DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plcd3b

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_005156186.1 Gene:plcd3b / 562569 ZFINID:ZDB-GENE-081222-2 Length:769 Species:Danio rerio


Alignment Length:816 Identity:264/816 - (32%)
Similarity:366/816 - (44%) Gaps:187/816 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 TIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTD 130
            |:|:    |.|..|::..| .||..|.:.:|:.:                   |...:.||.|..
Zfish    96 TLRN----QAASLPEEQCL-TIVFKGGRKSLDVQ-------------------CDTTEEAQHWVH 136

  Fly   131 GLIKL---AYSLAQ---LNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFA-----QNKEDRK 184
            |:..|   ..::.|   |:.....:|::|      .::..|::..:.:..||.     .|:|...
Zfish   137 GIRTLQGRVNNMTQKEKLDNWIYGYLKQA------DINHDGKMSYEEVQVLFKLVNIDLNEEYAA 195

  Fly   185 RVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKC-MSIAQLV 248
            .:.|          |.|..:..:.:.|:.....:.|.:|.|::.:|.....|.   | :|...|.
Zfish   196 SLFK----------KSDKSADGRLEHEEIELFCRELLRRPELDAVFQQYSANG---CVLSTVDLR 247

  Fly   249 EFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQ-LSLDGFLRYLMGDDNPIMAPS 312
            |||.....|..|          ..|:.||..||.|:: |||.| ::.:||..|::..:|.:..|.
Zfish   248 EFLKDQGEDHTL----------VHAQSLILTYELNEW-AQKNQFMTANGFTMYMLSKENDVYNPD 301

  Fly   313 KLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIV 377
            ...:..||..|:|||||:||||||||..||...|||..|.:.|..||||||||.|:|. :||||.
Zfish   302 HRRVYQDMSHPLSHYFISSSHNTYLTKDQLISDSSVHPYIRALSQGCRCVELDCWDGE-KEPVIY 365

  Fly   378 HGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDS 442
            ||:|...::...||::.|||.||.||.||:|||.||||:..||..:|...|.|.||.||.|||:.
Zfish   366 HGHTLTSKVPFSDVVKIIAEYAFTTSPYPLILSLENHCSVEQQTIMAQQLRSILGDKLLSKPLND 430

  Fly   443 HPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQV 507
            .||:   .||.|..|:.||::|.||                                        
Zfish   431 KPLQ---YLPSPEDLKGKILMKAKK---------------------------------------- 452

  Fly   508 GLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLP 572
                                                   .::.|.|    .|||| |||:|||..
Zfish   453 ---------------------------------------IKVEQDS----SSSDS-SSSDDESKA 473

  Fly   573 NTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKK--NRCYEMSSFDEKQAT 635
            :.        :|.|||  ::.:..:|:|.||.|...:.|..|:.:.||  |   |||||.|..|.
Zfish   474 DC--------KPKPEK--RDCKLSSELSDLVVYTSSVAFKQFDPSAKKAPN---EMSSFSESDAL 525

  Fly   636 TLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFE 700
            .|:||....||.:|..||||:||:|.|..|||:.||..||||||:|||||||....|.||.|.|.
Zfish   526 KLIKESGKLFVRHNSVQLSRIYPSGQRVQSSNYNPQDMWNAGCQIVALNFQTQSEEMDLNRGRFL 590

  Fly   701 YNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKR-----ANTFVEV 758
            .|...||:|||.||.:.|...:|.......|.....::|.|:|.|.|  .||.     .:..|.|
Zfish   591 ANGNCGYVLKPSFMCQPDSEFNPENTGGGPGYNPTLLTIKVISAQQLPKPDKEKLSSIVDPLVWV 655

  Fly   759 DMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFK-KVVLPELASIRIAA----YEEGGKLIGH 818
            .:||.|.|...||  |..:.:||.||.:|   ..|| ::.:|||..||...    |......:|.
Zfish   656 QIYGAPIDNSTKK--THHINNNGFNPRWD---CTFKFQLHVPELVLIRFMVEDHDYTTRNDFLGQ 715

  Fly   819 RVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVV 854
            ..||...|..|||||.|.:..|..|:.:|||:.|.:
Zfish   716 FTLPFPSLRTGYRHVRLLNADGCSISPSSLFIHVKI 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 18/84 (21%)
EFh_PI-PLC21 151..305 CDD:320043 36/160 (23%)
EF-hand motif 151..180 CDD:320043 4/33 (12%)
EF-hand motif 187..216 CDD:320043 4/28 (14%)
EF-hand motif 225..255 CDD:320043 9/30 (30%)
EF-hand motif 272..305 CDD:320043 13/33 (39%)
PI-PLCc_beta 317..702 CDD:176533 151/386 (39%)
C2_PLC_like 736..855 CDD:175974 45/131 (34%)
PTZ00121 <981..>1253 CDD:173412
plcd3bXP_005156186.1 PH-like 34..152 CDD:473070 17/79 (22%)
EFh_PI-PLC 157..294 CDD:333715 37/166 (22%)
EF-hand motif 157..186 CDD:320029 5/34 (15%)
EF-hand motif 193..221 CDD:320029 4/37 (11%)
EF-hand motif 226..254 CDD:320029 9/30 (30%)
EF-hand motif 261..294 CDD:320029 13/33 (39%)
PI-PLCc_GDPD_SF 306..592 CDD:472694 151/386 (39%)
C2_PLC_like 624..752 CDD:175974 45/133 (34%)
Blue background indicates that the domain is not in the aligned region.

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