Protein Alignment Plc21C and Plcd3

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_001099315.3
• Gene: Plcd3 / 287745
• RGDID: 1310903
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 754
• Identity: 231/754 - (30%)
• Similarity: 348/754 - (46%)
• Gaps: 147/754 - (19%)

  Fly   125 AQLWTDGLIKLAYSL------AQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDR 183
            ||.|..||.||...|      .:|:.....:|.:|.:      |:..::..|.|..|......|.
  Rat   156 AQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADS------DQDSKMSFKEIKSLLRMVNVDM 214

  Fly   184 K-----RVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMS 243
            .     |:.|..|.:.  :.:::...:..|        .:.|.:|.|:|.:|....|..  :.:|
  Rat   215 NDMYAYRLFKECDHSN--NERLEGAEIEAF--------LRRLLKRPELEEIFRRYSGED--RVLS 267

  Fly   244 IAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPI 308
            .::|:|||.....|.         |..|.|::|||.||.|:...|...::||||:.||:..:...
  Rat   268 ASELLEFLEDQGEDG---------ATLACAQKLIQTYELNETAKQHELMTLDGFMMYLLSPEGAA 323

  Fly   309 MAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEE 373
            :..:...:..||.||::||||:||||||||..|:.|.||.|.|.:....||||||||.|.|...|
  Rat   324 LNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFTQGCRCVELDCWEGPGGE 388

  Fly   374 PVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDK 438
            |||.||:|...:|..:||::|:.:.||..|.||||||.||||...||..:|.:.|.|.||||:.:
  Rat   389 PVIYHGHTLTSKILFRDVIQAVRDHAFTLSPYPVILSLENHCGLEQQIVMARHLRNILGDMLVTQ 453

  Fly   439 PLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKA 503
            .|||...|   :||.|..|:.::::|.||                  .|||.|
  Rat   454 ALDSQNPE---ELPSPEQLKCRVLVKGKK------------------LPAARN------------ 485

  Fly   504 AQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSED 568
                      |||                               :|....:|    .|.|....:
  Rat   486 ----------EDG-------------------------------RILSDRED----EDEDEEEAE 505

  Fly   569 ESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQ 633
            |:|...            |:.::..:...|:||||.|.......:.|.:....:..::.|..|::
  Rat   506 EALETA------------EQRKRAKQISPELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERK 558

  Fly   634 ATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGI 698
            |....:|....||.:|..||:||||.|.|..|:|:.||..||:|||||||||||....|.||.|.
  Rat   559 ARKFTREAGTSFVRHNTQQLTRVYPLGLRMTSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGR 623

  Fly   699 FEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTD---KRANTFVE--- 757
            |..|.:.||:|||.::|:.:...||    ...|....|:::.||:.|.|..   ::.|:.|:
  Rat   624 FLINGQCGYVLKPAYLRQLNTTFDP----ECPGPPRTTLTVQVLTAQQLPKLNVEKPNSIVDPLV 684

  Fly   758 -VDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE----EGGKLIG 817
             |::||:|.|...|:  |..|.:||.||.: |:...| ::..|||..:|....:    .....:|
  Rat   685 RVEIYGVPEDCAHKE--TDYVLNNGFNPCW-EQTLQF-QLRAPELVLVRFVVEDYDTTSPNDFVG 745

  Fly   818 HRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKD 856
            ...||:..|..||||::|.|:.|..::.|:||:.:.:::
  Rat   746 QFTLPLNSLKQGYRHIHLLSKDGASLSPATLFVHIRIEN 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	9/25 (36%)
		EFh_PI-PLC21	151..305	CDD:320043	38/158 (24%)
		EF-hand motif	151..180	CDD:320043	5/28 (18%)
		EF-hand motif	187..216	CDD:320043	3/28 (11%)
		EF-hand motif	225..255	CDD:320043	9/29 (31%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	134/384 (35%)
		C2_PLC_like	736..855	CDD:175974	39/129 (30%)
		PTZ00121	<981..>1253	CDD:173412
Plcd3	NP_001099315.3	PH_PLC_delta	61..177	CDD:270169	8/20 (40%)
		EF-hand_10	197..246	CDD:405477	8/58 (14%)
		PLN02228	251..783	CDD:177873	209/640 (33%)
		PI-PLCc_delta3	332..627	CDD:176567	134/384 (35%)