DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and PLCG1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_005260495.1 Gene:PLCG1 / 5335 HGNCID:9065 Length:1330 Species:Homo sapiens


Alignment Length:1262 Identity:287/1262 - (22%)
Similarity:424/1262 - (33%) Gaps:527/1262 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LDIATIRDVRTGQYAKRPKD-NKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIA 125
            :||..|:::|.|   |..:| ::.::.....|.   :.....:.:|.:| .:..::...|..|..
Human    73 IDIREIKEIRPG---KTSRDFDRYQEDPAFRPD---QSHCFVILYGMEF-RLKTLSLQATSEDEV 130

  Fly   126 QLWTDGLI--------------------KLAYS-----------------LAQLNGSA--IMFLQ 151
            .:|..||.                    |..||                 |:|:|...  :.||:
Human   131 NMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLR 195

  Fly   152 KAHTKLCLQVDKSGRIPVKNIIKLF------AQNKEDRKRVEKALDVTGLPSG-KVDSISVSKFQ 209
            :..|.|   ..:||.|......:|:      ||...|.    ..|:.:.|.:| :.:...||..:
Human   196 ERLTDL---EQRSGDITYGQFAQLYRSLMYSAQKTMDL----PFLEASTLRAGERPELCRVSLPE 253

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            |:.|  |..|..:...|:||                |:.||:....||| |.||..||       
Human   254 FQQF--LLDYQGELWAVDRL----------------QVQEFMLSFLRDP-LREIEEPY------- 292

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLD-LC-DDMDQPMSHYFINSSHNTYL 337
                             ..||.|:.:|...:|.:. .|:|| :| |.|:.|:|||:|:|||||||
Human   293 -----------------FFLDEFVTFLFSKENSVW-NSQLDAVCPDTMNNPLSHYWISSSHNTYL 339

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ||.|.:.:||:|.|.:||..||||:|||.|:|....|||.||:|...:|...|||..|.|.||..
Human   340 TGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVA 404

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD-LPPPAMLRRKIIIKNK 466
            ||||||||.|:||:..||..:|.|.:::.||.||.|     |:|.:.| ||.|..|:|||:||:|
Human   405 SEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTK-----PVEISADGLPSPNQLKRKILIKHK 464

  Fly   467 K------------------------------------KHHHHHHH-------------------- 475
            |                                    .|..:.|:                    
Human   465 KLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGN 529

  Fly   476 HHHKKPAQV----------------------GTPAANNKLT------------------------ 494
            ...::|.:|                      |...|...||                        
Human   530 EDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGD 594

  Fly   495 --------------------------------------------------TANSVDAKAAQQVGL 509
                                                              ..|..:.:.::.|..
Human   595 YTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQ 659

  Fly   510 SASHED-----GGVTRSTANGDVATGTGTGS-----------------AAGTAGHAPPLQQ---- 548
            :.:||.     ..:||:.|...:......|:                 |.|...|....|:    
Human   660 TNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTV 724

  Fly   549 -------------------------------IRQSSKDSTGSSDSD------------------- 563
                                           |.:.:.:..|:::.|                   
Human   725 MLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPM 789

  Fly   564 --------------SSSEDE--------------------------------------------- 569
                          :..|||                                             
Human   790 PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVA 854

  Fly   570 ---SLPNTTPNLPSGN------EPP-------PE-------------------------KAQKE- 592
               ...:...|.|.|:      :.|       ||                         .:|:| 
Human   855 LEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEEL 919

  Fly   593 ------------------TEA---------GAEISALVNYVQPIHFSSFENAEKKNRCY-EMSSF 629
                              ||.         ..|:|.||.|.:|:.|.. |....:..|| :||||
Human   920 QDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSF 983

  Fly   630 DEKQATTLL-KERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQ 693
            .|.:|...: |.:..:|:.||:.||||:||.|.|.||||:.|...|..|.|||||||||.|..||
Human   984 PETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQ 1048

  Fly   694 LNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRAN---TF 755
            :|..:|......||:|:|..||  |...|||.:|::.|:....:||.||..:.|......   .|
Human  1049 MNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPF 1111

  Fly   756 VEVDMYGLPADTVRKK-------------------------------------FRTKTVRDNGMN 783
            ||:::.|...|:.::|                                     |......|||:|
Human  1112 VEIEVAGAEYDSTKQKTEFVGQSVFPVILLILLGHCKPLPTSHPILSHGDLKPFVVAFTVDNGLN 1176

  Fly   784 PLYDEEPFVFKKVVLPELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIA 844
            |::..:||.| ::..||.|.:|...|||    ....:.....||.||..|||.|.|::...:.:.
Human  1177 PVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLE 1240

  Fly   845 LASLFLCVVVKDYVP-----DDLSNFA 866
            ||||.:.:   |..|     .|||.|:
Human  1241 LASLLIKI---DIFPAKQENGDLSPFS 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 21/120 (18%)
EFh_PI-PLC21 151..305 CDD:320043 36/160 (23%)
EF-hand motif 151..180 CDD:320043 8/34 (24%)
EF-hand motif 187..216 CDD:320043 7/29 (24%)
EF-hand motif 225..255 CDD:320043 6/29 (21%)
EF-hand motif 272..305 CDD:320043 4/32 (13%)
PI-PLCc_beta 317..702 CDD:176533 166/744 (22%)
C2_PLC_like 736..855 CDD:175974 40/162 (25%)
PTZ00121 <981..>1253 CDD:173412
PLCG1XP_005260495.1 PH_PLC_gamma 29..151 CDD:270168 15/84 (18%)
EFh_PI-PLCgamma1 156..306 CDD:320044 44/199 (22%)
EF-hand motif 156..185 CDD:320044 5/28 (18%)
EF-hand motif 193..221 CDD:320044 8/30 (27%)
EF-hand motif 226..262 CDD:320044 9/41 (22%)
EF-hand motif 272..306 CDD:320044 15/58 (26%)
PI-PLCc_gamma 319..>466 CDD:176534 79/151 (52%)
PH-like 489..>523 CDD:473070 2/33 (6%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 5/103 (5%)
SH2_C-SH2_PLC_gamma_like 663..765 CDD:198186 11/101 (11%)
SH3_PLCgamma1 791..850 CDD:212903 3/58 (5%)
PHsplit_PLC_gamma <864..933 CDD:270054 8/68 (12%)
PLCYc 954..1069 CDD:128454 52/115 (45%)
C2_PLC_like 1087..1250 CDD:175974 40/166 (24%)
Blue background indicates that the domain is not in the aligned region.

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