Protein Alignment Plc21C and Plch2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_011248570.1
• Gene: Plch2 / 269615
• MGIID: 2443078
• Length: 1759
• Species: Mus musculus
• Alignment Length: 1394
• Identity: 342/1394 - (24%)
• Similarity: 541/1394 - (38%)
• Gaps: 394/1394 - (28%)

  Fly    19 ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVR 71
            |:|:|.:.::            :|..:||.. .|::|::           ||...:.|.:|::|.
Mouse   192 AMQEGTQMVK------------LRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVS 244

  Fly    72 TGQYAKRPKDNKLRQIVTLGPQDTLEEK-TVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL--- 132
            .|:.:         :|....|..:.:.. ..::.|||...::..|:   ...:.|:.|..||
Mouse   245 EGRQS---------EIFQRYPDSSFDPNCCFSIYHGSHRESLDLVS---PSSEEARTWVTGLRYL 297

  Fly   133 ---IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKS--GRIPVKNIIKLFAQNKEDRKRVEKALDV 192
               |....|||:...:...:|::...    :.||:  |.:.:..:::|..:           |:|
Mouse   298 MAGISDEDSLARRQRTRDQWLKQTFD----EADKNGDGSLSISEVLQLLHK-----------LNV 347

  Fly   193 TGLPSGKVDSI--------SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVE 249
             .||..:|..:        ......||:|...||.::.|.::..|.  :..::.:..:..:.|..
Mouse   348 -NLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM--LTYSNHKDHLDASDLQR 409

  Fly   250 FLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLD------------------- 295
            ||...|   ::|.:..     ...:.:|:|:||...|..||.|.:|
Mouse   410 FLEVEQ---KMNGVTL-----ESCQNIIEQFEPCLENKSKGMLGIDGSREPSPVMEIHHGAPVYT 466

  Fly   296 -GFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGC 359
             ||..|.......|..|....:..||.||:|||||.|||||||.|.||..:|.|::|...|.|||
Mouse   467 AGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGC 531

  Fly   360 RCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIA 424
            ||||:|.|:|...||::.||||...:|..|||:|.|.:.||..:|||||||.||||:..||.|:|
Mouse   532 RCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMA 596

  Fly   425 NYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAA 489
            .|..:|.||.|   .|.|...|....||.|.||:.||::|.|            |.||.:...|.
Mouse   597 QYLTDILGDKL---DLSSVSSEDATMLPSPQMLKGKILVKGK------------KLPANISEDAE 646

  Fly   490 NNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSK 554
            ..:::..:|.|           ..||   .....|||.:|..               :::...:|
Mouse   647 EGEVSDEDSAD-----------EMED---DCKLLNGDASTNR---------------KRVENIAK 682

  Fly   555 DSTGSSDSDSSSEDESLPN---TTPNLPSGN-------EPPPEKAQKETEAGAEISALVNYVQPI 609
            ....|...:|...|...||   .:...|||.       :....|.:::.||| |.|.:......:
Mouse   683 KKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAG-EDSGVSRQNSRL 746

  Fly   610 HFSSFENAEKKN----------------------------------------------------- 621
            ..|||...:||.
Mouse   747 FMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHD 811

  Fly   622 ------RCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQL 680
                  ..:::|||.|.:|..:|:::|.:::.:|:|||||:||:..|.||||:.||.|||||||:
Mouse   812 VEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQM 876

  Fly   681 VALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQ 745
            ||||:|:....:|||...|..|...||:|||:.|.:.  ..:|.:|..:.|.:...:::.::|||
Mouse   877 VALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQG--VFNPNSEDPLPGQLKKQLALRIISGQ 939

  Fly   746 FLTDKR----------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPE 800
            .|...|          .:.||||::.|||.|.  .|.:|:.|.|||.||:: ||..|| .|.:||
Mouse   940 QLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDC--SKEQTRVVDDNGFNPMW-EETLVF-TVHMPE 1000

  Fly   801 LASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHV-----------------NLRSEVGQPIAL 845
            :|.:|...::.   |...||.|.|....:.||||||                 ::..:|.|.:.|
Mouse  1001 IALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGL 1065

  Fly   846 ASLFLCVVVKDYVPDDLSNFA----------------EALANPIKYQSELEKRDIQLSVLTDEAE 894
            ..|||    :...|..|.:.|                ...:.|.|.|....|...:|::.|.:|.
Mouse  1066 KGLFL----RGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAG 1126

  Fly   895 ALGSADEDLSKSFVFVQV------------------GGQKKELR---------------PVESLA 926
            :.|:|| |::.|.....:                  ||:..|.|               |....|
Mouse  1127 SEGAAD-DVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAA 1190

  Fly   927 TSPK-----------------HRPSISAAAA-MSVD----VTVDRTDG-----------GRGEDS 958
            |..|                 .:||...|.: |::.    ..||...|           ||.:::
Mouse  1191 TCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEA 1255

  Fly   959 ISIVAPSIQHQHSLDQSVST--------------------SIRQVESSQFDVDLVLAEPLEKILD 1003
            ..  .|..:.|.....|||:                    :.||..:.|.:::.:..:.||:|..
Mouse  1256 PK--GPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRS 1318

  Fly  1004 HK---SVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCL 1065
            |.   |...:...:::.:..|.......:....| ...||:...|
Mouse  1319 HSPMFSTDTRLFPLQRPISPLCSLEPIAEEPALG-PGLPLQAAAP-------------------- 1362

  Fly  1066 SPHSEPGVEIPACPLDLG---DSSEESAAADAGE---DLAGGSSSLDG--RTQESRLRSACREYT 1122
               :.|..|...||:.||   .||::::....|.   .:.||..:.:.  |.....:.|..||.|
Mouse  1363 ---TGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGT 1424

  Fly  1123 SQYRELQEKYHEAIYSAAEKVLKTSQTGQ 1151
            |. |:...|....:......|.:....||
Mouse  1425 SG-RQTDSKSRSRVPGHLPVVRRAKSEGQ 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/143 (19%)
		EFh_PI-PLC21	151..305	CDD:320043	33/183 (18%)
		EF-hand motif	151..180	CDD:320043	4/30 (13%)
		EF-hand motif	187..216	CDD:320043	8/36 (22%)
		EF-hand motif	225..255	CDD:320043	4/29 (14%)
		EF-hand motif	272..305	CDD:320043	12/52 (23%)
		PI-PLCc_beta	317..702	CDD:176533	149/453 (33%)
		C2_PLC_like	736..855	CDD:175974	47/148 (32%)
		PTZ00121	<981..>1253	CDD:173412	35/182 (19%)
Plch2	XP_011248570.1	PH_PLC_eta	193..299	CDD:270170	23/129 (18%)
		EFh_PI-PLC	317..477	CDD:333715	34/185 (18%)
		EF-hand motif	317..346	CDD:320029	5/43 (12%)
		EF-hand motif	353..382	CDD:320029	6/28 (21%)
		EF-hand motif	387..415	CDD:320029	4/29 (14%)
		EF-hand motif	424..477	CDD:320029	12/52 (23%)
		PLN02228	459..1038	CDD:177873	205/629 (33%)
		PI-PLCc_eta2	489..898	CDD:176570	149/453 (33%)
		PHA03247	<1087..1579	CDD:223021	69/394 (18%)