Protein Alignment Polr1B and rpa2

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_595819.2
• Gene: rpa2 / 2541280
• PomBaseID: SPBP23A10.07
• Length: 1174
• Species: Schizosaccharomyces pombe
• Alignment Length: 1186
• Identity: 494/1186 - (41%)
• Similarity: 703/1186 - (59%)
• Gaps: 91/1186 - (7%)

  Fly     2 LEEMQQMKTIPVLTNSRPEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSP 66
            ||..:..|..|....|.|:.::..|           ||||||:.:...||.|.|...|.......
pombe     6 LERERTFKNPPKDGTSFPDLQKAVK-----------PHVDSFNALTNAGLLNYAVKEIGEKCAFD 59

  Fly    67 A-----------GEKISMKVESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWS 120
            :           |.|||.:|:.:.||||.:.........|::||.::|:...:|.....::..||
pombe    60 SITQEEGGALKFGNKISFRVDEVQIAKPMLSSRERSSINRKVYPAEARERLTTYKSRLVLKFSWS 124

  Fly   121 VNGVQKTPINMDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTR 185
            |||..:.....::|.:|||:||..|:|...:|.|::.|.|...|.||.|::.|.||::||||:.:
pombe   125 VNGGPRQSEMREVGMIPIMVRSNRCHLEGLSPAELIAHKEESEEMGGYFIVNGIEKLIRMLILPK 189

  Fly   186 RNHPICVKRSSWKDRGQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCL 250
            ||||..:.|.|:.:||.::|..|:.::.||.|:|||:|.:||||||...|.|...|....:|..:
pombe   190 RNHPTAIIRPSFANRGTSYSQYGLSIRCVRPDQSSLTNTLHYLNNGVTMFRFHWRKNEYLIPSMM 254

  Fly   251 ILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVP 315
            |||.|::.:|:||:..:|.....:.:....|:.|||..::..:|:..:...::|:.||... .|.
pombe   255 ILKALLETSDKEIFEGIVGKDLGNTFLTDRVELMLRAYKSYGLYSQTETLQYLGSKFRVVL-GVA 318

  Fly   316 EWQPDDDVTDFILRERVMIHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHL 380
            |...|.:|..|:|::.|::||...:|||:|::|||:||:....|:...:|.||...||:||.|.|
pombe   319 EDLTDVEVGRFLLQKVVLVHLREAKDKFRLLLFMIRKLYALVAGECCADNPDSPQHQEILLGGFL 383

  Fly   381 YQKYLSERVESWVSQVRR--CLQKKLTSP-----DALVTSAVMTQCMRQAGGVGRAIESFLATGN 438
            |.:.|.|::|.|::.:|.  .|..:.::|     |....:.|.::....   :|..::.||:|||
pombe   384 YGQILKEKIEDWLNSIRAQINLDVRRSAPGVDFSDRKYLTRVFSKINND---IGTKLQYFLSTGN 445

  Fly   439 IASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTP 503
            :.|.|||.|.|.:|..::||.:|..|::||||.:|||::|..::||..|:|||:||||:||||||
pombe   446 LVSNTGLDLQQATGYTVVAEKLNFYRFLSHFRMVHRGAFFAELKTTTVRKLLPEAWGFMCPVHTP 510

  Fly   504 DGTPCGLLNHLTLTCEISMRPDPKLVKAIPKHLIDMGMMPLSNRRYLGEK--LYVVFLDGKHLGH 566
            ||:||||||||...|||...|..  |..||..|:.:|:.|.|   .:|.:  ...|.||||.:|.
pombe   511 DGSPCGLLNHLARKCEIVTHPSD--VSQIPSLLLSLGVDPPS---VVGHESGWGCVQLDGKIVGW 570

  Fly   567 IHQSEAEKIVDELRYGKI-------FGT------LPQMMEIGFIPFKKNGQFPGLYIATGPARMM 618
            .....|:.:.|.||..||       .||      :|..:|||::|...|||:||||:.:.||||:
pombe   571 CTYKLAKHVADVLRLMKIEYAVKLRNGTATEPAKVPLDLEIGYVPPSHNGQYPGLYLFSNPARMV 635

  Fly   619 RPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRN 683
            |||.::....::.:|..||:||:||...||:.|..:||:|.:.|:.:|.:||:.|..|:||||||
pombe   636 RPVKHISTGELDMLGPFEQVYMDIACFPKEIVPKVSTHVEYSPTNVLSIVANMTPFSDFNQSPRN 700

  Fly   684 MYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTG 748
            ||||||||||||||......:..||||||||..||:.||..::...||.:..||||:||||||||
pombe   701 MYQCQMGKQTMGTPGTALRYRTDNKLYRLQTGQTPVVRPKLHNTYGLDHYPNGTNAVVAVISYTG 765

  Fly   749 YDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKKS-------SYFARHPHMP---ELIKHLDTDG 803
            ||||||||:||:|:||||.||::||.:...|.:|.       .:|...|...   |.::.||.||
pombe   766 YDMEDAMILNKSAHERGFGYGTVYKGESFDLSQKRRRGEPVVHHFGFAPGSTPRREWLQKLDADG 830

  Fly   804 LPHPGSKLSYGSPLYCYFDGEVATYKVVKMDEKEDCIVESIRQLGSFDL--SPKKMVAITLRVPR 866
            ||..|.||..|.|:..|:|.......:......|...|:.:|.||: |:  |..:.:.:.||:.|
pombe   831 LPFIGIKLEDGDPIVAYYDESTGQNFIETYHGTEPGFVDEVRLLGN-DVGDSECQQIHVKLRITR 894

  Fly   867 PATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAI 931
            ...|||||:||.|||||||||:|..|:||||||:.|||:.|||.|||||||.|.||::|||..|.
pombe   895 SPIIGDKFSSRHGQKGICSQKWPTVDMPFTESGMQPDIIINPHAFPSRMTIGMFIESLAGKAGAC 959

  Fly   932 HGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHM 996
            ||...|:|||.:||:.||.||||:.|...||||:|.|.:|||:.|:||.|||:.|||:|||||||
pombe   960 HGLAQDSTPFIYSEQQTAADYFGEQLVKAGYNYHGNEPMYSGITGQEMKADIYIGVVYYQRLRHM 1024

  Fly   997 VFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVC 1061
            |.||:|||:||.:...|.||:|||||.||:|||||||||:|.||.:||:||||.:.||...:.||
pombe  1025 VSDKFQVRTTGPIHNLTRQPVKGRKRAGGIRFGEMERDAVIGHGTSFLMQDRLMNCSDYAQSWVC 1089

  Fly  1062 HKCGSILAPLQRIVKRNETGGLSSQPDTCRLCG-------DNSSV---------------SMIEI 1104
            ..||||:: :...:..|..|  |:....||.|.       |.|.:               ::|.:
pombe  1090 RDCGSIIS-IMSTISMNGVG--SASEVRCRSCAKPALGLEDTSDIWQDGSGKKFVGGTNTTLIAL 1151

  Fly  1105 PFSFKYLVTELSSVNI 1120
            |..|.||..||:::||
pombe  1152 PSVFNYLTAELTAMNI 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	487/1153 (42%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	25/67 (37%)
rpa2	NP_595819.2	RNA_pol_B_RPB2	29..1172	CDD:238353	488/1163 (42%)
		RNA_pol_Rpb2_2	190..378	CDD:398318	67/188 (36%)
		RNA_pol_Rpa2_4	568..636	CDD:462028	25/67 (37%)