Protein Alignment Polr1B and RpI135

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_310152.5
• Gene: RpI135 / 1271371
• VectorBaseID: AGAMI1_014708
• Length: 1145
• Species: Anopheles gambiae
• Alignment Length: 1149
• Identity: 651/1149 - (56%)
• Similarity: 833/1149 - (72%)
• Gaps: 37/1149 - (3%)

  Fly     8 MKTIPVLTNSRPEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKIS 72
            ||.:|.|||.|||||:||||.:..|||||.||:|||:.||..|:::....::|..:....|.:|.
Mosquito     1 MKLLPELTNLRPEFKEIPKKQNEILANLGRPHIDSFNYMLDEGIEDVLSRLVPVCFEMANGSRIK 65

  Fly    73 MKVESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVP 137
            :::..|.||.|.||..:::|..:.::|::.||...:|:|||::.|.|.::|:.::|:..::|.:|
Mosquito    66 LRITDISIAPPTVPMMLVEVAEKRVFPSECRQKSDTYAGMCTITLNWELDGMPQSPLTREMGRIP 130

  Fly   138 IMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQ 202
            |||||.||||..|||||:|..|||:.||||.||:|||||::||||.||||:||.|.|::|:|||:
Mosquito   131 IMLRSNACNLANATPEELVARGEHEDEWGGYFVVRGNEKLIRMLISTRRNYPIAVNRNTWRDRGK 195

  Fly   203 NFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRL 267
            :||..|:.::.||||:.|..||:|||.|||||.|.|..:.||::||.:|||.|.|.:|.|||.:|
Mosquito   196 DFSATGVFIRCVREDQYSTRNVLHYLTNGTAKLMISVSRALSFIPVMMILKALGDRSDNEIYKKL 260

  Fly   268 VQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEV--PEWQPDDDVTDFILRE 330
            ....||||||..|:.||||::..||:::..:|:|::|.|.|.|..::  |.|..|:....|:|:.
Mosquito   261 TACDESDQYYKRCIMAMLRDLHAENLHSSQECRSYMGMLLRRRLMDINLPAWYSDEQAGHFLLQH 325

  Fly   331 RVMIHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQ 395
            .|:||||:.||||.|:|.|:.||:...||::.||::|..||||:||.||:||..|.|...|.:..
Mosquito   326 CVLIHLDSVEDKFNLLVHMVHKLYAVVQGRHAVESLDGTMMQEILLGGHIYQGLLREMCLSTMQY 390

  Fly   396 VRRCLQK---KLTSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMA 457
            ||..|.|   ..|||  :||:..:.|.::...|.......||||||:|..|.:||||::||||:|
Mosquito   391 VRINLMKLCPDRTSP--MVTTHELAQALKNVAGFQHPFTMFLATGNLAKATEMGLMQSTGLVIIA 453

  Fly   458 ENINRMRYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISM 522
            ||||||||||||||:||||||.||||||||||||||||||||||||||.|||||||:|..|.:|:
Mosquito   454 ENINRMRYMSHFRAVHRGSYFLTMRTTEARQLLPDAWGFICPVHTPDGEPCGLLNHMTSDCTVSV 518

  Fly   523 RPDPKLVKAIPKHLIDMGMMP----------LSNRRYLGEKLYVVFLDGKHLGHIHQSEAEKIVD 577
            ..||:||..||..|:.:||.|          ||:     :..|||.|:||.||.:.::.|.::|.
Mosquito   519 TQDPELVANIPATLVSLGMQPFGGDAGSFGTLSH-----DDGYVVMLEGKMLGMLARATASQVVQ 578

  Fly   578 ELRYGKIFG-TLPQMMEIGFIPFKKNGQFPGLYIATGPARMMRPVWNLKWKRVEYIGTLEQLYME 641
            :||..||.| |:|...||.|:|.::.||:|||::..|||||||||.||...:.|.||:.||:||:
Mosquito   579 KLRLLKIEGKTIPNQTEIAFVPAREGGQYPGLFLFVGPARMMRPVKNLLCGKTELIGSFEQVYMD 643

  Fly   642 IAIDAKEMYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAA 706
            |.:..:|.||..|||.|||||.||||||.||||||.|||||||||||||||||||||.||.||..
Mosquito   644 ICVTPEEAYPQLTTHAELAKTSFMSNLAQLIPMPDCNQSPRNMYQCQMGKQTMGTPCHNWDKQCI 708

  Fly   707 NKLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSI 771
            .|:||||||.||||||||:|||.||::||||||||||||||||||||||||||||:|||||.|:|
Mosquito   709 AKMYRLQTPATPLFRPVHHDNIALDNYAMGTNAIVAVISYTGYDMEDAMIINKAAFERGFAAGNI 773

  Fly   772 YKTKFLTLDKKSSYFARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFDGEVATYKVVKMDEK 836
            ||.:::.| ...|:|||:|....|...||.||||..|::|:.|:|||||||....||.||.....
Mosquito   774 YKHEYVEL-TGDSFFARNPKDATLNPFLDNDGLPFKGAQLTKGTPLYCYFDVNDHTYHVVSYQGY 837

  Fly   837 EDCIVESI----------RQLGSFDLS-PKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPA 890
            |:.||:::          |.:|...:: ..|.:.:|.||||..::||||||||||||||||.:||
Mosquito   838 EEAIVDNVKLGAPLQDAGRGIGRGGMAIVTKQLILTYRVPRNPSVGDKFASRAGQKGICSQHWPA 902

  Fly   891 EDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYFGK 955
            .||||||||:||||:||||||||||||||||||||||.||..|.|:||||||:.|.||||||||:
Mosquito   903 IDLPFTESGMIPDIIFNPHGFPSRMTIAMMIETMAGKTAACQGLVHDATPFRYDESNTAIDYFGR 967

  Fly   956 MLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGR 1020
            :||..||:||||||:|||||||||..||||||||||||||||.|||||||||.::..||||.|||
Mosquito   968 LLEQSGYDYYGTERMYSGVDGREMKVDIFFGVVHYQRLRHMVSDKWQVRSTGPIDQLTHQPNKGR 1032

  Fly  1021 KRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKR--NETGGL 1083
            .|||||||||||||.||||||:|||||||.|.|||...|||.:||:::.|:..:.||  :.:..|
Mosquito  1033 SRGGGVRFGEMERDGLISHGASFLLQDRLVHGSDKVVALVCRRCGTLIGPIDSVTKRLADNSNQL 1097

  Fly  1084 SSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKLN 1127
            ...|.|||||.|:..:..:|||:.||:||::|:|:|||.:.:|:
Mosquito  1098 QHVPATCRLCEDDKEIGHVEIPYIFKFLVSQLTSMNINVKLQLS 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	632/1118 (57%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	25/55 (45%)
RpI135	XP_310152.5	None