Protein Alignment Plc21C and Plch1

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_063137859.1
• Gene: Plch1 / 310463
• RGDID: 1561991
• Length: 1703
• Species: Rattus norvegicus
• Alignment Length: 1518
• Identity: 356/1518 - (23%)
• Similarity: 599/1518 - (39%)
• Gaps: 388/1518 - (25%)

  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
  Rat    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||
  Rat    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:
  Rat   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|
  Rat   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            :::.:...|     ..::|:::|.::.|..|..|.::||..::......:..|...::..|||||
  Rat   257 KMSNVTLDY-----CLDVIKKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
  Rat   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            |||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.||.|.|   .|.|........||.
  Rat   382 KDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKL---DLSSVDTGECRQLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD------------------ 500
            |..|:.||::|.||..:|            :|..|...:::..:|.|
  Rat   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 496

  Fly   501 --------------AKAAQ------------QVGLSASHEDGGVTRSTANGDVATGTGTGSAAGT 539
                          .|.:|            :..|.|:|| |.......|.||       ..:|.
  Rat   497 HQVESFIRKKLDSLLKESQIRDKEDPDSFTVRALLKATHE-GLNAHLKQNLDV-------KESGK 553

  Fly   540 AGHAPPLQQIRQSSKDSTGSSDSDSSS---EDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISA 601
            ..|...|.......|..|..|.|.|.|   |:::|.|  |....|......:.::..:...|:|.
  Rat   554 KSHGRSLMANFGKHKQKTPKSRSKSYSTDDEEDTLQN--PGKEGGQLYRLGRRRRTMKLCRELSD 616

  Fly   602 LVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSS 666
            ||.|...:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||
  Rat   617 LVVYTNSV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSS 678

  Fly   667 NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG 731
            ||.|..:|||||||||||:|:....||:|...|:.|...||:|||:.|.:.  ..:|.:...:..
  Rat   679 NFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKG--TFNPLSGDPLPA 741

  Fly   732 IIAGTVSITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLY 786
            .....:.:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||::
  Rat   742 NPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW 804

  Fly   787 DEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASL 848
             ||...| .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:
  Rat   805 -EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASI 862

  Fly   849 FLCVVVKDYVPDDLSNFAEALANP----IKYQSELEKRDIQ-LSVLTDEAEALGSADED------ 902
            |:.:.:.:.    ...::..:.||    :.:....:.|.:| |..|.::....||::.:
  Rat   863 FVHITINEI----FGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHGSSENNSHYVRK 923

  Fly   903 ------LSKSFVFVQVGGQKK---------------------------------ELRPVESLATS 928
                  :.:........|:||                                 :|||| |:...
  Rat   924 RSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVCEATRDQDGVLRRTTRSLQLRPV-SMPVD 987

  Fly   929 PKHRPSIS---AAAAMSVD-----VTVDRTDGGRGEDSI------------SIVAPSIQHQHSLD 973
            .....::|   :.||.:.|     :..|:.||.:|..:|            |..:.::.|:.:.:
  Rat   988 KNLLGALSLPISEAAKNTDGKENYLAEDKDDGRKGPATIKDPHFSNFNKKLSSSSSALLHKDAKN 1052

  Fly   974 QSVSTSIRQVESSQFDVDLVLAEPLEKILDHKS-------------VKEKRLEMEKKLESLRKKH 1025
            |..:.|:...|...     .|.....:|..|.:             ...|.|.::...:.|:..|
  Rat  1053 QGPTASVSNPEQCG-----GLGLKSGRIKPHMTNDCQENRSPQNFLSPRKHLALDPATKGLQDLH 1112

  Fly  1026 -------DKEKIK-IAGQKSSP--------------LEGKKPKFAITNKLVKRLSNKSLNCLSPH 1068
                   ::|:.| ..|:||:.              |||.|.|.......  .||:.|..|   .
  Rat  1113 GMRTDEKEQERAKGFVGRKSTQSESVLSQSSLEVENLEGSKAKGRAATSF--SLSDVSALC---S 1172

  Fly  1069 SEPGVEIPACPLD--LGDSSEESAAADAGEDLAGGS-SSLDGRTQESRLRSACREYTSQYRELQE 1130
            ..|.:...|...|  :.|...:....:|.|  :|.| |:|.|:.:||.
  Rat  1173 DIPDLHSTAILQDTEISDLINDVTLTNANE--SGSSISALIGQFEESN----------------- 1218

  Fly  1131 KYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRN---EVKNLATVHRDRDELI 1192
              |.|..:...::|.||.|.:...|..:|.         ||...:|   :.|:.|:......||.
  Rat  1219 --HRANVAVVSRLLSTSGTSEGVALPVALG---------LQTPIKNGFSQGKHKASFLCSSPELN 1272

  Fly  1193 RMK----REVASSVVERGV--------------AERVRLKQTFDRRTDELQKQHDSVRNALAE-- 1237
            :..    .::|::.|..||              :::.:.:.|    .|.|....|:......:
  Rat  1273 KPSSAETTKLANNTVACGVIGSPISTPKPGDDASDKAKTRVT----EDNLPDSPDAFPGQFPQSP 1333

  Fly  1238 -HRSKARQIL------------DKEAESRSCVSSNGFLVLFHGPHHHGCTGSGSSALSGNNLTLN 1289
             |....||::            |..|:...|::|.               .|....:.|::.:|:
  Rat  1334 THGEDHRQVMSSPALSMPLAMEDTTADPALCINSE---------------ESSLVEIDGDSESLS 1383

  Fly  1290 L---DAGAAGSHSAISPAKSHNS 1309
            |   |.|.......:||.|...|
  Rat  1384 LTACDYGEEALSQLVSPLKLQQS 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/145 (19%)
		EFh_PI-PLC21	151..305	CDD:320043	26/153 (17%)
		EF-hand motif	151..180	CDD:320043	4/28 (14%)
		EF-hand motif	187..216	CDD:320043	3/28 (11%)
		EF-hand motif	225..255	CDD:320043	6/29 (21%)
		EF-hand motif	272..305	CDD:320043	7/32 (22%)
		PI-PLCc_beta	317..702	CDD:176533	146/431 (34%)
		C2_PLC_like	736..855	CDD:175974	43/131 (33%)
		PTZ00121	<981..>1253	CDD:173412	63/345 (18%)
Plch1	XP_063137859.1	None