DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and PLCB4

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001364071.1 Gene:PLCB4 / 5332 HGNCID:9059 Length:1206 Species:Homo sapiens


Alignment Length:1310 Identity:490/1310 - (37%)
Similarity:700/1310 - (53%) Gaps:220/1310 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EVPQALQDGEKFIRWDDDSGTGTP-VTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKR 78
            |||..||:|..|.|::::|....| ...:||..||||.|..:..|..:|:.:.|..:|:|...|.
Human    12 EVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKD 76

  Fly    79 PKDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQL 142
            ||  .|..:..:| .::.||.:.|.||.|:|.||::|........::.:.|.:||..:.::....
Human    77 PK--ILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRAN 139

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            |.|.:..|:|...||....:.:|:|||::|.:.||..|.: |.:.:||...||||||.|.|..:.
Human   140 NVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTE-KVIFQALKELGLPSGKNDEIEPTA 203

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPAR 272
            |.:|.||.|.:.:..|:::|.||..|.|: |...:::.|||.|||:.||||||||||:|:.:..|
Human   204 FSYEKFYELTQKICPRTDIEDLFKKINGD-KTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKR 267

  Fly   273 AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYL 337
            |.::|:.|||::...:||.:|.|||.||||.|:|..:...:|:|..:||.|::||||:|||||||
Human   268 AMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYL 332

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--EPVIVHGYTFVPEIFAKDVLEAIAESAF 400
            ||.|..||||||:|||.|||||||||||.|:|:.|  ||:|.||.....:|..|||::||.|:||
Human   333 TGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAF 397

  Fly   401 KTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKN 465
            .||||||||||||||:..||.|::.||.::|||:||.:.|:||||||...||.|..|:|||:|||
Human   398 VTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKN 462

  Fly   466 KKKHHHHHHHHHHKKP----------------AQVGTPAANNKLTTANSVDAKAAQQ-------- 506
            |:           .||                .:..:||  |.|...|..:.::|.|        
Human   463 KR-----------LKPEVEKKQLEALRSMMEAGESASPA--NILEDDNEEEIESADQEEEAHPEF 514

  Fly   507 -VGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDS--SSED 568
             .|...|.:|.|...:.||                       .::::|.|....::...  :.||
Human   515 KFGNELSADDLGHKEAVAN-----------------------SVKKASDDLEHENNKKGLVTVED 556

  Fly   569 E-----------SLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNR 622
            |           :..|..|.|                     |.::||.||:.|..|..||::|.
Human   557 EQAWMASYKYVGATTNIHPYL---------------------STMINYAQPVKFQGFHVAEERNI 600

  Fly   623 CYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQT 687
            .|.||||:|......||...||||||||.|:||:||.|.|.||||:|||:|||||||:|:||:||
Human   601 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQT 665

  Fly   688 LDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRA 752
            .|||||||.|.||||...||||||:||||.||..|||:|:.|||:||.|.|:.|:|||||:||:.
Human   666 PDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKI 730

  Fly   753 NTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIG 817
            .|:|||||||||.||:||:|||:.|.:||:||:|:||.|||:||:||:||.:|||.|::..||||
Human   731 GTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIG 795

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKR 882
            .|:||:.||..||||::||:|..:|::|.::|..:|:|.||||...:..:||::|.|:.|..|||
Human   796 QRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKR 860

  Fly   883 DIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTV 947
            ..|:..:..|...:.....|.||:....:....|..:.|    .:|.:.||:.:||.|..|:   
Human   861 ADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTP----QSSSELRPTTTAALASGVE--- 918

  Fly   948 DRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKE--K 1010
                                                  ::..::|:   |..:|.|.|.:|.  |
Human   919 --------------------------------------AKKGIELI---PQVRIEDLKQMKAYLK 942

  Fly  1011 RL-EMEKKLESLRKKHDKE-----KI------KIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLN 1063
            .| :.:|:|.||:|||.||     |:      ||..|..   :.|.....|..|.:|:....  |
Human   943 HLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYD---KEKSTHEKILEKAMKKKGGS--N 1002

  Fly  1064 CLSPHSEPGVEIPACPLDLGDSSEESAAADAGE--DLAGGSSSLDGRTQESRLRSACREYTSQYR 1126
            ||....|..::|.....|.....:|..|....|  ::....|:     :|..:|..   :.||..
Human  1003 CLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSA-----EEQEIRDL---HLSQQC 1059

  Fly  1127 ELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEV-MHQLQEARRN--------EVKNLA 1182
            ||           .:|:|..:...||:|||.|.|:.:.|: .||.:.:..|        .:||.|
Human  1060 EL-----------LKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKA 1113

  Fly  1183 TVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILD 1247
                   |..|..||:.||..::.:.||.||.....:..|:|:|       ...||    .:.|:
Human  1114 -------ERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKK-------VQLEH----LEFLE 1160

  Fly  1248 KEAES--RSC 1255
            |:.|.  :||
Human  1161 KQNEQLLKSC 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 38/126 (30%)
EFh_PI-PLC21 151..305 CDD:320043 67/153 (44%)
EF-hand motif 151..180 CDD:320043 10/28 (36%)
EF-hand motif 187..216 CDD:320043 14/28 (50%)
EF-hand motif 225..255 CDD:320043 12/29 (41%)
EF-hand motif 272..305 CDD:320043 16/32 (50%)
PI-PLCc_beta 317..702 CDD:176533 181/424 (43%)
C2_PLC_like 736..855 CDD:175974 68/118 (58%)
PTZ00121 <981..>1253 CDD:173412 75/298 (25%)
PLCB4NP_001364071.1 PH_PLC_beta 17..143 CDD:270167 38/127 (30%)
EFh_PI-PLCbeta4 148..300 CDD:320041 67/153 (44%)
EF-hand motif 148..177 CDD:320041 10/28 (36%)
EF-hand motif 183..212 CDD:320041 14/28 (50%)
EF-hand motif 221..250 CDD:320041 12/29 (41%)
EF-hand motif 267..300 CDD:320041 16/32 (50%)
PI-PLCc_beta 312..680 CDD:176533 181/424 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..511 7/30 (23%)
C2_PLC_like 714..830 CDD:175974 67/115 (58%)
PTZ00121 <859..1206 CDD:173412 93/402 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..907 6/35 (17%)
DUF1154 925..967 CDD:461969 17/44 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1094..1122 7/34 (21%)

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