Protein Alignment Plc21C and Plch2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_008762618.2
• Gene: Plch2 / 313756
• RGDID: 1304675
• Length: 1570
• Species: Rattus norvegicus
• Alignment Length: 1435
• Identity: 345/1435 - (24%)
• Similarity: 552/1435 - (38%)
• Gaps: 434/1435 - (30%)

  Fly    19 ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVR 71
            |:|:|.:.::            :|..:||.. .|::|::           ||...:.|.:|::|.
  Rat   191 AMQEGTQMVK------------LRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVS 243

  Fly    72 TGQYAKRPKDNKLRQIVTLGPQDTLEEK-TVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL--- 132
            .|:.:         :|....|..:.:.. ..::.:||...::..|:   ...:.|:.|..||
  Rat   244 EGRQS---------EIFQRYPDSSFDPNCCFSIYYGSHRESLDLVS---PSSEEARTWVTGLRYL 296

  Fly   133 ---IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKS--GRIPVKNIIKLFAQNKEDRKRVEKALDV 192
               |....|||:...:...:|::...    :.||:  |.:.:..:::|..:           |:|
  Rat   297 MAGISDEDSLARRQRTRDQWLKQTFD----EADKNGDGSLSISEVLQLLHK-----------LNV 346

  Fly   193 TGLPSGKVDSI--------SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVE 249
             .||..:|..:        ......||:|...||.::.|.::..|.  :..::.:..:..:.|..
  Rat   347 -NLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM--LTYSNHKDHLDASDLQR 408

  Fly   250 FLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKL 314
            ||...|   :::.:..     ...:.:|:|:||...|..||.|.:|||..|.......|..|...
  Rat   409 FLEVEQ---KMSGVTL-----ESCQSIIEQFEPCLENKSKGVLGIDGFTNYTRSPAGDIFNPEHH 465

  Fly   315 DLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHG 379
            .:..||.||:|||||.|||||||.|.||..:|.|::|...|.|||||||:|.|:|...||::.||
  Rat   466 RVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHG 530

  Fly   380 YTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHP 444
            ||...:|..|||:|.|.:.||..:|||||||.||||:..||.|:|.|..:|.||.|   .|.|..
  Rat   531 YTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKL---DLSSVS 592

  Fly   445 LEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGL 509
            .|....||.|.||:.||::|.|            |.||.:...|...:::..:|.|
  Rat   593 GEDATMLPSPQMLKGKILVKGK------------KLPANISEDAEEGEVSDEDSAD--------- 636

  Fly   510 SASHEDGGVTRSTANGDVATG-------------------------------TGTGSAAGTAGHA 543
              ..||   .....|||.:|.                               ..|.|.:|..||.
  Rat   637 --EIED---DCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFTVSTLSPSGKLGHK 696

  Fly   544 PPLQQIRQSSKDSTGSSDSDSSSE-----------------------------DESLPNTTPNLP 579
            ...::.:..:::...|.:....|.                             ||||  .:|...
  Rat   697 AEAKKAQSKAEEDVESGEDTGVSRRNSRLLMSSFSKRKKKGSKIKKVASVEEGDESL--DSPGSQ 759

  Fly   580 SGNEPPPEKAQKETEAGAEISALVNYVQPI--HFSSFENAEKKNRCYEMSSFDEKQATTLLKERP 642
            |......:|..|.:.|   :|.||.|.:.:  |....|....    :::|||.|.:|..:|:::|
  Rat   760 SRGTARQKKTMKLSRA---LSDLVKYTKSVGTHDVEMEVVSS----WQVSSFSETKAHQILQQKP 817

  Fly   643 IEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGY 707
            .:::.:|:|||||:||:..|.||||:.||.|||||||:||||:|:....:|||...|..|...||
  Rat   818 AQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGY 882

  Fly   708 LLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR----------ANTFVEVDMYG 762
            :|||:.|.:.  ..:|.:|..:.|.:...:::.::|||.|...|          .:.||||::.|
  Rat   883 VLKPQCMCQG--VFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIG 945

  Fly   763 LPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVI 824
            ||.|.  .|.:|:.|.|||.||:: ||..|| .|.:||:|.:|...::.   |...||.|.|...
  Rat   946 LPVDC--SKEQTRVVDDNGFNPMW-EETLVF-TVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFS 1006

  Fly   825 GLCPGYRHV-----------------NLRSEVGQPIALASLFLCVVVKDYVPDDLSNFA------ 866
            .:.||||||                 ::..:|.|.:.|..|||    :...|..|.:.|
  Rat  1007 SMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFL----RGPKPGSLDSHAAGQPLP 1067

  Fly   867 ----------EALANPIKYQSELEKRDIQLSVLTDEAEALGSADE-------------------- 901
                      ...:.|.|.|....|...:|::.|.:|.:.|:||:
  Rat  1068 RPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPPSPNPALEAPTQERSGS 1132

  Fly   902 ----------------------------------------------------------------- 901
                                                                             
  Rat  1133 SSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAVPTGPSQEGPQCPVGQGAKVTGPQQT 1197

  Fly   902 DLSKSFVF-VQVGGQKKE----LRP---------------------------------------- 921
            .|..|... ::.||.:::    |||
  Rat  1198 SLGASGTLQLRTGGDREKEEPPLRPHNGGIPHGPREGTSGRQTDSKSRSWAPGHLPVVRRAKSEG 1262

  Fly   922 --VESLATSP-------------------KHRPSISAAAAMS-----VDVTVDRTDGGRGEDSI- 959
              :..|:.:|                   .||.|:|::::||     :|:::......|..:||
  Rat  1263 QVLSELSPTPAVYSDATGSDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIP 1327

  Fly   960 SIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKK 1024
            .:....:..:..|..:....:..|..|:.:.:|.:|..|....|....:    .:..:|..|..:
  Rat  1328 GVSLGRLTPRPCLASAARPDLPPVTKSKSNPNLRVAGGLPLAPDELQPR----PLAPRLTGLHSR 1388

  Fly  1025 HDKEKIKIAGQKSSPLEGKK------------PKFAITNKLVKRLSNKSLNC-LSP----HS--E 1070
            .....:.:.|.:..|:..|.            |.|        :.|..||:| |||    |.  |
  Rat  1389 PPWHHLTLVGLRDCPVSAKSKSLGDLTADDFGPSF--------QGSTGSLSCGLSPLGVVHQVLE 1445

  Fly  1071 PGVEIPACPLDL---------GDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYR 1126
            ||....|....|         ||.:..::...|.:...||.|.|  |...||.:|..|...|:.|
  Rat  1446 PGRRRDALTEQLRWLTGFQHAGDITSPTSLGPAADGSVGGPSFL--RRSSSRSQSRVRAIASRAR 1508

  Fly  1127 ELQEK 1131
            :.||:
  Rat  1509 QAQER 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	26/143 (18%)
		EFh_PI-PLC21	151..305	CDD:320043	32/163 (20%)
		EF-hand motif	151..180	CDD:320043	4/30 (13%)
		EF-hand motif	187..216	CDD:320043	8/36 (22%)
		EF-hand motif	225..255	CDD:320043	4/29 (14%)
		EF-hand motif	272..305	CDD:320043	12/32 (38%)
		PI-PLCc_beta	317..702	CDD:176533	151/446 (34%)
		C2_PLC_like	736..855	CDD:175974	47/148 (32%)
		PTZ00121	<981..>1253	CDD:173412	42/179 (23%)
Plch2	XP_008762618.2	PH_PLC_eta	192..298	CDD:270170	22/129 (17%)
		EFh_PI-PLCeta2	316..456	CDD:320051	33/165 (20%)
		EF-hand motif	316..345	CDD:320051	5/43 (12%)
		EF-hand motif	352..382	CDD:320051	6/29 (21%)
		EF-hand motif	386..414	CDD:320051	4/29 (14%)
		PLN02222	406..1017	CDD:177868	220/662 (33%)
		EF-hand motif	423..456	CDD:320051	12/32 (38%)
		PI-PLCc_eta2	468..877	CDD:176570	151/446 (34%)
		PHA03247	<1052..1377	CDD:223021	39/328 (12%)