Protein Alignment Plc21C and Plcl2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_001100350.2
• Gene: Plcl2 / 301173
• RGDID: 1305941
• Length: 1128
• Species: Rattus norvegicus
• Alignment Length: 1131
• Identity: 299/1131 - (26%)
• Similarity: 490/1131 - (43%)
• Gaps: 291/1131 - (25%)

  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.:|::||||:.....:.|.:.:.::       |:...:|.:
  Rat   166 LDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQIS-------EDCAFSVIY 223

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGLIKL----AYSLAQLNGSAIMFLQKAHTKLC-------- 158
            |.::.::..|   ....|:|.:|..||..|    .::|..|..|      :.:.:.|
  Rat   224 GENYESLDLV---ANSADVANIWVTGLRYLISYGKHTLDMLESS------QDNMRTCWVSQMFSE 279

  Fly   159 LQVDKSGRIPVKNIIKLF---------AQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFY 214
            :.||..|.|.:.|.::..         ::.:...|.:.|:.|.||....|           |:|.
  Rat   280 IDVDDLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKTGTEITK-----------EEFV 333

  Fly   215 NLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQ 279
            .::..|..|.|:  .|..:..:|.::.:....|:.||...|....:||.:        :.|:|.:
  Rat   334 EVFHELCTRPEI--YFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHK 388

  Fly   280 YEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTG 344
            |||:|...:||.||:|||..|||..|..|..|....:|.||.||:|||||||||||||...|..|
  Rat   389 YEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRG 453

  Fly   345 KSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVIL 409
            .|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|::.|.:.||..||||:||
  Rat   454 PSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLIL 518

  Fly   410 SFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKNKKKHHH 471
            ..||||:.:||..:..:.::|.||.|       :...|||:   ||.|.:|:.||:||.||
  Rat   519 CLENHCSIKQQKVMVQHMKKILGDKL-------YTTSPNMEESYLPSPDVLKGKILIKAKK---- 572

  Fly   472 HHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSA 536
                                               :..:.|..:|.||......:::...|
  Rat   573 -----------------------------------LSSNCSGVEGDVTDEDEGAEMSQRMG---- 598

  Fly   537 AGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISA 601
                                         .|:...||..|             .|..:...::|.
  Rat   599 -----------------------------KENVEQPNHVP-------------VKRFQLCKDLSE 621

  Fly   602 LVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSS 666
            ||:..:.:.|..|:.:.:..:.:|:.||:|..|:....|.|.:||||||..|:||:|:..|.|||
  Rat   622 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSS 686

  Fly   667 NFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDG 731
            |..||.||..|||:||:||||..|.|.||:|.|..|...||:|:|..||..........:.:|.|
  Rat   687 NMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPG 751

  Fly   732 IIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDE 788
            :....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||..|::||
  Rat   752 VSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVNQNGDAPMFDE 814

  Fly   789 EPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            . |.| ::.|||||.:|....::   |.:.||...:|...|..|||||.|:|..|:.:|.||||:
  Rat   815 S-FEF-QINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 877

  Fly   851 CVVV----------------------KDYVP---------DDLSNFAEALANPIKYQSELEKRDI 884
            .|.:                      ::|..         |::...|:.   ||:..::| :.::
  Rat   878 HVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQP---PIRDATDL-RENM 938

  Fly   885 QLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVES--------LATSPKHRPSISAAAAM 941
            |.:|:                ||         |||..:.|        ||.||:.
  Rat   939 QNAVV----------------SF---------KELCGLSSVANLMQCMLAVSPRF---------- 968

  Fly   942 SVDVTVDRTDGGRGEDSISIVAPSIQHQH---SLDQSVSTSIRQVESSQFDVDLVLAEPLEKILD 1003
                        .|.|:..:|..::...:   .|...|...::::.:: :|   ::.:.|:.:::
  Rat   969 ------------LGPDNTPLVVLNLSEPYPTMELQAIVPEVLKKIVTT-YD---MMIQSLKALIE 1017

  Fly  1004 H-KSVKEK-------RLEMEKKLESLRKKHDKEKIKIAGQKS--------SPLEGKKP--KFAIT 1050
            : .:|.||       .:|..:.|.|:..|...::.|:  ||:        :.|:|:..  |:|..
  Rat  1018 NADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKL--QKAVESFTWNITILKGQADLLKYAKN 1080

  Fly  1051 NKL--VKRLSNKSLNCLSPHSEPGVE 1074
            ..|  :|::...:::|  ..::||.|
  Rat  1081 ETLENLKQIHYAAVSC--GLNKPGTE 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	25/107 (23%)
		EFh_PI-PLC21	151..305	CDD:320043	41/170 (24%)
		EF-hand motif	151..180	CDD:320043	6/45 (13%)
		EF-hand motif	187..216	CDD:320043	7/28 (25%)
		EF-hand motif	225..255	CDD:320043	6/29 (21%)
		EF-hand motif	272..305	CDD:320043	16/32 (50%)
		PI-PLCc_beta	317..702	CDD:176533	128/387 (33%)
		C2_PLC_like	736..855	CDD:175974	47/151 (31%)
		PTZ00121	<981..>1253	CDD:173412	22/114 (19%)
Plcl2	NP_001100350.2	None