Protein Alignment Plc21C and plch1

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_073786090.1
• Gene: plch1 / 566479
• ZFINID: ZDB-GENE-060503-398
• Length: 1795
• Species: Danio rerio
• Alignment Length: 1520
• Identity: 377/1520 - (24%)
• Similarity: 625/1520 - (41%)
• Gaps: 414/1520 - (27%)

  Fly    13 SVEVPQ-------------ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQNNELDILD 63
            |:.|||             .:|.|.:.::            ::..:||.. |:::|::.     .
Zfish    44 SMAVPQKCRLAYIVERCMSVMQSGTQMVK------------LKTGSKGLVRLFYLDEHR-----S 91

  Fly    64 IATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEK----------TVTVCHGSDFVNMTFVNFC 118
            ....|..|..:.||...|:..:  ||.|.|..:..:          ..|:.||:   :|..::..
Zfish    92 CIRWRPSRKSEKAKITIDSLYK--VTEGRQSDIFHRHAEGSFDPSCCFTIYHGN---HMESLDLV 151

  Fly   119 CTRRDIAQLWTDGLIKLAYSLAQLNG-SAIMFLQKAHTKLCLQ----VDKSGRIPVKNIIKLFAQ 178
            .:..:.|:.|..|   |.|.:|.::. .::...|:.|.:...|    .||:|    ..::
Zfish   152 TSNSEEARTWVTG---LRYLMAGISDEDSLAKRQRTHDQWMKQTFEEADKNG----DGLL----- 204

  Fly   179 NKEDRKRVEKALDVTGLPSGKVDSISVSKFQ------------FEDFYNLYKYLTQRSEVERLFD 231
            |.|:..::...::| .||..||..:    ||            ||:|...||.::.|.::..|.
Zfish   205 NMEEIYQLLHKMNV-NLPRRKVKQM----FQEADTDDQQGTLTFEEFTVFYKMMSLRRDLFLLL- 263

  Fly   232 SIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDG 296
             :..:.|:..::..:|..||...|   :::.:     .|....::|.::|.::.|.|.|.|.::|
Zfish   264 -MCFSDKKDHLTAEELGNFLRVEQ---KMSSV-----TPECCLDIINKFEVSEENKQNGVLGIEG 319

  Fly   297 FLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRC 361
            |..|:......:..|...::..|||||:.:|||.|||||||||.||...|..::|...|.|||||
Zfish   320 FTNYMRSPACDVFNPQHHEINQDMDQPICNYFIASSHNTYLTGDQLLSHSKTDMYAWVLQAGCRC 384

  Fly   362 VELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANY 426
            ||:|.|:|...||::.||||...:|..|.|:|.|.:.||..:|:|||||.||||:.:||.|||.:
Zfish   385 VEVDCWDGPDGEPMVQHGYTLTSKITFKSVIETINKYAFVNNEFPVILSIENHCSIQQQKKIAQH 449

  Fly   427 CREIFGDML-LDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAAN 490
            .:|||||.| :.:.|:..|.:    ||.|.:|:.||::|.|            :.|:.:...|..
Zfish   450 LKEIFGDKLDVGEALNKDPKQ----LPSPNLLKGKILLKGK------------RLPSYLSADAEE 498

  Fly   491 NKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANG---------------------DVATGTGTG 534
            .:::..:|.|          ...:|..:..||:||                     .:.....|.
Zfish   499 GEVSDDDSAD----------EIEDDFKLKNSTSNGPSQHQVESHIRKKLDSLMKESQIGDKEDTD 553

  Fly   535 S----AAGTAGHAPPLQQIRQSSKDSTGSSDSDS--------------------SSEDESLPNTT 575
            |    |...|.|....:.:|::|||....|.|.|                    .:||:|...
Zfish   554 SFSIRALLRATHEGLQRNLRKNSKDGMKKSQSRSFISNLKHKRHSKSRLKCQSVETEDDSQQE-- 616

  Fly   576 PNLPSGNE-PPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLK 639
               |||.: ....:.:|..:...::|.||.:...:  :|.|..::.:.| .:.||.|.:|..|:.
Zfish   617 ---PSGGQFNRGGRRRKTIKLSRDLSDLVVFTNSV--ASQECLDEGSPC-NVLSFSEARAQNLVH 675

  Fly   640 ERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNAR 704
            .|...|:.:|:.||||:||:..|.|||||.||.:||.||||||||:||....||||...|..|..
Zfish   676 HRAERFLTFNQRQLSRIYPSAYRIDSSNFNPQTYWNVGCQLVALNYQTEGRMMQLNRAKFMVNGG 740

  Fly   705 SGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQ--------FLTDKR--ANTFVEVD 759
            |||:|||..|  |....:|.::..:.......:.|.::|||        .|.|:.  .:.||||:
Zfish   741 SGYVLKPSLM--SKGAFNPLSDEPLPANPKKQLVIKIISGQQLPKPPDSMLGDRGEIIDPFVEVE 803

  Fly   760 MYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVL 821
            :.|||.|..::  :|:.|.|||.||:: ||...| .:.:||:|.:|...::.   |...:|.|.:
Zfish   804 IIGLPVDCCKE--QTRVVDDNGFNPVW-EETLSF-TLHMPEVALVRFLVWDHDPIGRDFVGQRTI 864

  Fly   822 PVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKY----------- 875
            ....|.||||||.|     :.:..||:|:.:.|.|.    ...::..:.|| .|
Zfish   865 AFSSLMPGYRHVYL-----EGMTEASIFVHITVHDI----YGKWSPLVLNP-SYTIMHLLGANKG 919

  Fly   876 --------------QSELE--------KRDIQLSVL--TDEAEALG----------------SAD 900
                          :|.::        ||.|...:|  |..|.|.|                .:.
Zfish   920 RQLRGFRGLFNRSSKSSVDTHNGVPPRKRSITDHLLRRTASAPAKGRKKNKMPLAEATYDRKQST 984

  Fly   901 EDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVD---------VTVDRTDGGRGE 956
            ||...:||..::|.:|           :.:|||     |:|.:|         .|.::.:...|.
Zfish   985 EDSQSTFVEKRMGNRK-----------ALQHRP-----ASMPLDKLLHSNLNLSTPEQEESDPGA 1033

  Fly   957 DSI----------SIVAPSIQHQHSLDQSVSTS-IRQVESSQFDVDLVL---AEPLEKILDHKSV 1007
            |:|          ||         |:|....|| .::.:|.:...|.:.   .||       |.:
Zfish  1034 DTIIDSFLREKPRSI---------SVDLLFETSAFKEPDSHELSADHIQDFDTEP-------KDL 1082

  Fly  1008 KE-KRLEMEKKLESL---RKKHDKE--------------------------------KIKIAGQK 1036
            || ..|.:|....||   :|:|.::                                .::..|::
Zfish  1083 KETPYLVIEGSKNSLSDPQKEHSRDFGKSFTEGDKLCSSKRPADHWSGPSDQCNGGSIVQSEGRE 1147

  Fly  1037 SSPLEGKKPKFAITNKLVKRLSNKSL-----NCLSPHSEPGVEIP--ACPLDLGDSS----EESA 1090
            .|.||..| |..:|.|.....|..|.     |....|| |.:::|  ...:.|.||:    .::.
Zfish  1148 CSQLESDK-KNLLTTKAATYSSTSSSSYSSGNLTKSHS-PKMDLPDQNSQMSLQDSALSRLIDAV 1210

  Fly  1091 AADAGEDLAGGSSSLDGR-----TQESRLRSACREYTSQYRELQ--------EKYHEAIYSAAEK 1142
            :.:...|..|..|:|.|:     .|.:::.|..:.....:..|.        :...:::|:|::.
Zfish  1211 SLENEYDTCGSISALIGQFELTAQQNTQIISDSQSMKHSHSHLSNGLSSTPLKLTEKSVYTASDP 1275

  Fly  1143 VLKTSQTGQTK-QLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERG 1206
            .:::|....|: .:...||:   ||:..:  :..:..:||..               .||:|.:|
Zfish  1276 TMRSSSPETTEPAVFTILDE---EVLSPV--STNSFCQNLPN---------------ESSMVSQG 1320

  Fly  1207 VAE-RVRLKQTFDRRTDELQKQH----DSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLFH 1266
            .:. :..|:.|..|...|.....    ||.:|  .:.|......::..|..|       ||:
Zfish  1321 SSPIKKPLEWTAQRNPKESSSSQSPSTDSFKN--FDFRGYRETSINSTASDR-------FLM--- 1373

  Fly  1267 GPHHHGCTGSGSSALSGNNLTLNLD 1291
                  |..|.||:|.  .|.:|:|
Zfish  1374 ------CQDSVSSSLM--ELEINVD 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	25/136 (18%)
		EFh_PI-PLC21	151..305	CDD:320043	37/169 (22%)
		EF-hand motif	151..180	CDD:320043	6/32 (19%)
		EF-hand motif	187..216	CDD:320043	10/40 (25%)
		EF-hand motif	225..255	CDD:320043	5/29 (17%)
		EF-hand motif	272..305	CDD:320043	9/32 (28%)
		PI-PLCc_beta	317..702	CDD:176533	149/431 (35%)
		C2_PLC_like	736..855	CDD:175974	42/131 (32%)
		PTZ00121	<981..>1253	CDD:173412	62/340 (18%)
plch1	XP_073786090.1	None