.:
Zfish   835 VYFYKYQESCVVDNIKVCSNETGTGRF-----KRICVTSRVPRNPTIGDKFASRHGQKGILSRLW 894

  Fly   889 PAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYF 953
            ||||:||||||:.|||:||||||||||||.|:||:||||.|::||..:|||||.|||||:|:::|
Zfish   895 PAEDMPFTESGMSPDILFNPHGFPSRMTIGMLIESMAGKSASLHGLCHDATPFTFSEENSALEHF 959

  Fly   954 GKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIK 1018
            |::|:|.|||||||||||||:.|.|:.||||.|||:||||||||.||:|||:|||.:..|:||:.
Zfish   960 GELLKAAGYNYYGTERLYSGLSGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPMG 1024

  Fly  1019 GRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGL 1083
            ||...||:||||||||||::||.:|||.||||:.||::...||..|||:|:.|           |
Zfish  1025 GRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAQVCMDCGSLLSTL-----------L 1078

  Fly  1084 SSQPDT----------CRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKLN 1127
            ...|..          |.||..:.|:..:.:|:.|||.|.||:::||  :.||:
Zfish  1079 EKPPPNWSATRHRKTICLLCNKSDSIETVSVPYVFKYFVAELAAMNI--KIKLD 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	509/1121 (45%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	19/57 (33%)
polr1b	NP_956812.2	RNA_pol_B_RPB2	37..1130	CDD:238353	510/1123 (45%)
		RNA_pol_Rpa2_4	561..619	CDD:462028	19/57 (33%)