Protein Alignment Plc21C and plcb4b

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_073789951.1
• Gene: plcb4b / 407700
• ZFINID: ZDB-GENE-060627-1
• Length: 1260
• Species: Danio rerio
• Alignment Length: 1351
• Identity: 497/1351 - (36%)
• Similarity: 702/1351 - (51%)
• Gaps: 170/1351 - (12%)

  Fly     3 SAGGTYISTASVE------VPQALQDGEKFIRWDDDSGTGTPVTM-RVDAKGFFLYWVDQNNELD 60
            :||...:.|.|.|      :|..||:|..|.|:|:|.....|..: :||..||||.|.....|..
Zfish    34 AAGLRAVMTKSYEFNWQKHIPDFLQEGAAFDRFDEDPFLFEPSCLFKVDEFGFFLTWKSDGKEGQ 98

  Fly    61 ILDIATIRDVRTGQYAKRPKDNK-LRQIVTLGPQDT-LEEKTVTVCHGSDFVNMTFVNFCCTRRD 123
            :|:.:.|..||.   |...||:| |..:...|..:. |:.:.:.||.|.|.||::|:.......|
Zfish    99 LLECSLINSVRP---AVVSKDSKILACLEAAGRSEADLDGRIICVCSGPDLVNLSFMYMVTDNTD 160

  Fly   124 IAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEK 188
            .|:.|.:||..:.::....|...:..|:|...:|....:.:|:|||:.|.:.|...|.: |.:.:
Zfish   161 TAKKWMEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTE-KGIFQ 224

  Fly   189 ALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNK 253
            ||...||||||.|.|..|.|.|:.||.|.:.:..|:::|.||..|.|: |...:::.|||.|||:
Zfish   225 ALKELGLPSGKNDEIEHSAFTFDIFYALTQKICPRTDIEELFKKINGD-KSDYLTVEQLVSFLNE 288

  Fly   254 TQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCD 318
            .||||||||||:|:....|..::|::||.:....:||::|.|||.||||.|:|..:...:||||.
Zfish   289 NQRDPRLNEILFPFYEAKRVTQIIEKYERDAELKKKGRMSSDGFCRYLMSDENAPVFLDRLDLCQ 353

  Fly   319 DMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--EPVIVHGYT 381
            :|:.|:|||||:|||||||||.|..||||||:|||.||:||||||||.|:|:.|  ||:|.||..
Zfish   354 EMEHPLSHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKA 418

  Fly   382 FVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLE 446
            ...:|..|||::||.|:||.||||||||||||||...||.|:|.||.|||||:||.:||:..|||
Zfish   419 MCTDILFKDVIQAIRETAFVTSEYPVILSFENHCCKPQQYKMAKYCEEIFGDLLLKQPLEGFPLE 483

  Fly   447 PNMDLPPPAMLRRKIIIKNKK-----KHHHHHHHHHHKKPAQVGTPAA--NNKLTTANSVDAKAA 504
            ....||.|..|||||:||||:     :.........|.:..::..||.  .|:....:::|.|..
Zfish   484 AGQQLPSPNDLRRKILIKNKRLKPEVEQKQLESFKKHMEAGEISIPAGEDENEEDLDSALDGKEV 548

  Fly   505 ---------QQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSS 560
                     |.|.......|....|...:.| ||.....:....|........|....|....|.
Zfish   549 SSELKAGLLQCVSEDQDAPDSSFRRKITDDD-ATEISEVTEITDATDVSEASDIESKKKGVESSE 612

  Fly   561 DSDSSSE-------DESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAE 618
            |:|:..:       :.:..|..|.|                     ||:|||.||:.|.|||.||
Zfish   613 DADAEQQLIASYKYEGATTNIHPYL---------------------SAMVNYAQPVKFQSFEVAE 656

  Fly   619 KKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVAL 683
            ::|..:.||||:|......||...||||||||.|:||:||.|.|.||||:|||:|||||||:|:|
Zfish   657 ERNIHHNMSSFNESVGLGYLKTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSL 721

  Fly   684 NFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLT 748
            ||||.||.||||.|.||||...||||||:||||.||..|||:|:.|||:||.|.|:.|.|||||:
Zfish   722 NFQTPDLGMQLNQGKFEYNGACGYLLKPDFMRRGDRMFDPFSETPVDGVIAATCSVQVFSGQFLS 786

  Fly   749 DKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGG 813
            ||:..|:|||||||||.||:||:|||:.|.:||:||.|:||||||:||:||:||.:|||.:::..
Zfish   787 DKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPYYNEEPFVFRKVILPDLAVLRIAVFDDNS 851

  Fly   814 KLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSE 878
            ||||.|:||:.||..||||::||:|..:|::|.::|..:|:|.||||......:||::|.|:.:.
Zfish   852 KLIGQRLLPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLTI 916

  Fly   879 LEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSV 943
            .|||..|:..|..|...:.....:.|||....:|...|..:.|..|..|:..|
Zfish   917 AEKRADQMRALGIETSDIADVPNESSKSDKKSKVSQVKSSVTPQSSAETNNTH------------ 969

  Fly   944 DVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVK 1008
                :.|:..||:.|:                    :.||.             :|.:...|:..
Zfish   970 ----NNTNDTRGDHSV--------------------VNQVN-------------IEDLKQMKTFI 997

  Fly  1009 EKRLEMEKKLESLRKKHDKEKIKIAGQKSS-------PLEGKKPKFAITNKLVKRLSNK-SLNCL 1065
            :...:.:|:|.:|:|:|.||  ..|.|||.       ..:..|.|..:...|.|.:..: ..||.
Zfish   998 KLLKKQQKELNTLKKRHAKE--HNAMQKSHCTQVDKLVAQHDKEKNTLEKLLEKAIKKRGETNCS 1060

  Fly  1066 SPHSEPGVEIPACPLDLGDSSEESAAADAGE--DLAGGSSSLDGRTQESRLRSACREYTSQYREL 1128
            ....|..|:|.....|..:..::..|....|  ::..|.||     :|..|:..   :.:|..||
Zfish  1061 ELKKETAVKIETLTTDHKEKVKDMVAQHTKEWSEMLSGCSS-----EEQELKDT---HITQQSEL 1117

  Fly  1129 QEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIR 1193
            .::...::.......:|.....|:|::||:..|.:.|....:.:.:  .:||.|       |..|
Zfish  1118 LKRLMSSVQEQQTSQMKLIHERQSKEMKANQAKSSMENSKAISQDK--SIKNKA-------ERER 1173

  Fly  1194 MKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSS 1258
            ..||:.||..::.:.||.||.....:..::|||   |.|..| |...|..:.|.|...|::.
Zfish  1174 RVRELNSSNTKKFLEERKRLAMKQAKEMEQLQK---SQREQL-EKLEKFNEQLLKSHHSQTA--- 1231

  Fly  1259 NGFLVLFHGPHH--HGCTGSGSSALSGNNLTLNLDAGAAGSHSAISPAKSH 1307
                    |..|  .|..|.|.              ||...:|.:|.|..|
Zfish  1232 --------GQRHAEDGEAGGGH--------------GAPAGYSGVSSACLH 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	40/127 (31%)
		EFh_PI-PLC21	151..305	CDD:320043	64/153 (42%)
		EF-hand motif	151..180	CDD:320043	8/28 (29%)
		EF-hand motif	187..216	CDD:320043	15/28 (54%)
		EF-hand motif	225..255	CDD:320043	12/29 (41%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	185/409 (45%)
		C2_PLC_like	736..855	CDD:175974	68/118 (58%)
		PTZ00121	<981..>1253	CDD:173412	65/281 (23%)
plcb4b	XP_073789951.1	None