Protein Alignment Polr1B and polr1b

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_002940442.1
• Gene: polr1b / 100485503
• XenbaseID: XB-GENE-1008539
• Length: 1135
• Species: Xenopus tropicalis
• Alignment Length: 1132
• Identity: 500/1132 - (44%)
• Similarity: 726/1132 - (64%)
• Gaps: 59/1132 - (5%)

  Fly    29 SRH--LANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKPKVPQDVID 91
            |:|  |.::...|:|||::.:|.||..:.:.|.|..: :...:|:::::....|..|.||:..|
 Frog    30 SQHPPLQDITRAHIDSFNQAMTEGLSLAVQAMKPLEF-TYKNDKVALQIVDAVITPPLVPKGSI- 92

  Fly    92 VRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVPIMLRSKACNLGQATPEEMV 156
            .:.::|||.:.|....:|.|..:..:.||:||:||..|...||.:|||::||.|||....|::::
 Frog    93 CKEQKIYPAECRGRRSTYRGKLTADVSWSLNGLQKGIIKQTLGHIPIMVKSKFCNLYDLNPKQLL 157

  Fly   157 KHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQTVREDESSL 221
            :|.|.:.|.||.|:|.|.||::|||||.|||.||.:.|..||:||..::..|:.::.||::.:::
 Frog   158 EHHEEEQEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKNRGPGYTQYGISLRCVRDEHTAV 222

  Fly   222 SNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLR 286
            :..:|||.||:....|.:.|.|.::|:...||.|:||:|.:|:..|::|.|.:.:|..|:..|||
 Frog   223 NMNLHYLENGSVMVNFIYQKELFFIPLGFALKALVDYSDYQIFTELIKGKEENSFYRDCMTQMLR 287

  Fly   287 EVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDVTDFILRERVMIHLDTYEDKFQLIVFMIQ 351
            .|..|..::......::|..||.:| .:|:|..|:...:|::.:.:.|||.|..:||.::..|.|
 Frog   288 AVVEEGCHSQKNVLKYLGERFRVKF-YLPDWFTDEQAAEFLISQCICIHLKTNVEKFYMLCMMTQ 351

  Fly   352 KLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPDALVTSAVM 416
            |||..|:.....||.||.|.|||:.||.|...:|.|::|||:..|:..|.|:.......:::..|
 Frog   352 KLFTFAKDGCMEENPDSLMYQEVMTPGQLLLMFLKEKMESWLLGVKVNLDKRAHKYTVDLSTETM 416

  Fly   417 TQCMRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTM 481
            .:.......:.:..|..|||||:.|:||||::|:||||::|:.:|.:||:||||.:|||:.|..|
 Frog   417 MKVFTSTSDLTKTCEYLLATGNLRSKTGLGMLQSSGLVVVADKLNFIRYLSHFRCVHRGAAFAKM 481

  Fly   482 RTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKLVKAIPKHLIDMGMMPLSN 546
            |||..|:|||::|||:||||||||.||||:||:|..|||..:.....:  :|..|..:||.|:..
 Frog   482 RTTSVRRLLPESWGFLCPVHTPDGEPCGLMNHMTAACEIVTQTSYNTL--LPLLLCSLGMTPVDG 544

  Fly   547 RR-YLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKI--FGTLPQMMEIGFIPFK-KNGQFPG 607
            .. .|....|.|.|||..:|.:.::.|..:|..||..|:  ...:|...||..||.. |...:||
 Frog   545 TAGKLFADCYPVMLDGAMVGWVEKTIAPGLVSALRNYKVKHEKNVPPWTEIVLIPMTGKASLYPG 609

  Fly   608 LYIATGPARMMRPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFMSNLANLI 672
            |::.|.|.||:|||.||...:.|.:|||||:::.:|:...::.|..|||.|......:|.:||.|
 Frog   610 LFLFTTPCRMVRPVRNLALGKEELLGTLEQVFLNVAVYEGDIVPGETTHQEFFPHSMLSVVANFI 674

  Fly   673 PMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQLDDFAMGT 737
            |..|:||||||||||||||||||.|.:.:..::.|||||||||.:||.||..||..::|::.:||
 Frog   675 PFSDHNQSPRNMYQCQMGKQTMGFPLMTYQDRSDNKLYRLQTPQSPLVRPSMYDYYEMDNYPIGT 739

  Fly   738 NAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKK------SSYFARHPHMPELI 796
            ||||||||||||||||||::||:::|||||:||:|||..:.|.||      :..|...|....:.
 Frog   740 NAIVAVISYTGYDMEDAMVLNKSSWERGFAHGSVYKTDHVDLSKKLKDGEDNLVFGIKPDDERVK 804

  Fly   797 KHLDTDGLPHPGSKLSYGSPLYCYFD---GE--VATYKVVKMDEKEDCIVESIR------QLGSF 850
            ..||:||||..|:.|.:|.|.|.|.:   ||  ||.||     .||:|::::|:      ..|.|
 Frog   805 GRLDSDGLPAVGAVLQFGDPYYGYLNLNTGESFVAYYK-----SKENCVIDNIKICSNDIGFGKF 864

  Fly   851 DLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRM 915
                 |.|.:|:|:||..|||||||||.|||||.|:.:|:||:||||||::|||:||||||||||
 Frog   865 -----KSVCVTMRIPRNPTIGDKFASRHGQKGILSRLWPSEDMPFTESGMVPDILFNPHGFPSRM 924

  Fly   916 TIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMT 980
            ||.|:||:||||.||:||..:|||||.|||||:|::|||:||.|||||:||||:||||:.|.|:.
 Frog   925 TIGMLIESMAGKSAALHGLCHDATPFTFSEENSALEYFGEMLRAGGYNFYGTEKLYSGISGLELE 989

  Fly   981 ADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLL 1045
            ||||.|||:||||||||.||:|||:|||.:..|:||:.||...||:||||||||||::||.:|||
 Frog   990 ADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPVGGRNVQGGIRFGEMERDALLAHGTSFLL 1054

  Fly  1046 QDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDT----------CRLCGDNSSVS 1100
            .||||:.||::...||.:|||:|:|.           |...|.:          |.:|....:|.
 Frog  1055 HDRLFNCSDRSTAHVCIECGSLLSPF-----------LEKPPPSWSSIRNRKHHCEVCDRTDTVE 1108

  Fly  1101 MIEIPFSFKYLVTELSSVNINARFKLN 1127
            .:.:|:.|:|.|.||:::||:.:..::
 Frog  1109 TVSVPYVFRYFVAELAAMNISVKLSVS 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	497/1120 (44%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	19/57 (33%)
polr1b	XP_002940442.1	RNA_pol_B_RPB2	38..1132	CDD:238353	497/1119 (44%)
		RNA_pol_Rpb2_2	186..374	CDD:398318	65/188 (35%)
		RNA_pol_Rpa2_4	563..621	CDD:462028	19/57 (33%)