Protein Alignment Plc21C and Plcb2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_063140803.1
• Gene: Plcb2 / 85240
• RGDID: 621004
• Length: 1188
• Species: Rattus norvegicus
• Alignment Length: 1275
• Identity: 469/1275 - (36%)
• Similarity: 700/1275 - (54%)
• Gaps: 172/1275 - (13%)

  Fly    15 EVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRP 79
            :|...|..||:||:|||::...:||.:|||.||::|||..|:.|::.||:.:|||.|.|::||.|
  Rat    12 KVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIP 76

  Fly    80 KDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
            |..|||::..:. |.:....||.||..|.|.|.:||.||...:.::.:.|.:.::.||......|
  Rat    77 KSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTAN 141

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKF 208
            .|...||.|...||.:|:...|:|||||..::|   ..||||||.||....|..||.|:|:...|
  Rat   142 ASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMF---PADRKRVEAALSACHLAKGKNDAINPEDF 203

  Fly   209 QFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARA 273
            ....:.:....|..|.|::.:|.|....:| ..|:...|.:|:|:.|||||||.:|:|.|.|.:.
  Rat   204 PESVYKSFLMSLCPRPEIDEIFTSYHAKAK-PYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQV 267

  Fly   274 KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            :.||.:|||:..|.|:||||.:|.:.:|.|.:|.::|...|.:..||.||::|||||||||||||
  Rat   268 QALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLT 332

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESAFK 401
            ..|.:|.||.|:|||.||:||||||||.|.|:  .|||:|.||:|...:|..|:.:|||||||||
  Rat   333 AGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFK 397

  Fly   402 TSEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKN 465
            ||.||||||||||. :||||||:|.|||.:||:.||.:||::.||:|.|.||.|..||.||:|||
  Rat   398 TSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKN 462

  Fly   466 KKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATG 530
            ||.              |...||:.||            :..|:|    :||...|.   .|...
  Rat   463 KKN--------------QFSGPASPNK------------KPDGVS----EGGFPSSV---PVEED 494

  Fly   531 TG-TGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETE 594
            || |.............:::.:..::.:|:.|.:...:.:|...|              |..|..
  Rat   495 TGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGT--------------AGLEVT 545

  Fly   595 AGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPA 659
            |..|:|:||||:||..|.|||.:.:|||.|.:|||.|.:|..||.:..::||:|||.|:|||||.
  Rat   546 AYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPK 610

  Fly   660 GTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPF 724
            |||.||||:|||:|||||||:|||||||:||.||.|:.:||:|.:||||||.|||||.|::.:||
  Rat   611 GTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPF 675

  Fly   725 AESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTK-TVRDNGMNPLYDE 788
            :...:|.::|.|:||||:|||||:::...|:|||:::|||.|. ::::||| :...|.:||::.|
  Rat   676 SVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDP-KRRYRTKLSPTANSINPVWKE 739

  Fly   789 EPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVV 853
            |||:|:|:::|||||:|||..|||||.||||::|:..|..||.|:.||||...|:.:.:||:.:.
  Rat   740 EPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLE 804

  Fly   854 VKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADED--LSKSFVFVQVGGQK 916
            :||||||..::...||||||||.|..:|:.::|.      |..||..|.  :.|.|..:.|..|
  Rat   805 MKDYVPDTWADLTVALANPIKYFSAHDKKSVKLK------EVTGSLPEATLIQKLFSGIPVASQ- 862

  Fly   917 KELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIR 981
                               |..|.:|         .|.|.     .||..:.:....:.|
  Rat   863 -------------------SNGAPVS---------AGNGS-----TAPGTKAKEEATKEV----- 889

  Fly   982 QVESSQFDVDLVLAEP----LEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEG 1042
                         |||    ||::.:.|.|.:           |:::|:||..::..:.:...|
  Rat   890 -------------AEPQTTSLEELRELKGVVK-----------LQRRHEKELRELERRGARRWE- 929

  Fly  1043 KKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDG 1107
                     :|::|.:.:    |:...:|..   :|.|..|..|.:.......|.:......|:|
  Rat   930 ---------ELLQRGAAQ----LAELQDPAA---SCKLRPGKGSRKKRIVPCEETIVVPREVLEG 978

  Fly  1108 ---RTQE--SRLRSACREY-TSQYRELQEKYHEAIYSAAEKVL---KTSQTGQTKQLKASLDKVT 1163
               |.|:  .||....::. ..|||.:.::..:.:.....|::   :..|..:.|..|.:.:..|
  Rat   979 PDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDT 1043

  Fly  1164 GEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQH 1228
            .|:..:|:..|...::.:..|..|:....|:|||:.:|.::..|....::.:|.:|..::|:::.
  Rat  1044 KEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQ 1108

  Fly  1229 DSV------------RNALAEHRSKARQILDKEAES-RSC 1255
            .:.            ..||||:.:|.:.:..:..|| |:|
  Rat  1109 TACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRAC 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	50/125 (40%)
		EFh_PI-PLC21	151..305	CDD:320043	60/153 (39%)
		EF-hand motif	151..180	CDD:320043	11/28 (39%)
		EF-hand motif	187..216	CDD:320043	9/28 (32%)
		EF-hand motif	225..255	CDD:320043	8/29 (28%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	185/388 (48%)
		C2_PLC_like	736..855	CDD:175974	59/119 (50%)
		PTZ00121	<981..>1253	CDD:173412	56/297 (19%)
Plcb2	XP_063140803.1	None