Protein Alignment Polr1B and rpoa-2

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_492476.1
• Gene: rpoa-2 / 172752
• WormBaseID: WBGene00008781
• Length: 1127
• Species: Caenorhabditis elegans
• Alignment Length: 1124
• Identity: 482/1124 - (42%)
• Similarity: 690/1124 - (61%)
• Gaps: 56/1124 - (4%)

  Fly    39 HVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKP------KVPQDVIDVRTREI 97
            ||||||.:::.|...:|:.:....:....|:.::||..|..:.||      |:..|     |..:
 Worm     9 HVDSFDFLVSKGCQFAAQAVPAEKFRLKNGDAVTMKFTSAQLHKPTLDTGAKLTSD-----TLPL 68

  Fly    98 YPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVPIMLRSKACNLGQATPEEMVKHGEHD 162
            .|.:.||..::|:|...|.:...|||.:...|.:.||:|||||||:.|:|...:.:|:|..||..
 Worm    69 LPAECRQRGLTYAGNLKVGIDVHVNGSRLDIIEIILGKVPIMLRSEGCHLRGMSRKELVVAGEEP 133

  Fly   163 SEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQTVREDESSLSNVVHY 227
            .|.||.|::.|:||::|:||..|||.||.:.|.::|::|:.||:.|:::::|:|:.:::...:||
 Worm   134 IEKGGYFIVNGSEKVIRLLIANRRNFPIAIIRKTFKEKGKLFSEFGVMMRSVKENHTAVMMTLHY 198

  Fly   228 LNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNEN 292
            |:.||.:......:.:.|||:..|:|.|.|..|..|.....:|...||:|.||:..||.:.|.|.
 Worm   199 LDTGTMQLALQFRREIFYVPLMYIVKALTDKNDAVISAGFKRGRNQDQFYSSCILNMLAQCQEEE 263

  Fly   293 VYTHAQCKSFIGNLFRARFPE-VPEWQPDDDVTDFILRERVMIHLDTYEDKFQLIVFMIQKLFQC 356
            :.........||:.||....: |..|:.|.:...||:||.|:||||:.|:||..:.:|.|||...
 Worm   264 ILNQEAAIRAIGSRFRVAVSDRVAPWEDDLEAGRFIIRECVLIHLDSDEEKFHTLAYMTQKLIAL 328

  Fly   357 AQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPDALVTSAVMTQCM- 420
            .:|:...|..|:...||..:.||:....|.||:|:.:..|||.|:...:..|.::|||.:.:.:
 Worm   329 VKGECAPETPDNPQFQEASVSGHILLLILRERMENIIGMVRRKLEYMSSRKDFILTSAAILKALG 393

  Fly   421 -RQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTT 484
             ...|.:.|.:..||||||:.:|.||.|.|.||..::||.||::|::|||||||||::|..||||
 Worm   394 NHTGGEITRGMAYFLATGNLVTRVGLALQQESGFSVIAERINQLRFVSHFRAIHRGAFFMEMRTT 458

  Fly   485 EARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKLVKAIPKHLIDMGMM------- 542
            :.|:|.|:|||||||||||||.|||||||:|.:|.|.  .|......:|..|.::||.
 Worm   459 DVRKLRPEAWGFICPVHTPDGAPCGLLNHVTASCRIV--TDLSDNSNVPSLLAELGMYTHKTVAL 521

  Fly   543 --PLSNRRYLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIF--GTLPQMMEIGFIPFK--- 600
              |       ||:||.|.::|:.||::..::|..|...||..|:.  ..:|...||..:...
 Worm   522 APP-------GEELYPVLMNGRFLGYVPITKAASIERYLRCAKVAKDARIPYTSEIALVRRSTDI 579

  Fly   601 KN--GQFPGLYIATGPARMMRPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTH 663
            ||  .|:||:||.:...|::|||.||....||:|||.||:|:.:.:|.:|..|..|.|.||..:.
 Worm   580 KNIQTQYPGIYILSDAGRLIRPVRNLAMDAVEHIGTFEQVYLSVVLDPEEAEPGVTMHQELHPSC 644

  Fly   664 FMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNI 728
            ..|...||||.||:||||||:||||||||||||....|..:|.||:||||.|..|:.:...|:..
 Worm   645 LFSFAGNLIPFPDHNQSPRNVYQCQMGKQTMGTAVHAWHSRADNKMYRLQFPQQPMLKLEAYEKY 709

  Fly   729 QLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTK---FLTLDKKSSYFARHP 790
            ::|::.:||||.|||||||||||||||.||||:|:||||:|::.|.:   .:|..::.:.|.|:|
 Worm   710 EMDEYPLGTNACVAVISYTGYDMEDAMTINKASYQRGFAHGTVIKVERINLVTERERKTIFYRNP 774

  Fly   791 HMPELIKHLDTDGLPHPGSKLSYGSPLYCYFDGEVATYKVVKMDEKED--CIVESIRQLGSFDLS 853
            .  |.||.:..||||.||.:.......|..|:.|...::..|....|.  |.:..|.:.|..| |
 Worm   775 R--EEIKTVGPDGLPIPGRRYFLDEVYYVTFNMETGDFRTHKFHYAEPAYCGLVRIVEQGEGD-S 836

  Fly   854 PKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIA 918
            ..|...|..|:.|...||||||||.|||||.|..:|.|.|||:|:|::|||:||||||||||||.
 Worm   837 GAKHALIQWRIERNPIIGDKFASRHGQKGINSFLWPVESLPFSETGMVPDIIFNPHGFPSRMTIG 901

  Fly   919 MMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADI 983
            ||||:||||.||.||..|||:||.|:|:||||::||::|...||||||.|..|||||||:|...|
 Worm   902 MMIESMAGKAAATHGENYDASPFVFNEDNTAINHFGELLTKAGYNYYGNETFYSGVDGRQMEMQI 966

  Fly   984 FFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDR 1048
            |||:|:|||||||:.||:|||:||.::..||||:||||:|||:|||||||||:|:||.:|:||||
 Worm   967 FFGIVYYQRLRHMIADKFQVRATGPIDPITHQPVKGRKKGGGIRFGEMERDAIIAHGTSFVLQDR 1031

  Fly  1049 LFHNSDKTHTLVCHKCGSILAPLQRI--------VKRNETGGLS-SQPDTCRLCGDNSSVSMIEI 1104
            |.:.||:.....|.:|||:|:.|...        .||.:...|. ::...||.|..:..|.::::
 Worm  1032 LLNCSDRDVAYACRRCGSLLSVLMSSRAGSHLLKKKRKDDEPLDYTETQRCRTCDKDDQVFLLQV 1096

  Fly  1105 PFSFKYLVTELSSVNINAR 1123
            |..|:||..||:::|:..:
 Worm  1097 PRVFRYLTAELAAMNVKIK 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	482/1124 (43%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	18/61 (30%)
rpoa-2	NP_492476.1	RNA_pol_B_RPB2	5..1116	CDD:238353	482/1124 (43%)
		RNA_pol_Rpb2_2	<216..339	CDD:398318	44/122 (36%)
		RNA_pol_Rpa2_4	538..600	CDD:462028	18/61 (30%)