DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plcd1a

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001103170.1 Gene:plcd1a / 555443 ZFINID:ZDB-GENE-071004-78 Length:775 Species:Danio rerio


Alignment Length:829 Identity:264/829 - (31%)
Similarity:385/829 - (46%) Gaps:177/829 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 DIATIRDVRTG-------QYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCT 120
            ::|.|..||.|       :|.....:|:...|:..|.::.|:     :...||            
Zfish    88 ELAEIDSVRLGRQSEGLQKYTYSSIENRCFSIIFKGRRENLD-----LIASSD------------ 135

  Fly   121 RRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKL--CL-QVDKSGRIPVKNIIKLFAQNKED 182
              |.|..|.:.|.|:...|.:||..     |.:...:  |: :.||:            |.||..
Zfish   136 --DEANCWVNSLEKVINRLHKLNRQ-----QNSEHWIYECMRKADKN------------ADNKMS 181

  Fly   183 RKRVEKALDVTGLPSGKVDSISVSKFQFED--------------FYNLYKYLTQRSEVERLFDSI 233
            .|.::..|....:...  ||.:.:.|:..|              ||||   ||||.|::.::|..
Zfish   182 LKELKHFLRQINIEVN--DSYAETLFRKCDTSNSGTLEGSEIKLFYNL---LTQRDEIDVIYDKY 241

  Fly   234 VGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFL 298
            ..::.:  ||...|:.|:...||:|         .:...|:|||::||.::...|...:|.||||
Zfish   242 ATSNGQ--MSRNDLLNFIQLEQREP---------VSLGYAEELIKKYEVDETAKQDKHMSKDGFL 295

  Fly   299 RYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVE 363
            .|| ..:..::.|:.:|:..||.||::||||:|||||||...||.|.||.|.|.:.|:..|||||
Zfish   296 MYL-NQEGTLLNPAHIDVYQDMQQPLNHYFISSSHNTYLMEDQLKGPSSTEAYIKALMKSCRCVE 359

  Fly   364 LDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCR 428
            ||.|:|...||||.:|:|...::..|||::||.:.|||.|.||||||.||||:..||..:|.:..
Zfish   360 LDIWDGANGEPVIYYGHTLTSKVPFKDVIKAIKDYAFKASPYPVILSLENHCSLEQQKIVAMHLT 424

  Fly   429 EIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKL 493
            .|.|..||.:||..   :.....|.|..|:.:.:||.|:.         :|..|     |.||  
Zfish   425 TILGSALLTQPLGQ---KMPTTFPGPEDLKGRFLIKGKRL---------NKLDA-----AFNN-- 470

  Fly   494 TTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTG 558
            .||..|:         |.|.||                          .|..|::...:.|||  
Zfish   471 NTAEDVE---------SVSEED--------------------------EAADLKEGEPTHKDS-- 498

  Fly   559 SSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRC 623
                                         |..|:.:...|:|.||.|.:.:||:|||.:.||...
Zfish   499 -----------------------------KKSKKIKLAKELSDLVVYCKSVHFTSFEQSRKKQAF 534

  Fly   624 YEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTL 688
            |||:||.|.:|..|.::....|:.:|..:|||:||||:|.||||:.|...||||||:|||||.|.
Zfish   535 YEMASFKEGKAMNLAEQSANAFIRHNIDKLSRIYPAGSRTDSSNYNPVPLWNAGCQIVALNFLTP 599

  Fly   689 DLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN 753
            ...|.||...|..|.:|||:|||||:|....:.||........:....:.|.|:|.|.|.....|
Zfish   600 CKEMDLNQARFLPNGKSGYILKPEFLRDPASQFDPINLRKGPWLQKKVLHIMVISAQQLPKINKN 664

  Fly   754 -------TFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIR--IAAY 809
                   ..|.|::||:|.|...|  :|..:.:||.||:::.. |.| .|.:||||.:|  :..|
Zfish   665 KEKSIVDPHVRVEIYGVPQDNASK--QTHHIDNNGFNPMWNTN-FQF-TVNVPELALVRFVVEDY 725

  Fly   810 EEGGK--LIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            :...|  |||...:|:..:..||||:.|.::.|..|..|.||:.|::.|
Zfish   726 DAASKNDLIGLYTIPLTSMQNGYRHMPLLTKRGIIIPSAGLFVHVMLLD 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 20/88 (23%)
EFh_PI-PLC21 151..305 CDD:320043 44/170 (26%)
EF-hand motif 151..180 CDD:320043 5/31 (16%)
EF-hand motif 187..216 CDD:320043 7/42 (17%)
EF-hand motif 225..255 CDD:320043 6/29 (21%)
EF-hand motif 272..305 CDD:320043 14/32 (44%)
PI-PLCc_beta 317..702 CDD:176533 142/384 (37%)
C2_PLC_like 736..855 CDD:175974 43/129 (33%)
PTZ00121 <981..>1253 CDD:173412
plcd1aNP_001103170.1 PH_PLC_delta 44..159 CDD:270169 20/94 (21%)
EFh_PI-PLCdelta1 164..302 CDD:320047 43/166 (26%)
EF-hand motif 164..193 CDD:320047 8/40 (20%)
EF-hand motif 200..229 CDD:320047 6/31 (19%)
EF-hand motif 233..264 CDD:320047 8/32 (25%)
EF-hand motif 269..302 CDD:320047 14/33 (42%)
PI-PLCc_delta 313..613 CDD:176535 142/384 (37%)
C2_PLC_like 645..770 CDD:175974 42/128 (33%)
Blue background indicates that the domain is not in the aligned region.

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