Protein Alignment Polr1B and rpc2

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_593690.1
• Gene: rpc2 / 2543393
• PomBaseID: SPAC4G9.08C
• Length: 1165
• Species: Schizosaccharomyces pombe
• Alignment Length: 1217
• Identity: 330/1217 - (27%)
• Similarity: 533/1217 - (43%)
• Gaps: 217/1217 - (17%)

  Fly    19 PEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKP 83
            |.|.::...:.:||        ||::..:.|.|..          :..|.||::..||..:..|
pombe    55 PAFLKVKGLVKQHL--------DSYNYFVDVDLKK----------IVQANEKVTSDVEPWFYLK- 100

  Fly    84 KVPQDVIDVRTREIYPTDSRQLHVSYS-GMCSVR-LGWSVN---------GVQKT-PINMDLGEV 136
                 .:|:|......||:..:..|.| ..|.:| |.:..|         |.|.. ..|:.:|.:
pombe   101 -----YLDIRVGAPVRTDADAIQASISPHECRLRDLTYGANIYVDIEYTRGKQVVRRRNVPIGRM 160

  Fly   137 PIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPIC---VKRSSWK 198
            |:||||..|.|......||....|...:.||.|:::|.||::.:.....:|..|.   .|:..|
pombe   161 PVMLRSNKCVLSGKNEMEMAALNECPLDPGGYFIVKGTEKVILVQEQLSKNRIIVEAEPKKGLW- 224

  Fly   199 DRGQNFSDLGMLVQTVREDESSLSNVVH------YLNNGTAKFMFSHVKRLSYVPVCLILKCLMD 257
                               ::|:::..|      |:.....|....|......:|:.::||.:..
pombe   225 -------------------QASVTSSTHERKSKTYVITKNGKLYLKHNSVADDIPIVVVLKAMGL 270

  Fly   258 YTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLF----RARFPEVPEWQ 318
            .:|:||: .||.|.|:.  |.......:.|....|:||..|...:||...    ||....:|
pombe   271 QSDQEIF-ELVAGAEAS--YQDLFAPSIEECAKLNIYTAQQALEYIGARVKVNRRAGANRLP--- 329

  Fly   319 PDDDVTDFILRERVMIHLDTYEDKFQ----LIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGH 379
            |.::..: :|...|:.|::.:..:|:    .|..|.:::........:|::.|....:.:.|.|.
pombe   330 PHEEALE-VLAAVVLAHINVFNLEFRPKAVYIGIMARRVLMAMVDPLQVDDRDYVGNKRLELAGQ 393

  Fly   380 LYQKYLSERVESWVSQVRRCLQKKLTSP------DALVTSAVMTQCMRQAGGVGRAIESFLATGN 438
            |......:..:.:.|.::..:.|.|..|      ||.....|.:..:.|  |:.||    |:|||
pombe   394 LLALLFEDLFKKFNSDLKLNIDKVLKKPHRTQEFDAYNQLTVHSDHITQ--GMVRA----LSTGN 452

  Fly   439 IASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHR--GSYFTTMRTTEARQLLPDAWGFICPVH 501
            .:.:.  ..|:.:|:..:   ::|:.|:|....:.|  ..:..|.:.:..|.|....:|.:|...
pombe   453 WSLKR--FKMERAGVTHV---LSRLSYISALGMMTRITSQFEKTRKVSGPRSLQASQFGMLCTSD 512

  Fly   502 TPDGTPCGLLNHLTLTCEISM--RPDPKLVKAIPKHLIDMGMMPLSNRRYLGEKLYVVFLDGKHL 564
            ||:|..|||:.:|.|...|:.  ..:|.:..|....:.|:.:  :|.|.......|:|:|:|..|
pombe   513 TPEGEACGLVKNLALMTHITTDEEEEPIIKLAYAFGIEDIHV--ISGRELHSHGTYLVYLNGAIL 575

  Fly   565 GHIHQSEAEKIVDELRYGKIFGTLPQMMEIGFIPFKKNGQ---FPGL---------YIATGPARM 617
            |                   ....|.:....|...:::|:   |.|:         :|:|...|:
pombe   576 G-------------------ISRYPSLFVASFRKLRRSGKISPFIGIFINTHQRAVFISTDGGRI 621

  Fly   618 MRPV----------------------WN----LKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTH 656
            .||:                      |.    ||...|||:...|:....|::..:::.|| |||
pombe   622 CRPLIIVQNGLPKVESKHIRLLKEGKWGFEDFLKQGLVEYVDVNEENDSLISVYERDITPD-TTH 685

  Fly   657 LELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFR 721
            ||:.....:..:|.|||.|.:||||||.|||.||||.:|....|..::....||.:..|..|:.:
pombe   686 LEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQLQRIDTLLYLMVYPQQPMVK 750

  Fly   722 PVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDK----- 781
            ....:.|..|....|.||.||::||:|||:|||:::||::.:|||....::....:.:.|
pombe   751 TKTIELIGYDKLPAGQNATVAIMSYSGYDIEDALVLNKSSIDRGFGRCQVFHKHSVIVRKYPNGT 815

  Fly   782 --KSSYFARHPHMPELI-KH--LDTDGLPHPGSKLSYGSPLYCYFDGEVAT-------------- 827
              :.....|.|...|:: ||  ::.|||...|.::..|.   .|.:.:..|
pombe   816 HDRIGDPQRDPETGEVVWKHGVVEDDGLAGVGCRVQPGQ---IYVNKQTPTNALDNSITLGHTQT 877

  Fly   828 ----YKVVKMDEK--EDCIVESIRQLGSFDLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQ 886
                ||...|..|  |...::.: .|.:.| |.:.::.:.:|..|...:||||:||.||||:|..
pombe   878 VESGYKATPMTYKAPEPGYIDKV-MLTTTD-SDQTLIKVLMRQTRRPELGDKFSSRHGQKGVCGV 940

  Fly   887 KYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAID 951
            ....||:||.:.|:.|||:.||||||||||:..|||.::||...:.|.:...|.|    ..|.::
pombe   941 IVQQEDMPFNDQGICPDIIMNPHGFPSRMTVGKMIELLSGKVGVLRGTLEYGTCF----GGTKVE 1001

  Fly   952 YFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQP 1016
            ...::|...||||.|.:.|.||:.|..:.|.||.|.::||:|:|||.||...|:.|.....|.||
pombe  1002 DASRILVEHGYNYSGKDMLTSGITGETLEAYIFMGPIYYQKLKHMVMDKMHARARGPRAVLTRQP 1066

  Fly  1017 IKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETG 1081
            .:||.|.||:|.||||||.||::||:.||.:||..:||.....||.:|
pombe  1067 TEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMISSDACDVDVCGQC----------------- 1114

  Fly  1082 GLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKLNE 1128
            ||......|..|.....|..:.||::.|.|..||.|:||..|..|.:
pombe  1115 GLLGYKGWCNSCQSTREVVKMTIPYAAKLLFQELLSMNIVPRLALED 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	325/1196 (27%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	10/66 (15%)
rpc2	NP_593690.1	RNA_pol_B_RPB2	63..1157	CDD:238353	326/1203 (27%)
		RNA_pol_Rpb2_4	568..629	CDD:428012	15/79 (19%)
		RNA_pol_Rpb2_5	650..690	CDD:428013	14/40 (35%)