Protein Alignment Polr1B and polr3b

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_001121521.1
• Gene: polr3b / 100158643
• XenbaseID: XB-GENE-5799940
• Length: 1134
• Species: Xenopus tropicalis
• Alignment Length: 1205
• Identity: 353/1205 - (29%)
• Similarity: 557/1205 - (46%)
• Gaps: 169/1205 - (14%)

  Fly     5 MQQMKTIPVLTNSRPEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGE 69
            :.|.:.|..:...:.::|.:|..|.  :..|...|:|||:..:.   |...|.|       .|.|
 Frog    11 LSQEELIAPVDTVQEKWKLLPAFLK--VKGLVKQHIDSFNYFIN---DEIKKIM-------KANE 63

  Fly    70 KISMKVESIWIAK--------PKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQK 126
            |::...:.:|..|        |.| ::..:| ||.:.|.:.|...::||...:|.:.:: .|.|:
 Frog    64 KVTSDADPMWYLKYLNIYVGLPDV-EESFNV-TRPVSPHECRLRDMTYSAPITVDIEYT-RGSQR 125

  Fly   127 TPIN-MDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPI 190
            ...| :.:|.:||||||..|.|...||.|..|..|...:.||.|:::|.||::.:.....:|..|
 Frog   126 IIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRII 190

  Fly   191 CVKRSSWKDRGQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCL 255
            .        .......:|..|.:...::.|.:|:|  :..|  :|...|......:|:.:|.|.:
 Frog   191 V--------EADRKGTVGASVTSSTHEKKSRTNLV--VKQG--RFYLKHNTLTEDIPIAIIFKAM 243

  Fly   256 MDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRAR---FPEVPEW 317
            ...:|:||    ||...::::.::.....|.|.|...::|..|...||||..|.:   ....|:.
 Frog   244 GVESDQEI----VQMIGTEEHVIAAFAPSLEECQKAQIFTQMQALKFIGNKVRRQRMWGSSGPKK 304

  Fly   318 QPDDDVTDFILRERVMIHLDTYEDKFQ----LIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPG 378
            ...|:..: :|...::.|:...|..|:    .|..|::::. .|||..||::.|....:.:.|.|
 Frog   305 SKIDEARE-LLASTILTHVPVKEFHFRTKCIYIAVMVRRVI-LAQGANKVDDRDYYGNKRLELAG 367

  Fly   379 HLYQKYLSERVESWVSQVRRCLQKKLTSPDALVTSAVMTQCMRQ---AGGVGRAIESFLATGNIA 440
            .|......:..:.:.|::::...:.:  |........:.:.|||   ..|:..||.|    ||.:
 Frog   368 QLLSLLFEDLFKKFNSEMKKIADQVI--PKQRAAQFDVVKHMRQDQITNGMVNAISS----GNWS 426

  Fly   441 SRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHR--GSYFTTMRTTEARQLLPDAWGFICPVHTP 503
            .:.  ..|...|   :.:.::|:.|::....:.|  ..:..|.:.:..|.|.|..||.:||..||
 Frog   427 LKR--FKMDRQG---VTQVLSRLSYIAALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTP 486

  Fly   504 DGTPCGLLNHLTLTCEIS--MRPDPKLVKAIPKHLIDMGMMPLSNRRYLGEKL-----YVVFLDG 561
            :|..|||:.:|.|...|:  |...|.:..|....:.|:.::       .||:|     ::|||:|
 Frog   487 EGEACGLVKNLALMTHITTDMEDGPIIKLAANLGVEDVNLL-------CGEELSYANVFLVFLNG 544

  Fly   562 KHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEIGFIPFKKNGQFPGLYIATGPARMMRPVWNLKW 626
            ..||.|.  :.:|:|:..|..:..|.:.:     |:....|.....:||::...|:.||...:|.
 Frog   545 NILGVIR--DHQKLVNTFRLMRRAGYINE-----FVSISTNISDRCVYISSDGGRLCRPYIIVKN 602

  Fly   627 KR--------------------------VEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFM 665
            :|                          |||:...|:....:|: .:......|||||:.....:
 Frog   603 QRSAVTNKHIQELSQGYRSFEDFLHESLVEYLDVNEENDCNVAL-YEHTITKHTTHLEIEPFTLL 666

  Fly   666 SNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQL 730
            ...|.|||.|.:||||||.|||.||||.|||...|...:....:|.|..|..|:.:....:.|:.
 Frog   667 GVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQRPMVKTKTIELIEF 731

  Fly   731 DDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKKSSYFARHPHMP-- 793
            :....|.||.|||:||:|||:|||:::|||:.:|||....:||....||.:.|:........|
 Frog   732 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYSNQTFDKVMGPML 796

  Fly   794 ------ELIKH--LDTDGLPHPGSKLS-------------YGSPLYCYFDGEVATYKVVKMDEK- 836
                  ::.:|  ||.||:..||.|:.             ..:||......:...||.|.:..|
 Frog   797 DANTRKQIWRHEILDADGICSPGEKVENKQVLVNKYMPTVTQTPLEGSSVPQQPQYKDVPITYKG 861

  Fly   837 -EDCIVESIRQLGSFDLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGL 900
             .|..:|.:  :.|.:.....::.|.||..|...|||||:||.||||:|....|.||:||.|:|:
 Frog   862 PTDSYIEKV--MISSNAEDAFLIKILLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCETGI 924

  Fly   901 IPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTA----IDYFGKMLEAGG 961
            .|||:.||||:|||||:..:||.:|||...:.|..:..|.|..|:....    |.|        |
 Frog   925 CPDIIMNPHGYPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLIRY--------G 981

  Fly   962 YNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGV 1026
            |||.|.:.:.||:.|..:.|.|:||.|:||:|:|||.||...|:.|.....|.||.:||.|.||:
 Frog   982 YNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGL 1046

  Fly  1027 RFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDTCR 1091
            |.||||||.||.:||:.||.:||..:||.....||.|||.:              |.|.   .|.
 Frog  1047 RLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGKCGLL--------------GYSG---WCH 1094

  Fly  1092 LCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKL 1126
            .|..:..||.:.||::.|.|..||.|:||..|.||
 Frog  1095 FCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKL 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	346/1172 (30%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	12/54 (22%)
polr3b	NP_001121521.1	RNA_pol_B_RPB2	39..1128	CDD:238353	346/1172 (30%)
		RNA_pol_Rpb2_4	540..601	CDD:428012	18/67 (27%)
		RNA_pol_Rpb2_5	622..662	CDD:428013	10/40 (25%)