DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and PLCB2

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_016877803.1 Gene:PLCB2 / 5330 HGNCID:9055 Length:1205 Species:Homo sapiens


Alignment Length:1305 Identity:475/1305 - (36%)
Similarity:704/1305 - (53%) Gaps:213/1305 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRP 79
            :|...|..||:||:|||::...:||.:|||.||::|||..|:.|::.|||.:|||.|.|::||.|
Human    12 KVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMP 76

  Fly    80 KDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
            |..|||.:..:. |.::...||:||..|.|.|::||.||...:.::.:.|.:.::.|.......|
Human    77 KSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTAN 141

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKF 208
            .|...||.|...||.:|::..|:|||||..::|   ..||||||.||....||.||.|:|:...|
Human   142 ASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMF---PADRKRVEAALSACHLPKGKNDAINPEDF 203

  Fly   209 QFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARA 273
            ....:.:....|..|.|::.:|.|....:| ..|:...|.:|:|:.|||.|||.:|:|.|.|.:.
Human   204 PEPVYKSFLMSLCPRPEIDEIFTSYHAKAK-PYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQV 267

  Fly   274 KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            :.||.:|||:..|||:||||.:|.:.:|.|.:|.::|..||.|..||.||::|||||||||||||
Human   268 QGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLT 332

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESAFK 401
            ..|.:|.||.|:|||.||:||||||||.|.|:  .|||:|.||:|...:||.|:.:|||||||||
Human   333 AGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFK 397

  Fly   402 TSEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKN 465
            ||.||:|||||||. :||||||:|.|||.|||||||.:||:..||:|.:.||.|..||.||:|||
Human   398 TSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKN 462

  Fly   466 KKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATG 530
            ||.              |...|.                     |:|.:.||....::......|
Human   463 KKN--------------QFSGPT---------------------SSSKDTGGEAEGSSPPSAPAG 492

  Fly   531 TGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEA 595
            .|| ..||..|.....:::.:..::.:|:.|.:...:.:|...|              |..|..|
Human   493 EGT-VWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGT--------------AGLEVTA 542

  Fly   596 GAEISALVNYVQPIHFSSFE-------------NAEKKNRCYEMSSFDEKQATTLLKERPIEFVN 647
            ..|:|:||||:||..|.|||             :..||||.|.:|||.|.:|..||.:..::||:
Human   543 YEEMSSLVNYIQPTKFVSFEFSAPRLFTCIFSGHKHKKNRSYVISSFTELKAYDLLSKASVQFVD 607

  Fly   648 YNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPE 712
            |||.|:||:||.|||.||||:|||:|||||||:|||||||:||.||.|:.:||:|.:||||||.|
Human   608 YNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHE 672

  Fly   713 FMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTK-T 776
            ||||.|::.:||:...:|.::|.|:||||:|||||:::...|:|||:::|||.|. ::::||| :
Human   673 FMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDP-KRRYRTKLS 736

  Fly   777 VRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQ 841
            ...|.:||::.||||||:|:::|||||:|:|..|||.|.:|||::|:..|..||.|:.|.||...
Human   737 PSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNM 801

  Fly   842 PIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKS 906
            |:.:.:||:.:.:|||:|...::...|||||||:.|..:.:.::|.      ||:|...|   |.
Human   802 PLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLK------EAMGGLPE---KP 857

  Fly   907 F-----VFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSI 966
            |     |..||.|           |.:|....|.:|.|            |.|.|          
Human   858 FPLASPVASQVNG-----------ALAPTSNGSPAARA------------GAREE---------- 889

  Fly   967 QHQHSLDQSVSTSIRQVESSQFDVDLVLAEP----LEKILDHKSVKEKRLEMEKKLESLRKKHDK 1027
                        ::::.           |||    ||::.:.|.|.:.:...||:|..|.::..:
Human   890 ------------AMKEA-----------AEPRTASLEELRELKGVVKLQRRHEKELRELERRGAR 931

  Fly  1028 EKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGV-EIPACPLDLGDSS----- 1086
            ...::..:.::.|....|                         ||| .:.||.|..|..|     
Human   932 RWEELLQRGAAQLAELGP-------------------------PGVGGVGACKLGPGKGSRKKRS 971

  Fly  1087 ---EESAAADAGEDLAGGSSSLDGRTQESR-------LRSACREYTSQYRELQEKYHEAIYSAAE 1141
               ||||.|..||    |...:|||.:|.:       ||....:|....:..::...|.| |...
Human   972 LPREESAGAAPGE----GPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQI-SKMM 1031

  Fly  1142 KVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERG 1206
            ::.:..|..:.|.||.:.:..|.|:..:|:..|...::.:..|..|:....|:|||:.:|.::..
Human  1032 ELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEV 1096

  Fly  1207 VAERVRLKQTFDRRTDELQKQH----DSVR---------------NALAEHRSKARQILDKEAES 1252
            |....::.:..:|..::|:::.    :.:|               .||||:.::.:.:..:..||
Human  1097 VQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQGSLLSPQFQKEALAEYEARMKGLEAEVKES 1161

  Fly  1253 -RSCV 1256
             |:|:
Human  1162 VRACL 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 50/125 (40%)
EFh_PI-PLC21 151..305 CDD:320043 61/153 (40%)
EF-hand motif 151..180 CDD:320043 11/28 (39%)
EF-hand motif 187..216 CDD:320043 10/28 (36%)
EF-hand motif 225..255 CDD:320043 8/29 (28%)
EF-hand motif 272..305 CDD:320043 15/32 (47%)
PI-PLCc_beta 317..702 CDD:176533 185/400 (46%)
C2_PLC_like 736..855 CDD:175974 56/119 (47%)
PTZ00121 <981..>1253 CDD:173412 64/311 (21%)
PLCB2XP_016877803.1 PH_14 12..141 CDD:465506 50/128 (39%)
EFh_PI-PLCbeta2 149..299 CDD:320039 61/153 (40%)
EF-hand motif 149..178 CDD:320039 11/31 (35%)
EF-hand motif 182..211 CDD:320039 10/28 (36%)
EF-hand motif 220..249 CDD:320039 8/29 (28%)
EF-hand motif 266..299 CDD:320039 15/32 (47%)
PI-PLCc_beta2 311..662 CDD:176561 185/400 (46%)
C2_PLC_like 694..815 CDD:175974 57/121 (47%)
YhaN 892..>1087 CDD:443752 51/235 (22%)
PLC-beta_C 991..1173 CDD:462571 36/177 (20%)

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