DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and PLCB3

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_000923.1 Gene:PLCB3 / 5331 HGNCID:9056 Length:1234 Species:Homo sapiens


Alignment Length:1319 Identity:532/1319 - (40%)
Similarity:740/1319 - (56%) Gaps:155/1319 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPK 80
            |.:.|:.|.|||:||:::.:...||:|||..||||||...|.|:|.|||::|||.|||:||:.||
Human    18 VVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPK 82

  Fly    81 DNKLRQIVTL-GPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNG 144
            |.|:|:::.. ||...||||.:||..|.|.||..|:||...:.|.|::|::.|.|||.::...|.
Human    83 DPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNA 147

  Fly   145 SAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQ 209
            |...||:||:|||.|||::.||||||||:|:|:   .|:||||.||:..||...:.:||...:|.
Human   148 SRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS---ADKKRVETALESCGLKFNRSESIRPDEFS 209

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            .|.|......|..|.:::::...| |...:..:::.||::|:|:.||||||||:|||...|::|:
Human   210 LEIFERFLNKLCLRPDIDKILLEI-GAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQAR 273

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTG 339
            .||::||||:...::.|:|::||.|||.|::|.|:....|||..||.||:|.||||||||||||.
Human   274 LLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTA 338

  Fly   340 HQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            .||.|.||||:|||.||.||||||||.|.||  .|||.|.||:|...|:..:||||||||:||||
Human   339 GQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKT 403

  Fly   403 SEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNK 466
            |.||||||||||. :.:||||:|.|||.||||.||.:|||.:||.|.:.||.|..|..:|::|||
Human   404 SPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNK 468

  Fly   467 KKHHHHHHHHHHKKPAQVGTPAANNK--LTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVAT 529
            |:|          :|:..|..:|..|  |..:||..:::      ||:.|.......:.:.|...
Human   469 KRH----------RPSAGGPDSAGRKRPLEQSNSALSES------SAATEPSSPQLGSPSSDSCP 517

  Fly   530 GTGTGSAAGTAGHAPPLQQIRQSSKDS-------TGSSDSDSSSED-ESLPNTTPNLPSGNEPPP 586
            |...|...|.  ..|.|:..:....:.       .|.:|.:...|| |....|.|..|:.:|   
Human   518 GLSNGEEVGL--EKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDE--- 577

  Fly   587 EKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKH 651
            ..|..|..|..|:|.||||::|:.|.|||.|.|:|:|:|||||.|.:|...|.:.|:|||.|||.
Human   578 GTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQ 642

  Fly   652 QLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRR 716
            ||||:||.|||.||||:|||||||.|||||||||||||:|||||.|:||||.|||||||||||||
Human   643 QLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRR 707

  Fly   717 SDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNG 781
            .|:..|||.|..||||:|..:.:.|:|||||:|::...:|||||:|||.|| |:|:||:|.:.|.
Human   708 PDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNS 771

  Fly   782 MNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALA 846
            .||::|||||.|.|||||.|||:||||:|||||.:|||:|||..:..||.:|.||:|..||:.|.
Human   772 FNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLP 836

  Fly   847 SLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQ 911
            :|.:.....||:|||..::||||.||||:.|.:::|..||:.|..|:||  .|.::..:.....|
Human   837 ALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEA--QAGQETCQDTQSQQ 899

  Fly   912 VGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSV 976
            :|.|.........|..||:..|..:.:.|                 |.|:.:|.     ..|..:
Human   900 LGSQPSSNPTPSPLDASPRRPPGPTTSPA-----------------STSLSSPG-----QRDDLI 942

  Fly   977 STSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLE 1041
            ::.:.:|..:          ||:::..||::.:.|...|:.|..|||||.::.:           
Human   943 ASILSEVAPT----------PLDELRGHKALVKLRSRQERDLRELRKKHQRKAV----------- 986

  Fly  1042 GKKPKFAITNKLVKRLSNKSL--NC-LSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSS 1103
                  .:|.:|:..|:....  .| |.|.:..|.      .|:.|:.|       |||.|....
Human   987 ------TLTRRLLDGLAQAQAEGRCRLRPGALGGA------ADVEDTKE-------GEDEAKRYQ 1032

  Fly  1104 SLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMH 1168
            ....|..:|.|.....:..::.:...|...:|:....|.||..:.| |.|:||...::...|:..
Human  1033 EFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTT-QFKRLKEMNEREKKELQK 1096

  Fly  1169 QLQEARRNEVK--NLATVHRDRDELIRMKREVASSVVERGVAERV----RLKQTFDRRTDELQKQ 1227
            .|...|.|.:.  .:...|:...||..:.|        |.:.|.|    ||::...:|.|.|...
Human  1097 ILDRKRHNSISEAKMRDKHKKEAELTEINR--------RHITESVNSIRRLEEAQKQRHDRLVAG 1153

  Fly  1228 HDSVRNALAEHRSKARQILDKEAESR--------------------------SCVSSNGFLVLFH 1266
            ...|...|||...|....|.:|.:.:                          :| :|||     |
Human  1154 QQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVAC-ASNG-----H 1212

  Fly  1267 GPHHHG-CTGSGSSALSGN 1284
            .|...| .:|:.|.:...|
Human  1213 APGSSGHLSGADSESQEEN 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 60/125 (48%)
EFh_PI-PLC21 151..305 CDD:320043 67/153 (44%)
EF-hand motif 151..180 CDD:320043 18/28 (64%)
EF-hand motif 187..216 CDD:320043 10/28 (36%)
EF-hand motif 225..255 CDD:320043 6/29 (21%)
EF-hand motif 272..305 CDD:320043 15/32 (47%)
PI-PLCc_beta 317..702 CDD:176533 200/397 (50%)
C2_PLC_like 736..855 CDD:175974 64/118 (54%)
PTZ00121 <981..>1253 CDD:173412 63/280 (23%)
PLCB3NP_000923.1 PH_PLC_beta 22..149 CDD:270167 60/126 (48%)
EFh_PI-PLCbeta3 154..304 CDD:320040 67/153 (44%)
EF-hand motif 154..183 CDD:320040 18/31 (58%)
EF-hand motif 187..216 CDD:320040 10/28 (36%)
EF-hand motif 225..254 CDD:320040 6/29 (21%)
EF-hand motif 271..304 CDD:320040 15/32 (47%)
PI-PLCc_beta3 316..693 CDD:176562 200/397 (50%)
PLN02952 <318..833 CDD:178538 286/536 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..587 31/140 (22%)
PRK06975 <873..>1066 CDD:235899 51/256 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..937 12/71 (17%)
DUF1154 951..990 CDD:461969 12/65 (18%)
PLC-beta_C 1029..1202 CDD:462571 36/181 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1198..1234 10/40 (25%)
Interaction with SHANK2. /evidence=ECO:0000250 1231..1234 1/1 (100%)

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